{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:14:53Z","timestamp":1784204093445,"version":"3.55.0"},"reference-count":43,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"unspecified","delay-in-days":254,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924933823024392_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>The menopause transition is a vulnerable period that can be associated with changes in mood and cognition. The present study aimed to investigate whether a symptomatic menopausal transition increases the risks of depression, anxiety, and sleep disorders.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933823024392_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>This population-based, retrospective cohort study analysed data from five electronic health record databases in South Korea. Women aged 45\u201364\u00a0years with and without symptomatic menopausal transition were matched 1:1 using propensity-score matching. Subgroup analyses were conducted according to age and use of hormone replacement therapy (HRT). A primary analysis of 5-year follow-up data was conducted, and an intention-to-treat analysis was performed to identify different risk windows over 5 or 10\u00a0years. The primary outcome was first-time diagnosis of depression, anxiety, and sleep disorder. We used Cox proportional hazard models and a meta-analysis to calculate the summary hazard ratio (HR) estimates across the databases.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933823024392_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Propensity-score matching resulted in a sample of 17,098 women. Summary HRs for depression (2.10; 95% confidence interval [CI] 1.63\u20132.71), anxiety (1.64; 95% CI 1.01\u20132.66), and sleep disorders (1.47; 95% CI 1.16\u20131.88) were higher in the symptomatic menopausal transition group. In the subgroup analysis, the use of HRT was associated with an increased risk of depression (2.21; 95% CI 1.07\u20134.55) and sleep disorders (2.51; 95% CI 1.25\u20135.04) when compared with non-use of HRT.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933823024392_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Our findings suggest that women with symptomatic menopausal transition exhibit an increased risk of developing depression, anxiety, and sleep disorders. Therefore, women experiencing a symptomatic menopausal transition should be monitored closely so that interventions can be applied early.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2023.2439","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T06:18:26Z","timestamp":1694499506000},"source":"Crossref","is-referenced-by-count":25,"title":["Impact of symptomatic menopausal transition on the occurrence of depression, anxiety, and sleep disorders: A real-world multi-site study"],"prefix":"10.1192","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-9862","authenticated-orcid":false,"given":"Dong 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