{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:01:06Z","timestamp":1792036866703,"version":"4.4.0"},"reference-count":55,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"unspecified","delay-in-days":245,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933825100989_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benzodiazepines (BZ) are widely prescribed to patients with severe mental illnesses, yet their long-term impact on global health remains underinvestigated. While their symptomatic benefits are acknowledged, data on their associations with quality of life (QoL), metabolic comorbidities, and side effects are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933825100989_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, we analyzed clinical data from 1,248 patients with schizophrenia, bipolar disorder (BD), or major depressive disorder at a psychiatric center in Marseille, France. Associations between BZ use and key outcomes \u2013 including QoL (Short Form Health Survey [SF-36], EuroQol-5 Dimensions [EQ-5D], and Schizophrenia Quality of Life Questionnaire - 18 items [SQoL-18]), metabolic parameters, and treatment side effects (Udvalg for Kliniske Unders\u00f8gelser Side Effect Rating Scale [UKU scale]) \u2013 were examined using multivariate regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933825100989_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BZ use was significantly associated with lower QoL scores on physical and mental health domains of the SF-36 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), increased impairment across EQ-5D dimensions, and reduced subjective well-being (SQoL-18,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.043). BZ users also presented higher rates of obesity, diabetes, and metabolic syndrome (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Furthermore, BZ use was independently associated with a higher burden of side effects across UKU subscales, particularly in the psychiatric domain (emotional blunting, anxiety, and depressive symptoms;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933825100989_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that BZ use in severe psychiatric disorders may be linked to a substantial multidimensional health burden, including reduced QoL, greater side effect profile, and increased metabolic risk. These results highlight the need for evaluation of long-term BZ use and the promotion of safer alternative treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2025.10098","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:02:16Z","timestamp":1756872136000},"source":"Crossref","is-referenced-by-count":3,"title":["Benzodiazepine use and multidimensional health burden in severe psychiatric disorders: Impaired quality of life, metabolic comorbidities, and adverse effects in a large cross-sectional study"],"prefix":"10.1192","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3743-8960","authenticated-orcid":false,"given":"Vincent","family":"Achour","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"publisher"}],"name":"Sainte Marguerite University Hospital, Assistance Publique des H\u00f4pitaux de Marseille"},{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Aix-Marseille University, UR3279: Health Service Research and Quality of Life Center \u2013 CEReSS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5567-8650","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Faugere","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"publisher"}],"name":"Sainte Marguerite University Hospital, Assistance Publique des H\u00f4pitaux de Marseille"},{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Aix-Marseille University, UR3279: Health Service Research and Quality of Life Center \u2013 CEReSS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-2927","authenticated-orcid":false,"given":"Elo\u00efse","family":"Maakaron","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"publisher"}],"name":"Sainte Marguerite University Hospital, Assistance Publique des H\u00f4pitaux de Marseille"},{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Aix-Marseille University, UR3279: Health Service Research and Quality of Life Center \u2013 CEReSS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3998-5775","authenticated-orcid":false,"given":"Jonathan","family":"Gavat","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"publisher"}],"name":"Sainte Marguerite University Hospital, Assistance Publique des H\u00f4pitaux de Marseille"},{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Aix-Marseille University, UR3279: Health Service Research and Quality of Life Center \u2013 CEReSS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Fond","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"publisher"}],"name":"Sainte Marguerite University Hospital, Assistance Publique des H\u00f4pitaux de Marseille"},{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Aix-Marseille University, UR3279: Health Service Research and Quality of Life Center \u2013 CEReSS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Lan\u00e7on","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"publisher"}],"name":"Sainte Marguerite University Hospital, Assistance Publique des H\u00f4pitaux de Marseille"},{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Aix-Marseille University, UR3279: Health Service Research and Quality of Life Center \u2013 CEReSS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6392-9322","authenticated-orcid":false,"given":"Th\u00e9o","family":"Korchia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/002cp4060","id-type":"ROR","asserted-by":"publisher"}],"name":"Sainte Marguerite University Hospital, Assistance Publique des H\u00f4pitaux de Marseille"},{"name":"Assistance Publique des H\u00f4pitaux de Marseille, Aix-Marseille University, UR3279: Health Service Research and Quality of Life Center \u2013 CEReSS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"S0924933825100989_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.03.001"},{"key":"S0924933825100989_r9","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-05929-3"},{"key":"S0924933825100989_r50","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2021.08.263"},{"key":"S0924933825100989_r5","unstructured":"[5] Diagnostic and statistical manual of mental disorders: DSM-5\u2122, 5th ed. 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