{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:22:23Z","timestamp":1791580943655,"version":"4.3.4"},"reference-count":124,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"unspecified","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924933822023483_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Characterizing neurocognitive endophenotypes of mental illnesses (MIs) could be useful for identifying at-risk individuals, increasing early diagnosis, improving disease subtyping, and proposing therapeutic strategies to reduce the negative effects of the symptoms, in addition to serving as a scientific basis to unravel the physiopathology of the disease. However, a standardized algorithm to determine cognitive endophenotypes has not yet been developed. The main objective of this study was to present a method for the identification of endophenotypes in MI research.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023483_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>For this purpose, a 14-expert working group used a scoping review methodology and designed a method that includes a scoring template with five criteria and indicators, a strategy for their verification, and a decision tree.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933822023483_sec3\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>This work is ongoing since it is necessary to obtain external validation of the applicability of the method in future research.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2022.2348","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T09:34:06Z","timestamp":1669628046000},"source":"Crossref","is-referenced-by-count":3,"title":["MICEmi: A method to identify cognitive endophenotypes of mental illnesses"],"prefix":"10.1192","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-7349","authenticated-orcid":false,"given":"Patricia","family":"Correa-Ghisays","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-6688","authenticated-orcid":false,"given":"Joan","family":"Vicent S\u00e1nchez-Ort\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicent","family":"Balanz\u00e1-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-7850","authenticated-orcid":false,"given":"Inmaculada","family":"Fuentes-Dur\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-6263","authenticated-orcid":false,"given":"Anabel","family":"Martinez-Aran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-9053","authenticated-orcid":false,"given":"Lara","family":"Ruiz-Bolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Correa-Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-9717","authenticated-orcid":false,"given":"Juan Carlos","family":"Ruiz-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Selva-Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-8235","authenticated-orcid":false,"given":"Joan","family":"Vila-Franc\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-2160","authenticated-orcid":false,"given":"Diego","family":"Macias Saint-Gerons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0347-5442","authenticated-orcid":false,"given":"Constanza","family":"San-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-5352","authenticated-orcid":false,"given":"Rosa","family":"Ayesa-Arriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-2204","authenticated-orcid":false,"given":"Rafael","family":"Tabar\u00e9s-Seisdedos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"S0924933822023483_r44","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00156-6"},{"key":"S0924933822023483_r42","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"S0924933822023483_r122","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110283"},{"key":"S0924933822023483_r123","doi-asserted-by":"publisher","DOI":"10.1159\/000513495"},{"key":"S0924933822023483_r124","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12961"},{"key":"S0924933822023483_r51","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-5-49"},{"key":"S0924933822023483_r47","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00232-4"},{"key":"S0924933822023483_r98","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.08.033"},{"key":"S0924933822023483_r87","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-012-1262-2"},{"key":"S0924933822023483_r19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.01.003"},{"key":"S0924933822023483_r94","doi-asserted-by":"publisher","DOI":"10.1016\/j.scog.2014.09.005"},{"key":"S0924933822023483_r115","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-019-00993-3"},{"key":"S0924933822023483_r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.11.029"},{"key":"S0924933822023483_r89","doi-asserted-by":"publisher","DOI":"10.1080\/21622965.2012.709421"},{"key":"S0924933822023483_r30","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-015-0605-x"},{"key":"S0924933822023483_r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.07.038"},{"key":"S0924933822023483_r81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.11.019"},{"key":"S0924933822023483_r67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00529.x"},{"key":"S0924933822023483_r80","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2010.11.007"},{"key":"S0924933822023483_r113","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx141"},{"key":"S0924933822023483_r121","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.113931"},{"key":"S0924933822023483_r54","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.10.1963"},{"key":"S0924933822023483_r77","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01532.x"},{"key":"S0924933822023483_r72","doi-asserted-by":"publisher","DOI":"10.1080\/13803390903201777"},{"key":"S0924933822023483_r99","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715001324"},{"key":"S0924933822023483_r110","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2018.05.009"},{"key":"S0924933822023483_r111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.08.029"},{"key":"S0924933822023483_r96","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12335"},{"key":"S0924933822023483_r60","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30330"},{"key":"S0924933822023483_r55","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.10.1980"},{"key":"S0924933822023483_r97","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2015.05.013"},{"key":"S0924933822023483_r112","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.08.067"},{"key":"S0924933822023483_r83","doi-asserted-by":"publisher","DOI":"10.1037\/a0024944"},{"key":"S0924933822023483_r92","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.639804"},{"key":"S0924933822023483_r117","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718001642"},{"key":"S0924933822023483_r2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.4.636"},{"key":"S0924933822023483_r79","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp026"},{"key":"S0924933822023483_r120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.07.008"},{"key":"S0924933822023483_r36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01910.x"},{"key":"S0924933822023483_r65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.016"},{"key":"S0924933822023483_r75","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.02.012"},{"key":"S0924933822023483_r82","doi-asserted-by":"publisher","DOI":"10.1159\/000317577"},{"key":"S0924933822023483_r50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.03.005"},{"key":"S0924933822023483_r33","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001948"},{"key":"S0924933822023483_r74","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.04.013"},{"key":"S0924933822023483_r28","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.09.046"},{"key":"S0924933822023483_r56","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.12.2269"},{"key":"S0924933822023483_r43","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.109.2.252"},{"key":"S0924933822023483_r18","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.184"},{"key":"S0924933822023483_r7","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12894"},{"key":"S0924933822023483_r45","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10644"},{"key":"S0924933822023483_r27","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12133"},{"key":"S0924933822023483_r8","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00709"},{"key":"S0924933822023483_r101","doi-asserted-by":"publisher","DOI":"10.1038\/srep32597"},{"key":"S0924933822023483_r49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00122.x"},{"key":"S0924933822023483_r71","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2010.483250"},{"key":"S0924933822023483_r90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01903.x"},{"key":"S0924933822023483_r31","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.140645"},{"key":"S0924933822023483_r102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2016.04.002"},{"key":"S0924933822023483_r114","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.10.013"},{"key":"S0924933822023483_r34","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12215"},{"key":"S0924933822023483_r48","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200310000-00016"},{"key":"S0924933822023483_r64","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.07.020"},{"key":"S0924933822023483_r66","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.11.003"},{"key":"S0924933822023483_r26","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-015-0657-2"},{"key":"S0924933822023483_r40","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"S0924933822023483_r68","doi-asserted-by":"publisher","DOI":"10.1080\/13803390802036092"},{"key":"S0924933822023483_r14","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12270"},{"key":"S0924933822023483_r17","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.167239"},{"key":"S0924933822023483_r73","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.07.011"},{"key":"S0924933822023483_r76","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08091351"},{"key":"S0924933822023483_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.06.014"},{"key":"S0924933822023483_r70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00857.x"},{"key":"S0924933822023483_r93","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000640"},{"key":"S0924933822023483_r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.12.234"},{"key":"S0924933822023483_r63","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm205"},{"key":"S0924933822023483_r11","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399402004751"},{"key":"S0924933822023483_r86","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000857"},{"key":"S0924933822023483_r104","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.03.041"},{"key":"S0924933822023483_r118","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ajp.2019.04.005","article-title":"Social cognitions in siblings of patients with schizophrenia: a comparison with patients with schizophrenia and healthy controls-a cross-sectional study","volume":"43","author":"Grover","year":"2019","journal-title":"Asian J Psychiatr"},{"key":"S0924933822023483_r1","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3723.711"},{"key":"S0924933822023483_r119","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.10.053"},{"key":"S0924933822023483_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.11.012"},{"key":"S0924933822023483_r59","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.5.813"},{"key":"S0924933822023483_r23","first-page":"108","article-title":"Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates","volume":"6","author":"Balanza-Martinez","year":"2015","journal-title":"Front Physiol"},{"key":"S0924933822023483_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.12.011"},{"key":"S0924933822023483_r3","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw157"},{"key":"S0924933822023483_r108","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12637"},{"key":"S0924933822023483_r46","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01641-4"},{"key":"S0924933822023483_r37","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2015.00105"},{"key":"S0924933822023483_r105","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.10.032"},{"key":"S0924933822023483_r100","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.09.005"},{"key":"S0924933822023483_r22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01601.x"},{"key":"S0924933822023483_r53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.05.041"},{"key":"S0924933822023483_r69","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.02.018"},{"key":"S0924933822023483_r91","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2012.665478"},{"key":"S0924933822023483_r6","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2015.13.1.94"},{"key":"S0924933822023483_r85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01733.x"},{"key":"S0924933822023483_r116","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.06.059"},{"key":"S0924933822023483_r20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.04.028"},{"key":"S0924933822023483_r78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02215.x"},{"key":"S0924933822023483_r15","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32221"},{"key":"S0924933822023483_r24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.009"},{"key":"S0924933822023483_r10","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852918001074"},{"key":"S0924933822023483_r29","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00403"},{"key":"S0924933822023483_r84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.07.037"},{"key":"S0924933822023483_r107","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.03.001"},{"key":"S0924933822023483_r88","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.02.028"},{"key":"S0924933822023483_r109","doi-asserted-by":"publisher","DOI":"10.1177\/1087054714545536"},{"key":"S0924933822023483_r95","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22332"},{"key":"S0924933822023483_r12","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00321-7"},{"key":"S0924933822023483_r106","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.03.021"},{"key":"S0924933822023483_r61","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.04.003"},{"key":"S0924933822023483_r58","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.08.030"},{"key":"S0924933822023483_r52","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2004.08.004"},{"key":"S0924933822023483_r103","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1581-y"},{"key":"S0924933822023483_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.11.006"},{"key":"S0924933822023483_r13","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708004832"},{"key":"S0924933822023483_r41","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1123"},{"key":"S0924933822023483_r57","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000207360.70337.7e"},{"key":"S0924933822023483_r62","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.06.020"},{"key":"S0924933822023483_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.05.019"},{"key":"S0924933822023483_r35","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07471"},{"key":"S0924933822023483_r38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.06.019"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933822023483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T13:31:45Z","timestamp":1671024705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933822023483\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":124,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022]]}},"alternative-id":["S0924933822023483"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2022.2348","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e85"}}