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Psychiatr."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924933823024185_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Current evidence on the risk of admission- or medication-requiring psychiatric sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited to selected populations, short durations, and loss to follow-up. This study examined if SARS-CoV-2 infection was associated with increased long-term risk of psychiatric admissions and <jats:italic>de novo<\/jats:italic> prescription of psychoactive medication in the general population of Denmark.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933823024185_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>Adults (\u226518 years) were assigned to either the control or SARS-CoV-2 group based on polymerase chain reaction (PCR) tests between 1 January 2020 and 27 November 2021. Infected subjects were matched 1:5 to control subjects by propensity score. Incidence rate ratios (IRRs) were calculated. Adjusted Cox regression was applied to the unmatched population with SARS-CoV-2 infection as a time-dependent covariate. Follow-up time was 12 months or until the end of the study.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933823024185_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>A total of 4,585,083 adults were included in the study. Approximately 342,084 had a PCR-confirmed SARS-CoV-2 infection and were matched 1:5 with 1,697,680 controls. The IRR for psychiatric admission was 0.79 in the matched population (95% confidence interval [CI]: 0.73\u20130.85, <jats:italic>p<\/jats:italic> &lt; 0.001). In the unmatched population, the adjusted hazard ratios (aHR) for psychiatric admission were either below 1.00 or with a 95% CI lower limit of 1.01. SARS-CoV-2 infection was associated with an increased risk of <jats:italic>de novo<\/jats:italic> prescription of psychoactive medication in both the matched (IRR 1.06, 95% CI: 1.02\u20131.11, <jats:italic>p<\/jats:italic> &lt; 0.01) and unmatched population (HR 1.31, 95% CI: 1.28\u20131.34, <jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933823024185_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>We found a signal of increased use of psychoactive medication, specifically benzodiazepines, among SARS-CoV-2-positive persons, but the risk of psychiatric admissions did not increase.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2023.2418","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T07:33:01Z","timestamp":1686123181000},"source":"Crossref","is-referenced-by-count":1,"title":["SARS-CoV-2 and risk of psychiatric hospital admission and use of psychopharmaceuticals: A nationwide registry study of 4,585,083 adult Danish citizens"],"prefix":"10.1192","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-7639","authenticated-orcid":false,"given":"Valdemar","family":"R\u00f8mer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-3655","authenticated-orcid":false,"given":"Pradeesh","family":"Sivapalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-7526","authenticated-orcid":false,"given":"Josefin","family":"Ekl\u00f6f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-7455","authenticated-orcid":false,"given":"Susanne D.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5552-0095","authenticated-orcid":false,"given":"Zitta B.","family":"Harboe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4209-2778","authenticated-orcid":false,"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-3636","authenticated-orcid":false,"given":"Theis","family":"Itenov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-0521","authenticated-orcid":false,"given":"Jens-Ulrik S.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"S0924933823024185_r2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12603"},{"key":"S0924933823024185_r30","doi-asserted-by":"publisher","DOI":"10.3758\/s13423-016-1026-5"},{"key":"S0924933823024185_r42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.07.018"},{"key":"S0924933823024185_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116884"},{"key":"S0924933823024185_r36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.04.013"},{"key":"S0924933823024185_r39","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32831a473d"},{"key":"S0924933823024185_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105007"},{"key":"S0924933823024185_r4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95565-8"},{"key":"S0924933823024185_r28","first-page":"188","article-title":"Charlson comorbidity index: ICD-9 update and ICD-10 translation","volume":"12","author":"Glasheen","year":"2019","journal-title":"Am Health Drug Benefits"},{"key":"S0924933823024185_r44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264019"},{"key":"S0924933823024185_r26","doi-asserted-by":"publisher","DOI":"10.2807\/ese.17.17.20155-en"},{"key":"S0924933823024185_r46","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100421"},{"key":"S0924933823024185_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.npbr.2020.05.008"},{"key":"S0924933823024185_r20","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30168-1"},{"key":"S0924933823024185_r34","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201500547"},{"key":"S0924933823024185_r7","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30287-X"},{"key":"S0924933823024185_r22","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"S0924933823024185_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.06.020"},{"key":"S0924933823024185_r38","unstructured":"[38] (Sundhedsstyrelsen) DHA. 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