{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:39:16Z","timestamp":1791599956378,"version":"4.3.4"},"reference-count":74,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"unspecified","delay-in-days":306,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S092493382102246X_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To determine the proportion of patients in symptomatic remission and recovery following a first-episode of psychosis (FEP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493382102246X_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multistep literature search using the Web of Science database, Cochrane Central Register of Reviews, Ovid\/PsychINFO, and trial registries from database inception to November 5, 2020, was performed. Cohort studies and randomized control trials (RCT) investigating the proportion of remission and recovery following a FEP were included. Two independent researchers searched, following PRISMA and MOOSE guidelines and using a PROSPERO protocol. We performed meta-analyses regarding the proportion of remission\/recovery (symptomatic plus functional outcomes). Heterogeneity was measured employing\n                      <jats:italic>Q<\/jats:italic>\n                      statistics and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      test. To identify potential predictors, meta-regression analyses were conducted, as well as qualitative reporting of studies included in a systematic review. Sensitivity analyses were performed regarding different times of follow-up and type of studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493382102246X_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred articles (82 cohorts and 18 RCTs) were included in the meta-analysis. The pooled proportion of symptomatic remission was 54% (95%CI [30, 49\u201358]) over a mean follow-up period of 43.57\u00a0months (SD\u00a0=\u00a051.82) in 76 studies. After excluding RCT from the sample, the proportion of remission remained similar (55%). The pooled proportion of recovery was 32% (95%CI [27\u201336]) over a mean follow-up period of 71.85\u00a0months (SD\u00a0=\u00a073.54) in 40 studies. After excluding RCT from the sample, the recovery proportion remained the same. No significant effect of any sociodemographic or clinical predictor was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493382102246X_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Half of the patients are in symptomatic remission around 4\u00a0years after the FEP, while about a third show recovery after 5.5\u00a0years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2021.2246","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T06:16:25Z","timestamp":1635920185000},"source":"Crossref","is-referenced-by-count":78,"title":["Proportion and predictors of remission and recovery in first-episode psychosis: Systematic review and meta-analysis"],"prefix":"10.1192","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-7904","authenticated-orcid":false,"given":"Ana","family":"Catalan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0253-6111","authenticated-orcid":false,"given":"Anja","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-0767","authenticated-orcid":false,"given":"Gonzalo","family":"Salazar de Pablo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Vaquerizo-Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Mancebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-1571","authenticated-orcid":false,"given":"Borja","family":"Pedruzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-1608","authenticated-orcid":false,"given":"Claudia","family":"Aymerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-7233","authenticated-orcid":false,"given":"Marco","family":"Solmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-2785","authenticated-orcid":false,"given":"Miguel \u00c1.","family":"Gonz\u00e1lez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7438-9248","authenticated-orcid":false,"given":"Patxi","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fusar-Poli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"S092493382102246X_r17","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs130"},{"key":"S092493382102246X_r51","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20822"},{"key":"S092493382102246X_r63","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.08.054"},{"key":"S092493382102246X_r3","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs135"},{"key":"S092493382102246X_r20","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706007951"},{"key":"S092493382102246X_r73","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.01.024"},{"key":"S092493382102246X_r25","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770300115013"},{"key":"S092493382102246X_r71","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.09.013"},{"key":"S092493382102246X_r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.05.007"},{"key":"S092493382102246X_r18","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1176\/ajp.151.10.1409","article-title":"100 years of schizophrenia - a metaanalysis of the outcome literature","volume":"151","author":"Hegarty","year":"1994","journal-title":"Am J Psychiatr"},{"key":"S092493382102246X_r6","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000297663"},{"key":"S092493382102246X_r10","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.3.441"},{"key":"S092493382102246X_r64","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.07.031"},{"key":"S092493382102246X_r28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"S092493382102246X_r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"S092493382102246X_r27","doi-asserted-by":"publisher","DOI":"10.12968\/prps.2000.1.22.40994"},{"key":"S092493382102246X_r49","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04228-8"},{"key":"S092493382102246X_r11","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719001399"},{"key":"S092493382102246X_r31","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2313"},{"key":"S092493382102246X_r53","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-016-0741-2"},{"key":"S092493382102246X_r57","doi-asserted-by":"publisher","DOI":"10.2975\/31.1.2007.9.22"},{"key":"S092493382102246X_r35","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.03.014"},{"key":"S092493382102246X_r2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm164"},{"key":"S092493382102246X_r19","doi-asserted-by":"publisher","DOI":"10.3109\/10673229.2012.747804"},{"key":"S092493382102246X_r13","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-019-0091-y"},{"key":"S092493382102246X_r62","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1755-2"},{"key":"S092493382102246X_r21","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32832c920b"},{"key":"S092493382102246X_r9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013078"},{"key":"S092493382102246X_r47","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2015.0097"},{"key":"S092493382102246X_r65","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.09.018"},{"key":"S092493382102246X_r59","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.06.025"},{"key":"S092493382102246X_r60","doi-asserted-by":"publisher","DOI":"10.1080\/0954026021000016950"},{"key":"S092493382102246X_r72","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n1104"},{"key":"S092493382102246X_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2017.09.007"},{"key":"S092493382102246X_r12","first-page":"5","article-title":"Expert consensus guideline series - optimizing pharmacologic treatment of psychotic disorders - introduction: methods, commentary, and summary","volume":"64","author":"Kane","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"S092493382102246X_r16","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.117.201475"},{"key":"S092493382102246X_r46","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.01.008"},{"key":"S092493382102246X_r55","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051-5545.2012.tb00118.x"},{"key":"S092493382102246X_r29","volume-title":"Stata statistical software: release 16","year":"2019"},{"key":"S092493382102246X_r69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.11.002"},{"key":"S092493382102246X_r44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-224"},{"key":"S092493382102246X_r34","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000407"},{"key":"S092493382102246X_r5","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0623"},{"key":"S092493382102246X_r37","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-013-0701-3"},{"key":"S092493382102246X_r41","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-020-0102-z"},{"key":"S092493382102246X_r52","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19030324"},{"key":"S092493382102246X_r70","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.04.006"},{"key":"S092493382102246X_r66","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbi026"},{"key":"S092493382102246X_r1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00147-X"},{"key":"S092493382102246X_r24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60505-X"},{"key":"S092493382102246X_r36","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a006981"},{"key":"S092493382102246X_r39","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.017236"},{"key":"S092493382102246X_r68","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000433"},{"key":"S092493382102246X_r7","first-page":"164","article-title":"Effectiveness of long-acting injectable risperidone versus oral antipsychotics in the treatment of recent-onset schizophrenia: a case-control study","volume":"28","author":"Barrio","year":"2013","journal-title":"Int Clin Psychopharmacol"},{"key":"S092493382102246X_r58","doi-asserted-by":"publisher","DOI":"10.2975\/31.4.2008.280.290"},{"key":"S092493382102246X_r30","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.56.6.735"},{"key":"S092493382102246X_r42","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.04.017"},{"key":"S092493382102246X_r45","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.127753"},{"key":"S092493382102246X_r33","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201400316"},{"key":"S092493382102246X_r4","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20446"},{"key":"S092493382102246X_r50","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701003488"},{"key":"S092493382102246X_r56","doi-asserted-by":"publisher","DOI":"10.1080\/0954026021000016905"},{"key":"S092493382102246X_r26","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"S092493382102246X_r40","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-011-0218-2"},{"key":"S092493382102246X_r61","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0712-1"},{"key":"S092493382102246X_r67","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2019.07.001"},{"key":"S092493382102246X_r74","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.048942"},{"key":"S092493382102246X_r23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"S092493382102246X_r32","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820170047006"},{"key":"S092493382102246X_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.02.014"},{"key":"S092493382102246X_r43","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.12.001"},{"key":"S092493382102246X_r38","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.04.027"},{"key":"S092493382102246X_r54","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.6.7.993"},{"key":"S092493382102246X_r48","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30147-4"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S092493382102246X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T06:44:14Z","timestamp":1637649854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S092493382102246X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":74,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"alternative-id":["S092493382102246X"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2021.2246","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e69"}}