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Psychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924933826122603_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Major psychiatric disorders (MPDs) and premenstrual disorders (PMDs) are often comorbid, with indications of shared genetic architecture. However, the specific genetic variants underlying this comorbidity remain elusive. The aim of this study was to identify genomic loci shared between MPDs and PMDs, and to assess the functional characteristics of genes mapped to these loci.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933826122603_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used genome-wide association data for symptoms of PMDs (S-PMD,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a067 068) from the Norwegian Mother, Father and Child Cohort Study (MoBa), and for MPDs (schizophrenia,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0130 644; bipolar disorder,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0827 335; major depression,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01 918 432) from the Psychiatric Genomic Consortium. Shared genetic loci were identified with the conjunctional false discovery rate (conjFDR). Genes mapped to the identified loci were included in functional and pharmacological gene-set enrichment analyses (GSEAs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933826122603_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 20 loci shared between S-PMD and the MPDs, including 19 novel loci for S-PMD (conjFDR&lt;0.05). GSEA revealed genes involved in calcium signaling and neuronal projection pathways. The drug enrichment analysis identified 36 drugs, including riluzole and mianserin, significantly associated with the identified molecular pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924933826122603_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified 20 genetic loci shared between the S-PMD and MPDs, implicating calcium transmission in the pathogenesis of PMDs. Together with the drug enrichment results, this provides a biological basis for repurposing existing drugs in the treatment of PMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/j.eurpsy.2026.12260","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:56:29Z","timestamp":1792047389000},"source":"Crossref","is-referenced-by-count":0,"title":["Shared genetic architecture between premenstrual disorder symptoms and major psychiatric disorders suggests a role for calcium signaling"],"prefix":"10.1192","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-3107","authenticated-orcid":false,"given":"Piotr","family":"Jaholkowski","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7114-6990","authenticated-orcid":false,"given":"Elgeta","family":"Hysaj","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Environmental Medicine, Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Parker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4498-9795","authenticated-orcid":false,"given":"Erik David","family":"Wistr\u00f6m","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3727-4470","authenticated-orcid":false,"given":"Elise M.","family":"Koch","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo"},{"name":"Diakonhjemmet Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-1167","authenticated-orcid":false,"given":"Pravesh","family":"Parekh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo"},{"name":"J. 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