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In our study we employed a cross-diagnostic cluster analysis - to identify distinct subgroups within a cohort of depressed patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933822000207_sec2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A k-means cluster analysis\u2014 based on the domain scores of the Mood Spectrum Self-Report (MOODS-SR) questionnaire\u2014was performed on a data set of 300 adults with either bipolar or unipolar depression. After identifying groups, between-clusters comparisons were conducted on MOODS-SR domains and factors and on a set of sociodemographic, clinical and psychometric variables.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933822000207_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Three clusters were identified: one with intermediate depressive and poor manic symptomatology (Mild), one with severe depressive and poor manic symptomatology (Moderate), and a third one with severe depressive and intermediate manic symptomatology (Mixed). Across the clusters, bipolar patients were significantly less represented in the Mild one, while the DSM-5 \u201cMixed features\u201d specifier did not differentiate the groups. When compared to the other patients, those of Mixed cluster exhibited a stronger association with most of the illness-severity, quality of life, and outcomes measures considered. After performing pairwise comparisons significant differences between \u201cMixed\u201d and \u201cModerate\u201d clusters were restricted to: current and disease-onset age, psychotic ideation, suicidal attempts, hospitalization numbers, impulsivity levels and comorbidity for Cluster B personality disorder.<\/jats:p><\/jats:sec><jats:sec id=\"S0924933822000207_sec4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>In the present study, a clustering approach based on a spectrum exploration of mood symptomatology led to the identification of three transdiagnostic groups of patients. Consistent with our hypothesis, the magnitude of subthreshold (hypo)manic symptoms was related to a greater clinical severity, regardless of the main categorical diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1192\/j.eurpsy.2022.20","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T12:27:15Z","timestamp":1654000035000},"source":"Crossref","is-referenced-by-count":13,"title":["Exploration of mood spectrum symptoms during a major depressive episode: The impact of contrapolarity\u2014Results from a transdiagnostic cluster analysis on an Italian sample of unipolar and bipolar patients"],"prefix":"10.1192","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9692-2696","authenticated-orcid":false,"given":"Ludovico","family":"Mineo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-0601","authenticated-orcid":false,"given":"Alessandro","family":"Rodolico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8888","authenticated-orcid":false,"given":"Giorgio Alfredo","family":"Spedicato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-2101","authenticated-orcid":false,"given":"Andrea","family":"Aguglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-5250","authenticated-orcid":false,"given":"Carmen","family":"Concerto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cuomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Goracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Maina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5827-0853","authenticated-orcid":false,"given":"Andrea","family":"Fagiolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Aguglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"S0924933822000207_r30","first-page":"386","article-title":"Borderline personality disorder and bipolar disorder comorbidity in suicidal patients: diagnostic and therapeutic challenges","volume":"21","author":"Marcinko","year":"2009","journal-title":"Psychiatr Danub."},{"key":"S0924933822000207_r45","unstructured":"[45] Nykodym, T , Kraljevic, T , Hussami, N , Rao, A , Wang, A. 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