{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:17:27Z","timestamp":1792142247767,"version":"4.4.0"},"reference-count":23,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interventions that improve cognitive function in Alzheimer's disease are urgently required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess whether a novel cognitive training paradigm based on \u2018chunking\u2019 improves working memory and general cognitive function, and is associated with reorganisation of functional activity in prefrontal and parietal cortices (trial registration: ISRCTN43007027).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Thirty patients with mild Alzheimer's disease were randomly allocated to receive 18 sessions of 30 min of either adaptive chunking training or an active control intervention over approximately 8 weeks. Pre- and post-intervention functional magnetic resonance imaging (fMRI) scans were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adaptive chunking training led to significant improvements in verbal working memory and untrained clinical measures of general cognitive function. Further, fMRI revealed a bilateral reduction in task-related lateral prefrontal and parietal cortex activation in the training group compared with controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chunking-based cognitive training is a simple and potentially scalable intervention to improve cognitive function in early Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.bp.116.182048","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T20:38:15Z","timestamp":1475786295000},"page":"61-66","source":"Crossref","is-referenced-by-count":54,"title":["Adaptive working memory strategy training in early Alzheimer's disease: Randomised controlled trial"],"prefix":"10.1192","volume":"210","author":[{"given":"J. D.","family":"Huntley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hampshire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000280707_ref3","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.083857"},{"key":"S0007125000280707_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi005"},{"key":"S0007125000280707_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.05.002"},{"key":"S0007125000280707_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03438.x"},{"key":"S0007125000280707_ref21","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.4.745"},{"key":"S0007125000280707_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005247"},{"key":"S0007125000280707_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr037"},{"key":"S0007125000280707_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2314"},{"key":"S0007125000280707_ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155466"},{"key":"S0007125000280707_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nn1165"},{"key":"S0007125000280707_ref23","volume-title":"Policy Brief for Heads of Government: The Global Impact of Dementia 2013\u20132050.","author":"Prince","year":"2013"},{"key":"S0007125000280707_ref19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.853"},{"key":"S0007125000280707_ref2","doi-asserted-by":"publisher","DOI":"10.1037\/h0043158"},{"key":"S0007125000280707_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.01.003"},{"key":"S0007125000280707_ref13","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00432"},{"key":"S0007125000280707_ref4","first-page":"CD003260","article-title":"Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia","volume":"4","author":"Clare","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"S0007125000280707_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2271"},{"key":"S0007125000280707_ref8","first-page":"CD003260","article-title":"Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer's disease and vascular dementia","volume":"6","author":"Bahar-Fuchs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"S0007125000280707_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198524410.003.0007"},{"key":"S0007125000280707_ref11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.167"},{"key":"S0007125000280707_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20131"},{"key":"S0007125000280707_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01171-6"},{"key":"S0007125000280707_ref17","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000280707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T01:23:30Z","timestamp":1555550610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000280707\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0007125000280707"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.116.182048","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726865902.793535028","asserted-by":"object"}]},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}