{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:52:39Z","timestamp":1772826759557,"version":"3.50.1"},"reference-count":15,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"unspecified","delay-in-days":163,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S092493382302415X_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Major depressive disorder (MDD) is highly prevalent across Europe. While evidence-based treatments exist, many people with MDD have their condition undetected and\/or untreated. This study aimed to assess the cost-effectiveness of reducing treatment gaps using a modeling approach.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S092493382302415X_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>A decision-tree model covering a 27-month time horizon was used. This followed a care pathway where MDD could be detected or not, and where different forms of treatment could be provided. Expected costs pertaining to Germany, Hungary, Italy, Portugal, Sweden, and the UK were calculated and quality-adjusted life years (QALYs) were estimated. The incremental costs per QALY of reducing detection and treatment gaps were estimated.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S092493382302415X_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>The expected costs with a detection gap of 69% and treatment gap of 50% were \u20ac1236 in Germany, \u20ac476 in Hungary, \u20ac1413 in Italy, \u20ac938 in Portugal, \u20ac2093 in Sweden, and \u20ac1496 in the UK. The incremental costs per QALY of reducing the detection gap to 50% ranged from \u20ac2429 in Hungary to \u20ac10,686 in Sweden. The figures for reducing the treatment gap to 25% ranged from \u20ac3146 in Hungary to \u20ac13,843 in Sweden.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S092493382302415X_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Reducing detection and treatment gaps, and maintaining current patterns of care, is likely to increase healthcare costs in the short term. However, outcomes are improved, and reducing these gaps to 50 and 25%, respectively, appears to be a cost-effective use of resources.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2023.2415","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T11:21:28Z","timestamp":1686655288000},"source":"Crossref","is-referenced-by-count":4,"title":["Economic impact of reducing treatment gaps in depression"],"prefix":"10.1192","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-4502","authenticated-orcid":false,"given":"Paul","family":"McCrone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-6952","authenticated-orcid":false,"given":"Allan H.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8447-1453","authenticated-orcid":false,"given":"Roland","family":"Zahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-2626","authenticated-orcid":false,"given":"Jonas","family":"Eberhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-3989","authenticated-orcid":false,"given":"Danuta","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-8456","authenticated-orcid":false,"given":"Paolo","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-1419","authenticated-orcid":false,"given":"Judit","family":"Balazs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-6772","authenticated-orcid":false,"given":"Jose","family":"Caldas-de-Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3522-0620","authenticated-orcid":false,"given":"Andrea","family":"Ulrichsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-0675","authenticated-orcid":false,"given":"Vladmir","family":"Carli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-6672","authenticated-orcid":false,"given":"Ana","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-8071","authenticated-orcid":false,"given":"Giandomenico","family":"Schiena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-6432","authenticated-orcid":false,"given":"Vinciane","family":"Quoidbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Strawbridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"S092493382302415X_r2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.5.513"},{"key":"S092493382302415X_r12","doi-asserted-by":"publisher","DOI":"10.1037\/a0013786"},{"key":"S092493382302415X_r11","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715000951"},{"key":"S092493382302415X_r7","unstructured":"[7] Strawbridge, R. 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International Comparisons of Health Prices and Volumes: New Findings; 2017."},{"key":"S092493382302415X_r1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00047-5"},{"key":"S092493382302415X_r6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076882"},{"key":"S092493382302415X_r4","unstructured":"[4] Depression: The Treatment and Management of Depression in Adults (Updated Edition); 2010."},{"key":"S092493382302415X_r15","volume-title":"Paying the price: The cost of mental health care in England to 2026","author":"McCrone","year":"2008"},{"key":"S092493382302415X_r9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2009.00145.x"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S092493382302415X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T08:14:19Z","timestamp":1691050459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S092493382302415X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"alternative-id":["S092493382302415X"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2023.2415","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e57"}}