{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:02:06Z","timestamp":1766466126622},"reference-count":29,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":6241,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1194\/jlr.m300093-jlr200","type":"journal-article","created":{"date-parts":[[2003,7,23]],"date-time":"2003-07-23T21:14:17Z","timestamp":1058994857000},"page":"1559-1565","source":"Crossref","is-referenced-by-count":15,"title":["GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release"],"prefix":"10.1016","volume":"44","author":[{"given":"Angela","family":"Bulotta","sequence":"first","affiliation":[]},{"given":"Riccardo","family":"Perfetti","sequence":"additional","affiliation":[]},{"given":"Hongxiang","family":"Hui","sequence":"additional","affiliation":[]},{"given":"L\u00e1szl\u00f3 G.","family":"Boros","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1194\/jlr.M300093-JLR200_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1677\/joe.0.1550369","article-title":"Glucagon-like peptide-1(7\u201336)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies","volume":"155","author":"Dachicourt","year":"1997","journal-title":"J. Endocrinol."},{"key":"10.1194\/jlr.M300093-JLR200_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0303-7207(97)00079-8","article-title":"Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness","volume":"130","author":"Montrose-Rafizadeh","year":"1997","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1194\/jlr.M300093-JLR200_bib3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2337\/diabetes.50.4.785","article-title":"Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells","volume":"50","author":"Hui","year":"2001","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M300093-JLR200_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/(SICI)1097-4652(199912)181:3<470::AID-JCP11>3.0.CO;2-P","article-title":"Glucagon-like peptide-1 does not mediate amylase release from AR42J cells","volume":"181","author":"Zhou","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"10.1194\/jlr.M300093-JLR200_bib5","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1210\/mend.13.8.0321","article-title":"Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells","volume":"13","author":"Salapatek","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1194\/jlr.M300093-JLR200_bib6","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1210\/endo.142.5.8128","article-title":"Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate\/protein kinase A-dependent mechanism","volume":"142","author":"Wang","year":"2001","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M300093-JLR200_bib7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1006\/bbrc.2000.3198","article-title":"Glucagon-like peptide-1 increases glucose-dependent activity of the homeoprotein PDX-1 transactivating domain in pancreatic beta cells","volume":"274","author":"Hussain","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.M300093-JLR200_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nbt0302-243","article-title":"Metabolic control analysis in drug discovery and disease","volume":"20","author":"Cascante","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1194\/jlr.M300093-JLR200_bib9","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1359-6446(02)02179-7","article-title":"Metabolic profiling of cell growth and death in cancer: applications in drug discovery","volume":"7","author":"Boros","year":"2002","journal-title":"Drug Discov. Today."},{"key":"10.1194\/jlr.M300093-JLR200_bib10","first-page":"1183","article-title":"Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells","volume":"60","author":"Boros","year":"2000","journal-title":"Cancer Res."},{"key":"10.1194\/jlr.M300093-JLR200_bib11","doi-asserted-by":"crossref","first-page":"37747","DOI":"10.1074\/jbc.M105796200","article-title":"Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells","volume":"276","author":"Boren","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M300093-JLR200_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00006676-200108000-00004","article-title":"Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells","volume":"23","author":"Boros","year":"2001","journal-title":"Pancreas."},{"key":"10.1194\/jlr.M300093-JLR200_bib13","doi-asserted-by":"crossref","first-page":"46408","DOI":"10.1074\/jbc.M206150200","article-title":"Fermented wheat germ extract inhibits glycolysis\/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells","volume":"277","author":"Comin-Anduix","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M300093-JLR200_bib14","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1046\/j.1365-2036.1996.99271000.x","article-title":"Feasibility of analyzing [13C]urea breath tests for Helicobacter pylori by gas chromatography-mass spectrometry in the selected ion monitoring mode","volume":"10","author":"Kasho","year":"1996","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1194\/jlr.M300093-JLR200_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/abio.2001.5375","article-title":"Advances in the stable isotope-mass spectrometric measurement of DNA synthesis and cell proliferation","volume":"298","author":"Neese","year":"2001","journal-title":"Anal. Biochem."},{"key":"10.1194\/jlr.M300093-JLR200_bib16","first-page":"E843","article-title":"Mass isotopomer study of the non-oxidative pathways of the pentose cycle with [1,2-13C2]glucose","volume":"274","author":"Lee","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1194\/jlr.M300093-JLR200_bib17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1159\/000111442","article-title":"Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes","volume":"18","author":"Lee","year":"1996","journal-title":"Dev. Neurosci."},{"key":"10.1194\/jlr.M300093-JLR200_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0021-9673(00)99131-3","article-title":"Complete mass spectra of N-TAB esters of amino acids","volume":"141","author":"Leimer","year":"1977","journal-title":"J. Cromatogr."},{"key":"10.1194\/jlr.M300093-JLR200_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4613-1151-5_8","article-title":"Stable isotopes and mass isotopomer study of fatty acid and cholesterol synthesis. A review of the MIDA approach","volume":"399","author":"Lee","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1194\/jlr.M300093-JLR200_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/abio.1998.2660","article-title":"High-performance liquid chromatographic determination of insulin in rat and human plasma","volume":"260","author":"Khaksa","year":"1998","journal-title":"Anal. Biochem."},{"key":"10.1194\/jlr.M300093-JLR200_bib21","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1210\/endo.137.5.8612565","article-title":"The third cytoplasmic domain of the GLP-1[7\u201336 amide] receptor is required for coupling to the adenylyl cyclase system","volume":"137","author":"Takhar","year":"1996","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M300093-JLR200_bib22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0014-5793(87)80294-6","article-title":"Differential kinetics of rat insulin I and II processing in rat islets of Langerhans","volume":"223","author":"Gishizky","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1194\/jlr.M300093-JLR200_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00125-001-0719-z","article-title":"The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men","volume":"45","author":"Agerso","year":"2002","journal-title":"Diabetologia."},{"key":"10.1194\/jlr.M300093-JLR200_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0005-2760(96)00066-5","article-title":"The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation","volume":"1302","author":"Schoonjans","year":"1996","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M300093-JLR200_bib25","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1210\/endo.139.4.5893","article-title":"Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors","volume":"139","author":"Gong","year":"1998","journal-title":"Endocrinology."},{"issue":"Suppl 3","key":"10.1194\/jlr.M300093-JLR200_bib26","doi-asserted-by":"crossref","first-page":"S405","DOI":"10.2337\/diabetes.51.2007.S405","article-title":"Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes","volume":"51","author":"Prentki","year":"2002","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M300093-JLR200_bib27","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.2337\/diabetes.47.12.1904","article-title":"Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes","volume":"47","author":"Zhou","year":"1998","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M300093-JLR200_bib28","first-page":"22","volume":"296","author":"Hashiguchi","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1194\/jlr.M300093-JLR200_bib29","doi-asserted-by":"crossref","first-page":"20929","DOI":"10.1074\/jbc.273.33.20929","article-title":"Fatty acid cycling in human hepatoma cells and the effects of troglitazone","volume":"273","author":"Lee","year":"1998","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520337664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520337664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M300093-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T17:44:45Z","timestamp":1637430285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520337664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S0022227520337664"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m300093-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}