{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:20:52Z","timestamp":1790288452675,"version":"4.1.0"},"reference-count":52,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"unspecified","delay-in-days":275,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924933822023227_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related to emotion regulation alterations observed during cognitive reappraisal in OCD.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023227_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>Adult patients with OCD (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) and healthy controls (HC; <jats:italic>n<\/jats:italic>\u00a0=\u00a030) were compared during performance of a functional magnetic resonance imaging cognitive reappraisal protocol. We used a free independent component analysis approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023227_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Analyses were focused on six networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (<jats:italic>F<\/jats:italic>(1,58)\u00a0=\u00a07.81, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023227_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2022.2322","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T10:15:55Z","timestamp":1664792155000},"source":"Crossref","is-referenced-by-count":5,"title":["A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal"],"prefix":"10.1192","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-2653","authenticated-orcid":false,"given":"V\u00edctor","family":"De la Pe\u00f1a-Arteaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-3258","authenticated-orcid":false,"given":"Pedro","family":"Morgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-9959","authenticated-orcid":false,"given":"Beatriz","family":"Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-1623","authenticated-orcid":false,"given":"S\u00f3nia","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-5126","authenticated-orcid":false,"given":"Nuno","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-6597","authenticated-orcid":false,"given":"Carles","family":"Soriano-Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-2445","authenticated-orcid":false,"given":"Maria","family":"Pic\u00f3-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"S0924933822023227_r2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076358"},{"key":"S0924933822023227_r10","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715001026"},{"key":"S0924933822023227_r23","first-page":"1","article-title":"Criterion validity of the Yale-Brown obsessive-compulsive scale second edition for diagnosis of obsessive-compulsive disorder in adults","volume":"9","author":"Castro-Rodrigues","year":"2018","journal-title":"Front Psych"},{"key":"S0924933822023227_r18","first-page":"22","article-title":"The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"S0924933822023227_r35","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000437"},{"key":"S0924933822023227_r41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.003"},{"key":"S0924933822023227_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.06.001"},{"key":"S0924933822023227_r31","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1048"},{"key":"S0924933822023227_r46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.11.021"},{"key":"S0924933822023227_r1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06751.x"},{"key":"S0924933822023227_r49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2020.08.435"},{"key":"S0924933822023227_r38","doi-asserted-by":"publisher","DOI":"10.2466\/03.20.PR0.114k22w4"},{"key":"S0924933822023227_r50","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.10.017"},{"key":"S0924933822023227_r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.06.009"},{"key":"S0924933822023227_r11","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.559268"},{"key":"S0924933822023227_r33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.027"},{"key":"S0924933822023227_r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2012.01.001"},{"key":"S0924933822023227_r52","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00929-9"},{"key":"S0924933822023227_r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.11.014"},{"key":"S0924933822023227_r14","first-page":"373","article-title":"Brain networks alterations in cocaine use and gambling disorders during emotion regulation","volume":"11","author":"Pic\u00f3-P\u00e9rez","year":"2022","journal-title":"J Behav Addict."},{"key":"S0924933822023227_r27","volume-title":"International affective picture system (IAPS). 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