{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:46:54Z","timestamp":1793785614918,"version":"4.6.1"},"reference-count":181,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"unspecified","delay-in-days":247,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S092493382202315X_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although cognitive impairment is a core symptom of schizophrenia related to poorer outcomes in different functional domains, it still remains a major therapeutic challenge. To date, no comprehensive treatment guidelines for cognitive impairment in schizophrenia are implemented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493382202315X_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The aim of the present guidance paper is to provide a comprehensive meta-review of the current available evidence-based treatments for cognitive impairment in schizophrenia. The guidance is structured into three sections: pharmacological treatment, psychosocial interventions, and somatic treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493382202315X_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on the reviewed evidence, this European Psychiatric Association guidance recommends an appropriate pharmacological management as a fundamental starting point in the treatment of cognitive impairment in schizophrenia. In particular, second-generation antipsychotics are recommended for their favorable cognitive profile compared to first-generation antipsychotics, although no clear superiority of a single second-generation antipsychotic has currently been found. Anticholinergic and benzodiazepine burdens should be kept to a minimum, considering the negative impact on cognitive functioning. Among psychosocial interventions, cognitive remediation and physical exercise are recommended for the treatment of cognitive impairment in schizophrenia. Noninvasive brain stimulation techniques could be taken into account as add-on therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092493382202315X_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, there is definitive progress in the field, but further research is needed to develop specific treatments for cognitive impairment in schizophrenia. The dissemination of this guidance paper may promote the development of shared guidelines concerning the treatment of cognitive functions in schizophrenia, with the purpose to improve the quality of care and to achieve recovery in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2022.2315","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:43:07Z","timestamp":1662338587000},"source":"Crossref","is-referenced-by-count":121,"title":["European Psychiatric Association guidance on treatment of cognitive impairment in schizophrenia"],"prefix":"10.1192","volume":"65","author":[{"given":"Antonio","family":"Vita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Gaebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-9456","authenticated-orcid":false,"given":"Armida","family":"Mucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-9877","authenticated-orcid":false,"given":"Gabriele","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-3915","authenticated-orcid":false,"given":"Stefano","family":"Barlati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Maria","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Nibbio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Nordentoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-8003","authenticated-orcid":false,"given":"Til","family":"Wykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-7656","authenticated-orcid":false,"given":"Silvana","family":"Galderisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"S092493382202315X_r45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"S092493382202315X_r44","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2021.13"},{"key":"S092493382202315X_r71","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20081212"},{"key":"S092493382202315X_r107","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10060855"},{"key":"S092493382202315X_r119","doi-asserted-by":"publisher","DOI":"10.1016\/j.scog.2022.100238"},{"key":"S092493382202315X_r124","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13772"},{"key":"S092493382202315X_r94","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.01.001"},{"key":"S092493382202315X_r121","first-page":"546","article-title":"Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis","volume":"43","author":"Firth","year":"2017","journal-title":"Schizophr Bull"},{"key":"S092493382202315X_r18","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.4190"},{"key":"S092493382202315X_r5","volume-title":"Dementia praecox and paraphrenia, together with manic-depressive insanity and paranoia","author":"Kraepelin","year":"1989"},{"key":"S092493382202315X_r158","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720003670"},{"key":"S092493382202315X_r165","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00135"},{"key":"S092493382202315X_r160","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.06.014"},{"key":"S092493382202315X_r169","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2020.10.006"},{"key":"S092493382202315X_r140","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17176111"},{"key":"S092493382202315X_r175","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.115"},{"key":"S092493382202315X_r37","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700030336"},{"key":"S092493382202315X_r12","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12012"},{"key":"S092493382202315X_r31","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00524"},{"key":"S092493382202315X_r91","first-page":"CD007967","article-title":"Acetylcholinesterase inhibitors for schizophrenia","volume":"1","author":"Singh","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r79","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.10.002"},{"key":"S092493382202315X_r110","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa023"},{"key":"S092493382202315X_r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.07.001"},{"key":"S092493382202315X_r154","first-page":"75","article-title":"Electroconvulsive therapy and schizophrenia: a systematic review","volume":"5","author":"Ali","year":"2019","journal-title":"Mol Neuropsychiatry"},{"key":"S092493382202315X_r43","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2021.11"},{"key":"S092493382202315X_r52","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20384"},{"key":"S092493382202315X_r177","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00147"},{"key":"S092493382202315X_r9","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20734"},{"key":"S092493382202315X_r97","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.11.012"},{"key":"S092493382202315X_r178","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs104"},{"key":"S092493382202315X_r48","doi-asserted-by":"publisher","DOI":"10.1017\/9781108163682"},{"key":"S092493382202315X_r98","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719001995"},{"key":"S092493382202315X_r127","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2018.04.003"},{"key":"S092493382202315X_r29","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2021.06.007"},{"key":"S092493382202315X_r123","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714003110"},{"key":"S092493382202315X_r133","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-018-0243-2"},{"key":"S092493382202315X_r156","first-page":"CD011847","article-title":"Electroconvulsive therapy for treatment-resistant schizophrenia","volume":"3","author":"Sinclair","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r2","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20624"},{"key":"S092493382202315X_r11","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv056"},{"key":"S092493382202315X_r73","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.01.016"},{"key":"S092493382202315X_r116","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720000872"},{"key":"S092493382202315X_r146","first-page":"CD004025","article-title":"Music therapy for people with schizophrenia and schizophrenia-like disorders","volume":"5","author":"M\u00f6ssler","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r95","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.631589"},{"key":"S092493382202315X_r8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.schres.2004.09.007","article-title":"Identification of separable cognitive factors in schizophrenia","volume":"72","author":"Nuechterlein","year":"2004","journal-title":"Schizophr Res"},{"key":"S092493382202315X_r67","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1323870"},{"key":"S092493382202315X_r34","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq077"},{"key":"S092493382202315X_r93","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113285"},{"key":"S092493382202315X_r114","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.114232"},{"key":"S092493382202315X_r130","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.0015"},{"key":"S092493382202315X_r129","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v10.i8.187"},{"key":"S092493382202315X_r26","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20167"},{"key":"S092493382202315X_r35","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv163"},{"key":"S092493382202315X_r131","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.76.3.491"},{"key":"S092493382202315X_r132","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx146"},{"key":"S092493382202315X_r128","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.2490"},{"key":"S092493382202315X_r136","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm114"},{"key":"S092493382202315X_r72","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2019.10.013"},{"key":"S092493382202315X_r148","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.01.002"},{"key":"S092493382202315X_r59","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12374"},{"key":"S092493382202315X_r69","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01057-8"},{"key":"S092493382202315X_r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.08.019"},{"key":"S092493382202315X_r87","doi-asserted-by":"publisher","DOI":"10.1177\/0004867419893439"},{"key":"S092493382202315X_r100","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03545-z"},{"key":"S092493382202315X_r55","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2018.1488952"},{"key":"S092493382202315X_r162","first-page":"CD006081","article-title":"Transcranial magnetic stimulation (TMS) for schizophrenia","volume":"2015","author":"Dougall","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r103","first-page":"57","article-title":"Cognitive remediation \u2013 where are we now and what should we do next?","volume":"24","author":"Wykes","year":"2018","journal-title":"Off J Ital Soc Psychopathol"},{"key":"S092493382202315X_r38","first-page":"1","article-title":"European Psychiatric Association on assessment of cognitive impairment in schizophrenia","author":"Vita","year":"2022","journal-title":"Eur Psychiatry"},{"key":"S092493382202315X_r83","first-page":"CD011943","article-title":"Mirtazapine adjunct for people with schizophrenia","volume":"5","author":"Perry","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r179","unstructured":"[179] World Health Organization. ICD-11 guideline GCP network; 2021."},{"key":"S092493382202315X_r47","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2018.07.004"},{"key":"S092493382202315X_r172","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.008"},{"key":"S092493382202315X_r117","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.08.017"},{"key":"S092493382202315X_r153","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.12.025"},{"key":"S092493382202315X_r77","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12617"},{"key":"S092493382202315X_r180","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.04.065"},{"key":"S092493382202315X_r53","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.03.028"},{"key":"S092493382202315X_r4","volume-title":"Dementia praecox, or the group of schizophrenias","author":"Bleuler","year":"1969"},{"key":"S092493382202315X_r89","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4616-7"},{"key":"S092493382202315X_r17","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20760"},{"key":"S092493382202315X_r16","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.1592"},{"key":"S092493382202315X_r60","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105057002"},{"key":"S092493382202315X_r62","first-page":"1205","article-title":"Efficacy and safety of individual second-generation vs first-generation antipsychotics in first episode psychosis: a systematic review and meta-analysis","volume":"16","author":"Zhang","year":"2013","journal-title":"Int J Neuropsychopharmacol Off Sci J Coll Int Neuropsychopharmacol CINP"},{"key":"S092493382202315X_r99","doi-asserted-by":"publisher","DOI":"10.1177\/0004867419835028"},{"key":"S092493382202315X_r108","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbab022"},{"key":"S092493382202315X_r58","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114560184"},{"key":"S092493382202315X_r21","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3280ba4975"},{"key":"S092493382202315X_r118","doi-asserted-by":"publisher","DOI":"10.1177\/0004867419853348"},{"key":"S092493382202315X_r151","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.05.021"},{"key":"S092493382202315X_r104","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.0620"},{"key":"S092493382202315X_r157","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156510"},{"key":"S092493382202315X_r7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07010042"},{"key":"S092493382202315X_r40","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.01.011"},{"key":"S092493382202315X_r56","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001232"},{"key":"S092493382202315X_r92","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-018-0064-6"},{"key":"S092493382202315X_r155","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0000000000000737"},{"key":"S092493382202315X_r174","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796013000541"},{"key":"S092493382202315X_r168","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113656"},{"key":"S092493382202315X_r24","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20700"},{"key":"S092493382202315X_r85","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.0624"},{"key":"S092493382202315X_r64","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.06.008"},{"key":"S092493382202315X_r113","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291722000319"},{"key":"S092493382202315X_r120","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-019-01187-6"},{"key":"S092493382202315X_r65","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2019.01.015"},{"key":"S092493382202315X_r115","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171800418X"},{"key":"S092493382202315X_r66","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S94060"},{"key":"S092493382202315X_r80","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-017-0787-9"},{"key":"S092493382202315X_r126","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09493-9"},{"key":"S092493382202315X_r143","first-page":"CD012844","article-title":"Video games for people with schizophrenia","volume":"2","author":"Roberts","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r149","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01641-y"},{"key":"S092493382202315X_r138","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2017.05.002"},{"key":"S092493382202315X_r57","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1600-y"},{"key":"S092493382202315X_r63","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00039-0"},{"key":"S092493382202315X_r142","first-page":"CD009928","article-title":"Virtual reality for treatment compliance for people with serious mental illness","volume":"2014","author":"V\u00e4lim\u00e4ki","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r96","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.694394"},{"key":"S092493382202315X_r145","first-page":"CD004025","article-title":"Music therapy for people with schizophrenia and schizophrenia\u2010like disorders","volume":"2017","author":"Geretsegger","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"S092493382202315X_r176","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462312000086"},{"key":"S092493382202315X_r14","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20914"},{"key":"S092493382202315X_r112","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.031"},{"key":"S092493382202315X_r6","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq018"},{"key":"S092493382202315X_r164","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-016-9325-1"},{"key":"S092493382202315X_r15","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12261"},{"key":"S092493382202315X_r81","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610219000358"},{"key":"S092493382202315X_r150","first-page":"561","article-title":"Canadian network for mood and anxiety treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 4","volume":"61","author":"Milev","year":"2016","journal-title":"Neurostimulation Treatments Can J Psychiatry Rev Can Psychiatr"},{"key":"S092493382202315X_r170","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2020.03.002"},{"key":"S092493382202315X_r3","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20809"},{"key":"S092493382202315X_r61","doi-asserted-by":"publisher","DOI":"10.1017\/S146114570500516X"},{"key":"S092493382202315X_r134","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0912-8"},{"key":"S092493382202315X_r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.01.001"},{"key":"S092493382202315X_r86","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.013"},{"key":"S092493382202315X_r152","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2008.06.004"},{"key":"S092493382202315X_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.04.024"},{"key":"S092493382202315X_r41","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.12.001"},{"key":"S092493382202315X_r84","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.08.015"},{"key":"S092493382202315X_r74","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716002154"},{"key":"S092493382202315X_r28","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.06.079"},{"key":"S092493382202315X_r161","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8040416"},{"key":"S092493382202315X_r101","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.09.022"},{"key":"S092493382202315X_r159","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-020-09454-4"},{"key":"S092493382202315X_r42","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.08.003"},{"key":"S092493382202315X_r25","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4607"},{"key":"S092493382202315X_r54","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.6.633"},{"key":"S092493382202315X_r10","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx117"},{"key":"S092493382202315X_r68","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000790"},{"key":"S092493382202315X_r135","doi-asserted-by":"publisher","DOI":"10.3109\/08039488.2013.789074"},{"key":"S092493382202315X_r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.04.039"},{"key":"S092493382202315X_r141","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717001945"},{"key":"S092493382202315X_r144","doi-asserted-by":"publisher","DOI":"10.1080\/13651501.2018.1433857"},{"key":"S092493382202315X_r163","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv158"},{"key":"S092493382202315X_r51","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs097"},{"key":"S092493382202315X_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.wpsyc.2012.05.004"},{"key":"S092493382202315X_r105","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710000607"},{"key":"S092493382202315X_r139","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbz134"},{"key":"S092493382202315X_r181","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465815000168"},{"key":"S092493382202315X_r46","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"S092493382202315X_r78","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0029-9"},{"key":"S092493382202315X_r33","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.02.017"},{"key":"S092493382202315X_r76","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa093"},{"key":"S092493382202315X_r75","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09010017"},{"key":"S092493382202315X_r106","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1176\/appi.ajp.2007.07060906","article-title":"A meta-analysis of cognitive remediation in schizophrenia","volume":"164","author":"SR","year":"2007","journal-title":"Am J Psychiatry"},{"key":"S092493382202315X_r167","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.11.011"},{"key":"S092493382202315X_r1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20825"},{"key":"S092493382202315X_r49","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60239-6"},{"key":"S092493382202315X_r125","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.01.005"},{"key":"S092493382202315X_r171","doi-asserted-by":"publisher","DOI":"10.1177\/1073858420936167"},{"key":"S092493382202315X_r173","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032511-143134"},{"key":"S092493382202315X_r111","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2016.06.013"},{"key":"S092493382202315X_r90","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717001271"},{"key":"S092493382202315X_r20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.schres.2004.03.007","article-title":"Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis","volume":"71","author":"Sitskoorn","year":"2004","journal-title":"Schizophr Res"},{"key":"S092493382202315X_r50","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.10.018"},{"key":"S092493382202315X_r102","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.10.047"},{"key":"S092493382202315X_r109","doi-asserted-by":"publisher","DOI":"10.1111\/bjc.12320"},{"key":"S092493382202315X_r19","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1017\/S0033291717002902","article-title":"Familial aggregation of MATRICS consensus cognitive battery scores in a large sample of outpatients with schizophrenia and their unaffected relatives","volume":"48","author":"Mucci","year":"2018","journal-title":"Psychol Med"},{"key":"S092493382202315X_r147","doi-asserted-by":"publisher","DOI":"10.1002\/9781118753378.ch111"},{"key":"S092493382202315X_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.07.020"},{"key":"S092493382202315X_r166","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2021.102887"},{"key":"S092493382202315X_r82","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001245"},{"key":"S092493382202315X_r88","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.68"},{"key":"S092493382202315X_r70","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.03.034"},{"key":"S092493382202315X_r36","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000407"},{"key":"S092493382202315X_r137","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.07.022"},{"key":"S092493382202315X_r122","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv164"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S092493382202315X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T06:13:27Z","timestamp":1663913607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S092493382202315X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":181,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022]]}},"alternative-id":["S092493382202315X"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2022.2315","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e57"}}