{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:42:25Z","timestamp":1789494145436,"version":"build-2803163510"},"reference-count":67,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924933825000021_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Recent stressful life events (SLEs) are an established risk factor for a range of psychiatric disorders. Animal studies have shown evidence of gray matter (GM) reductions associated with stress, and previous work has found similar associations in humans. However longitudinal studies investigating the association between stress and changes in brain structure are limited.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933825000021_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>The current study uses longitudinal data from the UK Biobank and comprises 4,543 participants with structural neuroimaging and recent SLE data (mean age\u00a0=\u00a061.5\u00a0years). We analyzed the association between recent SLEs and changes in brain structure, determined using the longitudinal FreeSurfer pipeline, focusing on total GM volume and five a priori brain regions: the hippocampus, amygdala, anterior cingulate cortex, orbitofrontal cortex, and insula. We also examined if depression and childhood adversity moderated the relationship between SLEs and brain structure.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933825000021_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Individuals who had experienced recent SLEs exhibited a slower rate of hippocampal decrease over time compared to individuals who did not report any SLEs. Individuals with depression exhibited smaller GM volumes when exposed to recent SLEs. There was no effect of childhood adversity on the relationship between SLEs and brain structure.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924933825000021_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Our findings suggest recent SLEs are not directly associated with an accelerated decline in brain volumes in a population sample of older adults, but instead may alter brain structure via affective disorder psychopathology. Further work is needed to investigate the effects of stress in younger populations who may be more vulnerable to stress-induced changes, and may yet pinpoint brain regions linked to stress-related disorders.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2025.2","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:35:25Z","timestamp":1737430525000},"source":"Crossref","is-referenced-by-count":5,"title":["The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study"],"prefix":"10.1192","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-5495","authenticated-orcid":false,"given":"Cheryl R.Z.","family":"See","sequence":"first","affiliation":[{"name":"King\u2019s College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-0301","authenticated-orcid":false,"given":"Annabel X.","family":"Tan","sequence":"additional","affiliation":[{"name":"Stanford University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-8464","authenticated-orcid":false,"given":"Lucia R.","family":"Valmaggia","sequence":"additional","affiliation":[{"name":"University of Melbourne"},{"name":"King\u2019s College London"},{"name":"KU Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-9947","authenticated-orcid":false,"given":"Matthew J.","family":"Kempton","sequence":"additional","affiliation":[{"name":"King\u2019s College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"S0924933825000021_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"S0924933825000021_r62","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.69"},{"key":"S0924933825000021_r43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117002"},{"key":"S0924933825000021_r33","volume-title":"Health and deprivation: inequality and the north","author":"Townsend","year":"1988"},{"key":"S0924933825000021_r58","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2021.111353"},{"key":"S0924933825000021_r9","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3138"},{"key":"S0924933825000021_r65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2013.01.005"},{"key":"S0924933825000021_r29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.010"},{"key":"S0924933825000021_r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.084"},{"key":"S0924933825000021_r64","doi-asserted-by":"publisher","DOI":"10.1521\/ijct.2010.3.4.380"},{"key":"S0924933825000021_r59","doi-asserted-by":"publisher","DOI":"10.1159\/000501024"},{"key":"S0924933825000021_r1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010418-102857"},{"key":"S0924933825000021_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.084"},{"key":"S0924933825000021_r22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"S0924933825000021_r28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.10.045"},{"key":"S0924933825000021_r60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.01.221"},{"key":"S0924933825000021_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.08.050"},{"key":"S0924933825000021_r31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.06.019"},{"key":"S0924933825000021_r6","doi-asserted-by":"publisher","DOI":"10.1177\/070674370905400104"},{"key":"S0924933825000021_r19","first-page":"697","article-title":"Increasing deactivation of limbic structures over psychosocial stress exposure time","volume":"5","author":"Henze","year":"2020","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging."},{"key":"S0924933825000021_r49","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120079"},{"key":"S0924933825000021_r18","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000276"},{"key":"S0924933825000021_r40","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2020.104926"},{"key":"S0924933825000021_r41","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717001064"},{"key":"S0924933825000021_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.11.022"},{"key":"S0924933825000021_r47","first-page":"133","article-title":"A personalized 12-week \u201cBrain Fitness Program\u201d for improving cognitive function and increasing the volume of hippocampus in elderly with mild cognitive impairment","volume":"3","author":"Fotuhi","year":"2016","journal-title":"J Prev Alzheimers Dis."},{"key":"S0924933825000021_r46","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.27"},{"key":"S0924933825000021_r48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.050"},{"key":"S0924933825000021_r54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.02.008"},{"key":"S0924933825000021_r11","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsv137"},{"key":"S0924933825000021_r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.02.016"},{"key":"S0924933825000021_r5","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328332bb09"},{"key":"S0924933825000021_r14","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2010.522279"},{"key":"S0924933825000021_r7","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.171"},{"key":"S0924933825000021_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2022.100447"},{"key":"S0924933825000021_r52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28735-5"},{"key":"S0924933825000021_r67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1990.tb01360.x"},{"key":"S0924933825000021_r2","article-title":"Neurobiological and systemic effects of chronic stress","volume":"1","author":"McEwen","year":"2017","journal-title":"Chron Stress (Thousand Oaks)"},{"key":"S0924933825000021_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118751"},{"key":"S0924933825000021_r15","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25869"},{"key":"S0924933825000021_r37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1614.2002.01007.x"},{"key":"S0924933825000021_r35","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.19394"},{"key":"S0924933825000021_r30","first-page":"613","article-title":"An ultra-brief screening scale for anxiety and depression: the PHQ\u20134","volume":"50","author":"Kroenke","year":"2009","journal-title":"Psychosomatics."},{"key":"S0924933825000021_r32","first-page":"109","article-title":"A brief instrument for the assessment of childhood abuse and neglect: the childhood trauma screener (CTS)","volume":"39","author":"Grabe","year":"2012","journal-title":"Psychiatr Prax."},{"key":"S0924933825000021_r57","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw154"},{"key":"S0924933825000021_r23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15948-9"},{"key":"S0924933825000021_r63","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19050560"},{"key":"S0924933825000021_r66","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770070110"},{"key":"S0924933825000021_r24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.034"},{"key":"S0924933825000021_r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102683"},{"key":"S0924933825000021_r53","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01161-7"},{"key":"S0924933825000021_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.02.044"},{"key":"S0924933825000021_r3","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8365-7"},{"key":"S0924933825000021_r51","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03144-x"},{"key":"S0924933825000021_r50","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3589271"},{"key":"S0924933825000021_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.044"},{"key":"S0924933825000021_r20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2018.06.002"},{"key":"S0924933825000021_r38","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721002087"},{"key":"S0924933825000021_r8","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(97)00031-8"},{"key":"S0924933825000021_r44","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4564"},{"key":"S0924933825000021_r34","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"S0924933825000021_r56","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2016.1225006"},{"key":"S0924933825000021_r55","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714002293"},{"key":"S0924933825000021_r42","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2005.01.016"},{"key":"S0924933825000021_r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.05.036"},{"key":"S0924933825000021_r61","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.10.1156"},{"key":"S0924933825000021_r36","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.117.1.206"}],"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933825000021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:39:29Z","timestamp":1759847969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933825000021\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0924933825000021"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2025.2","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e18"}}