{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:18:07Z","timestamp":1772529487157,"version":"3.50.1"},"reference-count":53,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"unspecified","delay-in-days":269,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NV16-32791A"],"award-info":[{"award-number":["NV16-32791A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924933824017619_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>We need to better understand the risk factors and predictors of medication-related weight gain to improve metabolic health of individuals with schizophrenia. This study explores how trajectories of antipsychotic medication (AP) use impact body weight early in the course of schizophrenia.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933824017619_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>We recruited 92 participants with first-episode psychosis (FEP, <jats:italic>n<\/jats:italic>\u00a0=\u00a092) during their first psychiatric hospitalization. We prospectively collected weight, body mass index (BMI), metabolic markers, and exact daily medication exposure during 6-week hospitalization. We quantified the trajectory of AP medication changes and AP polypharmacy using a novel approach based on meta-analytical ranking of medications and tested it as a predictor of weight gain together with traditional risk factors.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933824017619_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Most people started treatment with risperidone (<jats:italic>n<\/jats:italic>\u00a0=\u00a057), followed by olanzapine (<jats:italic>n<\/jats:italic>\u00a0=\u00a029). Then, 48% of individuals remained on their first prescribed medication, while 33% of people remained on monotherapy. Almost half of the individuals (39\/92) experienced escalation of medications, mostly switch to AP polypharmacy (90%). Only baseline BMI was a predictor of BMI change. Individuals in the top tercile of weight gain, compared to those in the bottom tercile, showed lower follow-up symptoms, a trend for longer prehospitalization antipsychotic treatment, and greater exposure to metabolically problematic medications.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933824017619_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Early in the course of illness, during inpatient treatment, baseline BMI is the strongest and earliest predictor of weight gain on APs and is a better predictor than type of medication, polypharmacy, or medication switches. Baseline BMI predicted weight change over a period of weeks, when other traditional predictors demonstrated a much smaller effect.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2024.1761","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T02:22:43Z","timestamp":1727317363000},"source":"Crossref","is-referenced-by-count":3,"title":["Trajectories of daily antipsychotic use and weight gain in people hospitalized for the first episode of psychosis"],"prefix":"10.1192","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7061-3043","authenticated-orcid":false,"given":"Kristyna","family":"Vochoskova","sequence":"first","affiliation":[{"name":"National Institute of Mental Health"},{"name":"Third Faculty of Medicine, Charles University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean R.","family":"McWhinney","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Dalhousie University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-2965","authenticated-orcid":false,"given":"Marketa","family":"Fialova","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"},{"name":"Third Faculty of Medicine, Charles University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-3478","authenticated-orcid":false,"given":"Marian","family":"Kolenic","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"},{"name":"Third Faculty of Medicine, Charles University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-696X","authenticated-orcid":false,"given":"Filip","family":"Spaniel","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"},{"name":"Third Faculty of Medicine, Charles University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-1388","authenticated-orcid":false,"given":"Petra","family":"Furstova","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Boron","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital Bohnice"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurai","family":"Okaji","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital Bohnice"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Trancik","sequence":"additional","affiliation":[{"name":"Psychiatric Hospital Bohnice"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-8458","authenticated-orcid":false,"given":"Tomas","family":"Hajek","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"},{"name":"Department of Psychiatry, Dalhousie University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"S0924933824017619_r52","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.066217"},{"key":"S0924933824017619_r24","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31826866db"},{"key":"S0924933824017619_r7","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0416"},{"key":"S0924933824017619_r22","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181bf613e"},{"key":"S0924933824017619_r13","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00263"},{"key":"S0924933824017619_r35","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105058978"},{"key":"S0924933824017619_r39","unstructured":"[39] Doporu\u010den\u00e9 postupy psychiatrick\u00e9 p\u00e9\u010de Psychiatrick\u00e9 spole\u010dnosti \u010cLS JEP. https:\/\/postupy-pece.psychiatrie.cz\/specialni-psychiatrie\/f2-schizofrenie\/lecba-akutni-epizody-schizofrenie; Published 2018. 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