{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:54:56Z","timestamp":1783738496350,"version":"3.55.0"},"reference-count":25,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":427,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJPsych open"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Substantial evidence indicates that perinatal mental disturbances are associated with the risk for negative maternal-newborn outcomes. A neuroendocrine brain-placenta interaction has been described to explain the association between prenatal stress-related disorders and placental abnormalities. Whether these mechanisms may affect the likelihood of mother-to-child transmission (MTCT) of infections has never been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the role of psychological factors in cytomegalovirus (CMV) MTCT in pregnant women with primary CMV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A cohort of 276 pregnant women with primary CMV infection underwent assessment of (a) reactive psychopathological symptoms, such as current depressive symptoms and ongoing symptoms of post-traumatic stress disorder; and (b) stable personality traits, such as alexithymia and Type D (distressed) personality. Congenital infection was diagnosed by CMV DNA amplification from blood and\/or urine and saliva from newborn at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The occurrence of congenital CMV disease in the newborn was independently predicted by post-traumatic stress symptoms during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that psychological stress-related disturbances may weaken the physical and immunological barrier against the mother-to-fetus transmission of viruses.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjpo.bp.116.003152","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T17:46:48Z","timestamp":1481737608000},"page":"373-376","source":"Crossref","is-referenced-by-count":6,"title":["Post-traumatic stress in pregnant women with primary cytomegalovirus infection and risk of congenital infection in newborns"],"prefix":"10.1192","volume":"2","author":[{"given":"Francesco","family":"Vadini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Tracanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ennio","family":"Polilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Tontodonati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Santilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giustino","family":"Parruti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S2056472400001885_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit584"},{"key":"S2056472400001885_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir718"},{"key":"S2056472400001885_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.4374"},{"key":"S2056472400001885_ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052899"},{"key":"S2056472400001885_ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083916"},{"key":"S2056472400001885_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.07.015"},{"key":"S2056472400001885_ref14","first-page":"7","article-title":"Type D Personality, a relevant construct in cardiology. 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