{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:02:59Z","timestamp":1790265779361,"version":"4.1.0"},"reference-count":0,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"unspecified","delay-in-days":117,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S092493382000036X_sec1\" sec-type=\"other\">\n\t    <jats:title>Background.<\/jats:title>\n\t    <jats:p>Earlier studies examining structural brain abnormalities associated with cognitively derived subgroups were mainly cross-sectional in design and had mixed findings. Thus, we obtained cross-sectional and longitudinal data to characterize the extent and trajectory of brain structure abnormalities underlying distinct cognitive subtypes (\u201cpreserved,\u201d \u201cdeteriorated,\u201d and \u201ccompromised\u201d) seen in psychotic spectrum disorders.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S092493382000036X_sec2\" sec-type=\"other\">\n\t    <jats:title>Methods.<\/jats:title>\n\t    <jats:p>Data from 364 subjects (225 patients with psychotic conditions and 139 healthy controls) were first used to determine the relationship of cognitive subtypes with cross-sectional measures of subcortical volume and cortical thickness. To probe neurodevelopmental abnormalities, brain structure laterality was examined. To examine whether neuroprogressive abnormalities persist, longitudinal brain structural changes over 5 years were examined within a subset of 101 subjects. Subsequent discriminant analysis using the identified brain measures was performed on an independent subject group.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S092493382000036X_sec3\" sec-type=\"results\">\n\t    <jats:title>Results.<\/jats:title>\n\t    <jats:p>Cross-sectional comparisons showed that cortical thinning and limbic volume reductions were most widespread in \u201cdeteriorated\u201d cognitive subtype. Laterality comparisons showed more rightward amygdala lateralization in \u201ccompromised\u201d than \u201cpreserved\u201d subtype. Longitudinal comparisons revealed progressive hippocampal shrinkage in \u201cdeteriorated\u201d compared with healthy controls and \u201cpreserved\u201d subtype, which correlated with worse negative symptoms, cognitive and psychosocial functioning. Post-hoc discrimination analysis on an independent group of 52 subjects using the identified brain structures found an overall accuracy of 71% for classification of cognitive subtypes.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S092493382000036X_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusion.<\/jats:title>\n\t    <jats:p>These findings point toward distinct extent and trajectory of corticolimbic abnormalities associated with cognitive subtypes in psychosis, which can allow further understanding of the biological course of cognitive functioning over illness course and with treatment.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2020.36","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T08:22:27Z","timestamp":1587975747000},"source":"Crossref","is-referenced-by-count":5,"title":["Corticolimbic brain anomalies are associated with cognitive subtypes in psychosis: A longitudinal study"],"prefix":"10.1192","volume":"63","author":[{"given":"New Fei","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-4119","authenticated-orcid":false,"given":"Benjamin J. H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordon X. J.","family":"Tng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max Z. Y.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S. E.","family":"Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-9626","authenticated-orcid":false,"given":"Kang","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2020,4,27]]},"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S092493382000036X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T10:31:35Z","timestamp":1589797895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S092493382000036X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020]]}},"alternative-id":["S092493382000036X"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2020.36","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e40"}}