{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:04:32Z","timestamp":1789383872518,"version":"build-2803163510"},"reference-count":0,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"unspecified","delay-in-days":223,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. Psychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933826122500_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pharmacotherapies have shown limited efficacy in cannabis use disorder (CUD). This exploratory study examined the real-world effectiveness of commonly used psychiatric medications in reducing the risk of substance use and psychiatric hospitalisations among individuals with CUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933826122500_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide prospective cohort study using Swedish health and administrative registers. The cohort included 51,947 individuals aged 16\u201364\u00a0years with a first CUD diagnosis (ICD-10\u00a0F12) between 2006 and 2021. Medication use was modelled as time-dependent with the PRE2DUP method. Within-individual Cox regression was used to compare hospitalisation risk during medication use versus non-use. The primary outcome was hospitalisation for substance use disorder (SUD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933826122500_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ADHD (aHR: 0.85; 95% CI: 0.81\u20130.88) and SUD medications (aHR: 0.97; 0.93\u20130.99) were associated with reduced SUD hospitalisation risk. In contrast, antipsychotics (aHR: 1.12; 1.09\u20131.15), antidepressants (aHR: 1.09; 1.06\u20131.11), and benzodiazepines (aHR: 1.14; 1.11\u20131.17) were associated with increased risk, while mood stabilisers showed no significant effect. Specific agents, including clozapine (aHR: 0.47; 0.31\u20130.73), naltrexone (aHR: 0.79; 0.71\u20130.88), buprenorphine (aHR: 0.92; 0.88\u20130.96), lisdexamfetamine (aHR: 0.74; 0.69\u20130.79), methylphenidate (aHR: 0.90; 0.86\u20130.94), and ADHD polytherapy (aHR: 0.85; 0.75\u20130.96), were associated with reduced risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933826122500_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most psychiatric medications were not associated with a reduced risk of SUD in individuals diagnosed with CUD. However, pharmacotherapies for ADHD, opioid or alcohol use disorder, and treatment-resistant schizophrenia were linked to better outcomes, likely reflecting the underlying clinical trajectories of other comorbid psychiatric disorders rather than direct therapeutic effects on CUD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2026.12250","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:30:51Z","timestamp":1786523451000},"source":"Crossref","is-referenced-by-count":0,"title":["Real-world effectiveness of psychiatric pharmacotherapies in reducing the risk of substance use- and psychiatric hospitalisations in cannabis use disorder \u2013 An exploratory nationwide register-based study"],"prefix":"10.1192","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-2122","authenticated-orcid":false,"given":"Antti","family":"Mustonen","sequence":"first","affiliation":[{"name":"Tampere University"},{"name":"Karolinska Institutet"},{"name":"Sein\u00e4joki Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-9161","authenticated-orcid":false,"given":"Solja","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"University of Turku"},{"name":"Turku University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7244-145X","authenticated-orcid":false,"given":"Markku","family":"L\u00e4hteenvuo","sequence":"additional","affiliation":[{"name":"University of Eastern Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Denissoff","sequence":"additional","affiliation":[{"name":"University of Turku"},{"name":"Turku University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-3126","authenticated-orcid":false,"given":"Antti","family":"Tanskanen","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"},{"name":"University of Eastern Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellenor","family":"Mittendorfer-Rutz","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-6798","authenticated-orcid":false,"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"},{"name":"University of Eastern Finland"},{"name":"University of Helsinki"},{"name":"Center for Psychiatry Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-934X","authenticated-orcid":false,"given":"Heidi","family":"Taipale","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"},{"name":"University of Eastern Finland"},{"name":"Center for Psychiatry Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2026,8,12]]},"container-title":["European Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924933826122500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:21:59Z","timestamp":1789381319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924933826122500\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S0924933826122500"],"URL":"https:\/\/doi.org\/10.1192\/j.eurpsy.2026.12250","relation":{},"ISSN":["0924-9338","1778-3585"],"issn-type":[{"value":"0924-9338","type":"print"},{"value":"1778-3585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e89"}}