{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:15:17Z","timestamp":1792430117840,"version":"4.5.0"},"reference-count":42,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":215,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Maintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg\/day) and followed up for 1 year. (Trial registration: Australian and New Zealand Clinical Trials Registry \u2013 ACTRN12607000639426.)<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 61 individuals were randomised. Within mixed-model repeated measures analyses, significant omnibus treatment \u00d7 visit interactions were observed for measures of overall psychopathology, psychotic symptoms and functioning. Planned and<jats:italic>post hoc<\/jats:italic>comparisons further demonstrated the superiority of lithium treatment over quetiapine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In people with first-episode mania treated with a combination of lithium and quetiapine, continuation treatment with lithium rather than quetiapine is superior in terms of mean levels of symptoms during a 1-year evolution.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.116.186833","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T01:10:14Z","timestamp":1488503414000},"page":"413-421","source":"Crossref","is-referenced-by-count":64,"title":["Quetiapine<i>v.<\/i>lithium in the maintenance phase following a first episode of mania: Randomised controlled trial"],"prefix":"10.1192","volume":"210","author":[{"given":"Michael","family":"Berk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rothanthi","family":"Daglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orwa","family":"Dandash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Y\u00fccel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hallam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Macneil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Hasty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Pantelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Kader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saji","family":"Damodaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T. H.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Conus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswin","family":"Ratheesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"McGorry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue M.","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000281671_ref41","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000224"},{"key":"S0007125000281671_ref31","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199001000-00010"},{"key":"S0007125000281671_ref20","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"S0007125000281671_ref17","article-title":"Atypical antipsychotic augmentation of mood stabilizer therapy in bipolar disorder","volume":"66","author":"Bowden","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"S0007125000281671_ref30","article-title":"Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry","volume":"61","author":"Gueorgieva","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"S0007125000281671_ref10","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0116"},{"key":"S0007125000281671_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00123-6"},{"key":"S0007125000281671_ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.149.2.191"},{"key":"S0007125000281671_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.09.009"},{"key":"S0007125000281671_ref13","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1351"},{"key":"S0007125000281671_ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.142802"},{"key":"S0007125000281671_ref14","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04995gre"},{"key":"S0007125000281671_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00909-4"},{"key":"S0007125000281671_ref16","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.7.1263"},{"key":"S0007125000281671_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.09.022"},{"key":"S0007125000281671_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/pst.124"},{"key":"S0007125000281671_ref23","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"S0007125000281671_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.02.028"},{"key":"S0007125000281671_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12099"},{"key":"S0007125000281671_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00359-2"},{"key":"S0007125000281671_ref7","article-title":"Nonresponse to reinstituted lithium prophylaxis in previously responsive bipolar patients: prevalence and predictors","volume":"152","author":"Maj","year":"1995","journal-title":"Am J Psychiatry"},{"key":"S0007125000281671_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00385.x"},{"key":"S0007125000281671_ref9","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.12.10.1621"},{"key":"S0007125000281671_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.02.006"},{"key":"S0007125000281671_ref19","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I\/P)","author":"First","year":"2002"},{"key":"S0007125000281671_ref21","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"S0007125000281671_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00536.x"},{"key":"S0007125000281671_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/10.3.388"},{"key":"S0007125000281671_ref28","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.220"},{"key":"S0007125000281671_ref12","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X46340"},{"key":"S0007125000281671_ref33","doi-asserted-by":"publisher","DOI":"10.1177\/1740774513512184"},{"key":"S0007125000281671_ref34","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m06878"},{"key":"S0007125000281671_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.192"},{"key":"S0007125000281671_ref35","doi-asserted-by":"publisher","DOI":"10.1002\/da.22136"},{"key":"S0007125000281671_ref36","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0206"},{"key":"S0007125000281671_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.001"},{"key":"S0007125000281671_ref38","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12581"},{"key":"S0007125000281671_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00241-X"},{"key":"S0007125000281671_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s004060050091"},{"key":"S0007125000281671_ref25","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.166.5.654"},{"key":"S0007125000281671_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.05.014"},{"key":"S0007125000281671_ref26","doi-asserted-by":"crossref","DOI":"10.1034\/j.1600-0447.2000.101004323.x","article-title":"Development, reliability and acceptability of a new version of the DSM-IV Social Occupational Functioning Assessment Scale (SOFAS) to assess routine social functioning","volume":"101","author":"Morosini","year":"2000","journal-title":"Acta Psychiatr Scand"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000281671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T09:17:39Z","timestamp":1601716659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000281671\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0007125000281671"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.116.186833","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}