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Psychiatr."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924933822023276_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Patients with anorexia nervosa (AN) show impaired decision-making ability, but it is still unclear if this is a trait marker (i.e., being associated with AN at any stage of the disease) or a state parameter of the disease (i.e., being present only in acutely ill patients), and if it has endophenotypic characteristics. The aim of this study was to determine the endophenotypic, and state- or trait-associated nature of decision-making impairment in AN.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023276_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>Ninety-one patients with acute AN (A-AN), 90 unaffected relatives (UR), 23 patients remitted from AN (R-AN), and 204 healthy controls (HC) carried out the Iowa gambling task (IGT). Prospective valence learning (PVL) model was employed to distinguish the cognitive dimensions underlying the decision-making process, that is, learning, consistency, feedback sensitivity, and loss aversion. IGT performance and decision-making dimensions were compared among groups to assess whether they had endophenotypic (i.e., being present in A-AN, UR, and R-AN, but not in HC) and\/or trait-associated features (i.e., present in A-AN and R-AN but not in HC).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023276_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Patients with A-AN had lower performance at the IGT (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), while UR, R-AN, and HC had comparable results. PVL-feedback sensitivity was lower in patients with R-AN and A-AN than in HC (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023276_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Alteration of decision-making ability did not show endophenotypic features. Impaired decision-making seems a state-associated characteristic of AN, resulting from the interplay between trait-associated low feedback sensitivity and state-associated features of the disease.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2022.2327","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T08:29:28Z","timestamp":1666340968000},"source":"Crossref","is-referenced-by-count":15,"title":["Is decision-making impairment an endophenotype of anorexia nervosa?"],"prefix":"10.1192","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-338X","authenticated-orcid":false,"given":"Laura","family":"Di Lodovico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Versini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-5170","authenticated-orcid":false,"given":"Mathieu","family":"Lachatre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2731-4582","authenticated-orcid":false,"given":"Jacopo","family":"Marcheselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-9938","authenticated-orcid":false,"given":"Nicolas","family":"Ramoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-3676","authenticated-orcid":false,"given":"Philip","family":"Gorwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"S0924933822023276_r25","doi-asserted-by":"publisher","DOI":"10.1080\/03640210802352992"},{"key":"S0924933822023276_r1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"S0924933822023276_r22","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00898"},{"key":"S0924933822023276_r21","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S103821"},{"key":"S0924933822023276_r49","unstructured":"[49] R Core Team. 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