{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:54:02Z","timestamp":1791834842666,"version":"4.3.4"},"reference-count":0,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"unspecified","delay-in-days":237,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Bipolar disorder (BD) is commonly comorbid with other psychiatric conditions, such as obsessive-compulsive disorder (OCD). Despite increasing interest in this comorbidity, quantitative data on its clinical characteristics remain limited. This systematic review and meta-analysis aimed to evaluate the clinical impact of OCD comorbidity in BD by comparing individuals with BD and OCD (BD-OCD) to those with BD without OCD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We systematically searched the PubMed\/MEDLINE, Scopus, PsycINFO, and Web of Science databases up to April 15, 2024. Meta-analyses were conducted to compare BD-OCD and BD without OCD groups across multiple clinical domains.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n From 11,959 initial records screened, 26 studies were included in the qualitative synthesis, with 22 eligible for meta-analysis. Individuals with BD-OCD showed higher odds of experiencing chronic mood episodes (OR\u00a0=\u00a09.42; 95%CI\u00a0=\u00a02.23, 39.9), rapid cycling (OR\u00a0=\u00a01.92; 95%CI\u00a0=\u00a01.04, 3.53), comorbid eating disorders (OR\u00a0=\u00a03.37; 95%CI\u00a0=\u00a01.99, 5.7), panic disorder (OR\u00a0=\u00a03.3; 95%CI\u00a0=\u00a02.11, 5.2), substance use disorders (OR\u00a0=\u00a01.39; 95%CI\u00a0=\u00a01.02, 1.89), and lifetime suicide attempts (OR\u00a0=\u00a01.85; 95%CI\u00a0=\u00a01.21, 2.84). Additionally, they presented earlier onset of BD (SMD\u00a0=\u00a0-0.27; 95%CI\u00a0=\u00a0-0.52, \u22120.01) and reduced functioning (SMD\u00a0=\u00a0-0.42; 95%CI\u00a0=\u00a0-0.59, \u22120.24). Most data were derived from adult populations, limiting the evidence available for children and adolescents.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n BD-OCD presents a more severe and complex clinical profile, requiring specialized assessment and integrated treatment approaches. Identifying these features may support earlier recognition and inform personalized interventions for this population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2025.10087","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T03:35:53Z","timestamp":1756179353000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: a systematic review and meta-analysis"],"prefix":"10.1192","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-1181","authenticated-orcid":false,"given":"Michele","family":"De Prisco","sequence":"first","affiliation":[{"name":"Universitat de Barcelona (UB)"},{"name":"Hosp\u00ectal Clinic de Barcelona"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)"},{"name":"Instituto de Salud Carlos III"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-1149","authenticated-orcid":false,"given":"Cristiana","family":"Tapoi","sequence":"additional","affiliation":[{"name":"Prof. Dr. Alexandru Obregia Clinical Psychiatry Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5961-6032","authenticated-orcid":false,"given":"Vincenzo","family":"Oliva","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona (UB)"},{"name":"Hosp\u00ectal Clinic de Barcelona"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)"},{"name":"Instituto de Salud Carlos III"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-1537","authenticated-orcid":false,"given":"Robertas","family":"Strumila","sequence":"additional","affiliation":[{"name":"CHU Montpellier"},{"name":"University of Montpellier, CNRS, INSERM"},{"name":"Vilnius University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-5097","authenticated-orcid":false,"given":"Christine","family":"Takami","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-2096","authenticated-orcid":false,"given":"Nicolaja","family":"Girone","sequence":"additional","affiliation":[{"name":"University of Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-5897","authenticated-orcid":false,"given":"Monica","family":"Macellaro","sequence":"additional","affiliation":[{"name":"University of Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2683-3257","authenticated-orcid":false,"given":"Juliana Braga","family":"de Salles Andrade","sequence":"additional","affiliation":[{"name":"D\u2019Or Institute for Research and Education - IDOR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1908-4026","authenticated-orcid":false,"given":"Christian Nikolaus","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Heidelberg University"},{"name":"Heidelberg University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-0053","authenticated-orcid":false,"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona (UB)"},{"name":"Hosp\u00ectal Clinic de Barcelona"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)"},{"name":"Instituto de Salud Carlos III"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-7126","authenticated-orcid":false,"given":"Giovanna","family":"Fico","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona (UB)"},{"name":"Hosp\u00ectal Clinic de Barcelona"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,8,26]]},"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933825100874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T08:56:06Z","timestamp":1763024166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933825100874\/type\/journal_article"}},"subtitle":["OCD in BD: A Review on Clinical Impact"],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0924933825100874"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2025.10087","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e142"}}