{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:37:19Z","timestamp":1791549439149,"version":"4.3.4"},"reference-count":45,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"unspecified","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933819000166_sec18\" sec-type=\"other\">\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Borderline personality disorder (BPD) presents with symptoms across different domains, whose neurobiology is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933819000166_sec13\" sec-type=\"methods\">\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>We applied voxel-based morphometry on high-resolution magnetic resonance imaging scans of 19 female BPD patients and 50 matched female controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933819000166_sec14\" sec-type=\"results\">\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Group comparison showed bilateral orbitofrontal gray matter loss in patients, but no significant changes in the hippocampus. Voxel-wise correlation of gray matter with symptom severity scores from the Borderline Symptom List (BSL-95) showed overall negative correlation in bilateral prefrontal, right inferior temporal\/fusiform and occipital cortices, and left thalamus. Significant (negative) correlations with BSL-95 subscores within the patient cohort linked autoaggression to left lateral prefrontal and insular cortices, right inferior temporal\/temporal pole, and right orbital cortex; dysthymia\/dysphoria to right orbitofrontal cortex; self-perception to left postcentral, bilateral inferior\/middle temporal, right orbitofrontal, and occipital cortices. Schema therapy-based Young Schema Questionnaire (YSQ-S2) scores of early maladaptive schemas on emotional deprivation were linked to left medial temporal lobe gray matter reductions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933819000166_sec15\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Our results confirm orbitofrontal structural deficits in BPD, while providing a framework and preliminary findings on identifying structural correlates of symptom dimensions in BPD, especially with dorsolateral and orbitofrontal cortices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2019.16","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T09:45:50Z","timestamp":1581068750000},"source":"Crossref","is-referenced-by-count":22,"title":["Brain structure and symptom dimensions in borderline personality disorder"],"prefix":"10.1192","volume":"63","author":[{"given":"Igor","family":"Nenadi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Besteher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Langbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-099X","authenticated-orcid":false,"given":"Christian","family":"Gaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"S0924933819000166_r44","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2010.07.005"},{"key":"S0924933819000166_r39","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-012-0303-1"},{"key":"S0924933819000166_r38","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714000324"},{"key":"S0924933819000166_r41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.07.025"},{"key":"S0924933819000166_r36","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0757-y"},{"key":"S0924933819000166_r34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"S0924933819000166_r31","doi-asserted-by":"publisher","DOI":"10.1159\/000241195"},{"key":"S0924933819000166_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2016.04.005"},{"key":"S0924933819000166_r25","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04754blu"},{"key":"S0924933819000166_r37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.11.019"},{"key":"S0924933819000166_r32","volume-title":"Diagnostik im Rahmen der Schematherapie unter besonderer Ber\u00fccksichtigung der Pers\u00f6nlichkeitsakzentuierungen. 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