{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:47:12Z","timestamp":1792842432516,"version":"4.5.0"},"reference-count":43,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":123,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood trauma has been significantly associated with first-episode psychosis, affective dysfunction and substance use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d.=9.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe sexual abuse was significantly associated with a diagnosis of affective psychosis (\u03c7<jats:sup>2<\/jats:sup>=4.9,<jats:italic>P<\/jats:italic>=0.04) and with higher rates of lifetime use of cannabis (68%<jats:italic>v.<\/jats:italic>41%;<jats:italic>P<\/jats:italic>= 0.02) and heroin (20%<jats:italic>v.<\/jats:italic>5%;<jats:italic>P<\/jats:italic>=0.02). Severe physical abuse was associated with increased lifetime use of heroin (15%<jats:italic>v.<\/jats:italic>5%;<jats:italic>P<\/jats:italic>= 0.03) and cocaine (32%<jats:italic>v.<\/jats:italic>17%;<jats:italic>P<\/jats:italic>= 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.116.194019","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:11:14Z","timestamp":1500595874000},"page":"151-156","source":"Crossref","is-referenced-by-count":36,"title":["Influence of childhood trauma on diagnosis and substance use in first-episode psychosis"],"prefix":"10.1192","volume":"211","author":[{"given":"S.","family":"Tomassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tosato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mondelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Faravelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lasalvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fioravanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bonetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fioritti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cremonese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Lo","family":"Parrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"De Santi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Meneghelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Torresani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"De Girolamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Semrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pratelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cristofalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the GET UP Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000280185_ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.152611"},{"key":"S0007125000280185_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.05.023"},{"key":"S0007125000280185_ref3","article-title":"Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis","volume":"169","author":"Nanni","year":"2011","journal-title":"Am J Psychiatry"},{"key":"S0007125000280185_ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-015-1048-8"},{"key":"S0007125000280185_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710000231"},{"key":"S0007125000280185_ref41","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp103"},{"key":"S0007125000280185_ref17","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.70.1.246"},{"key":"S0007125000280185_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2014.10.005"},{"key":"S0007125000280185_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810180089012"},{"key":"S0007125000280185_ref23","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.6.543"},{"key":"S0007125000280185_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv058"},{"key":"S0007125000280185_ref9","article-title":"Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk","volume":"42","author":"Konings","year":"2011","journal-title":"Psychol Med"},{"key":"S0007125000280185_ref37","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.64.4.319.18602"},{"key":"S0007125000280185_ref19","volume-title":"Maltrattamento sui bambini: quante le vittime in Italia? Prima Indagine nazionale quali\u2013quantitativa sul maltrattamento a danno di bambini.","author":"Bollini","year":"2013"},{"key":"S0007125000280185_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.01011.x"},{"key":"S0007125000280185_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170700013X"},{"key":"S0007125000280185_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711001991"},{"key":"S0007125000280185_ref32","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1652"},{"key":"S0007125000280185_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(77)90206-0"},{"key":"S0007125000280185_ref5","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0447.2009.01477.x","article-title":"The relationship between childhood trauma history and the psychotic subtype of major depression","volume":"121","author":"Gaudiano","year":"2010","journal-title":"Acta Psychiatr Scand"},{"key":"S0007125000280185_ref4","article-title":"The impact of childhood adversity on suicidality and clinical course in treatment-resistant depression","volume":"152\u20134","author":"Tunnard","year":"2014","journal-title":"J Affect Disord"},{"key":"S0007125000280185_ref34","article-title":"Does the concept of \u2018sensitization\u2019 provide a plausible mechanism for the putative link between the environment and schizophrenia?","volume":"34","author":"Collip","year":"2008","journal-title":"Schizophr Bull"},{"key":"S0007125000280185_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2010.10.011"},{"key":"S0007125000280185_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000559"},{"key":"S0007125000280185_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-73"},{"key":"S0007125000280185_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0264180100000904"},{"key":"S0007125000280185_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2006.09.005"},{"key":"S0007125000280185_ref14","doi-asserted-by":"publisher","DOI":"10.1348\/014466505X35344"},{"key":"S0007125000280185_ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000092678"},{"key":"S0007125000280185_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.01.035"},{"key":"S0007125000280185_ref40","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.047985"},{"key":"S0007125000280185_ref18","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511544064.007"},{"key":"S0007125000280185_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.00218.x"},{"key":"S0007125000280185_ref20","volume-title":"Global Status Report on Violence Prevention.","year":"2014"},{"key":"S0007125000280185_ref28","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0611"},{"key":"S0007125000280185_ref22","doi-asserted-by":"publisher","DOI":"10.3402\/ejpt.v6.28847"},{"key":"S0007125000280185_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2013.03.013"},{"key":"S0007125000280185_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.08.013"},{"key":"S0007125000280185_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00998-7"},{"key":"S0007125000280185_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.11.009"},{"key":"S0007125000280185_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2009.07.004"},{"key":"S0007125000280185_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.07.006"},{"key":"S0007125000280185_ref39","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415575379"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000280185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T17:44:58Z","timestamp":1719337498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000280185\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0007125000280185"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.116.194019","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}