{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:23:17Z","timestamp":1780327397475,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":3790,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1194\/jlr.d002642","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T03:07:12Z","timestamp":1264734432000},"page":"1560-1565","source":"Crossref","is-referenced-by-count":17,"title":["2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles"],"prefix":"10.1016","volume":"51","author":[{"given":"Francisco J.","family":"Blanco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f2nia","family":"Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bancells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammo","family":"Diercks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Ord\u00f3\u00f1ez-Llanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"S\u00e1nchez-Quesada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.D002642_bib1","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.106.676890","article-title":"Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications","volume":"116","author":"Tabas","year":"2007","journal-title":"Circulation."},{"key":"10.1194\/jlr.D002642_bib2","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0022-2275(20)30267-4","article-title":"Structure of apolipoprotein B-100 in low density lipoproteins","volume":"42","author":"Segrest","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D002642_bib3","doi-asserted-by":"crossref","first-page":"53B","DOI":"10.1016\/0002-9149(95)80012-H","article-title":"Dense low density lipoproteins and coronary artery disease","volume":"75","author":"Krauss","year":"1995","journal-title":"Am. J. Cardiol."},{"key":"10.1194\/jlr.D002642_bib4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2143\/AC.59.5.2005219","article-title":"Oxidized LDL and coronary heart disease","volume":"59","author":"Holvoet","year":"2004","journal-title":"Acta Cardiol."},{"key":"10.1194\/jlr.D002642_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00041433-200406000-00014","article-title":"Electronegative low-density lipoprotein","volume":"15","author":"S\u00e1nchez-Quesada","year":"2004","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1194\/jlr.D002642_bib6","doi-asserted-by":"crossref","first-page":"15863","DOI":"10.1021\/bi048825z","article-title":"Impaired binding affinity of electronegative low-density lipoprotein (LDL) to the LDL receptor is related to nonesterified fatty acids and lysophosphatidylcholine content","volume":"43","author":"Ben\u00edtez","year":"2004","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.D002642_bib7","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1021\/bi800537h","article-title":"Novel phospholipolytic activities associated with electronegative low-density lipoprotein are involved in increased self-aggregation","volume":"47","author":"Bancells","year":"2008","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.D002642_bib8","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1529\/biophysj.105.075788","article-title":"Low density lipoprotein aged in plasma forms clusters resembling subendothelial droplets: aggregation via surface sites","volume":"90","author":"De Spirito","year":"2006","journal-title":"Biophys. J."},{"key":"10.1194\/jlr.D002642_bib9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0891-5849(01)00555-X","article-title":"Loss of apoB-100 secondary structure and conformation in hydroperoxide rich, electronegative LDL(\u2013)","volume":"31","author":"Parasassi","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1194\/jlr.D002642_bib10","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1096\/fj.07-097774","article-title":"Low density lipoprotein misfolding and amyloidogenesis","volume":"22","author":"Parasassi","year":"2008","journal-title":"FASEB J."},{"key":"10.1194\/jlr.D002642_bib11","doi-asserted-by":"crossref","first-page":"13831","DOI":"10.1016\/S0021-9258(18)68319-X","article-title":"A 13C NMR characterization of lysine residues in apolipoprotein B and their role in binding to the low density lipoprotein receptor","volume":"263","author":"Lund-Katz","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D002642_bib12","doi-asserted-by":"crossref","first-page":"16842","DOI":"10.1016\/S0021-9258(18)37468-4","article-title":"The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells","volume":"263","author":"Aviram","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D002642_bib13","doi-asserted-by":"crossref","first-page":"12867","DOI":"10.1021\/bi980828m","article-title":"Apolipoprotein B-100 conformation and particle surface charge in human LDL subspecies: implication for LDL receptor interaction","volume":"37","author":"Lund-Katz","year":"1998","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.D002642_bib14","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI103182","article-title":"The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum","volume":"34","author":"Havel","year":"1955","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.D002642_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0021-9150(02)00374-X","article-title":"Electronegative LDL of FH subjects: chemical characterization and induction of chemokine release from human endothelial cells","volume":"166","author":"S\u00e1nchez-Quesada","year":"2003","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.D002642_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00211777","article-title":"1H, 13C and 15N chemical shift referencing in biomolecular NMR","volume":"6","author":"Wishart","year":"1995","journal-title":"J. Biomol. NMR."},{"key":"10.1194\/jlr.D002642_bib17","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1016\/S0021-9258(17)34284-9","article-title":"Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts","volume":"253","author":"Weisgraber","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D002642_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1749-6632.1980.tb21306.x","article-title":"Alterations in metabolic activity of plasma lipoproteins following selective chemical modification of the apoproteins","volume":"348","author":"Mahley","year":"1980","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1194\/jlr.D002642_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.ATV.3.2.149","article-title":"Enhanced macrophage degradation of biologically modified low density lipoprotein","volume":"3","author":"Henriksen","year":"1983","journal-title":"Arteriosclerosis."},{"key":"10.1194\/jlr.D002642_bib20","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2337\/diab.44.9.1093","article-title":"Isolation, characterization, and metabolism of the glycated and nonglycated subfractions of low-density lipoproteins isolated from type I diabetic patients and nondiabetic subjects","volume":"44","author":"Klein","year":"1995","journal-title":"Diabetes."},{"key":"10.1194\/jlr.D002642_bib21","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0022-2275(20)41629-3","article-title":"Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor","volume":"32","author":"Nigon","year":"1991","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D002642_bib22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0022-2275(20)30111-5","article-title":"Density distribution of electronegative LDL in normolipemic and hyperlipemic subjects","volume":"43","author":"S\u00e1nchez-Quesada","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D002642_bib23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1194\/jlr.M500481-JLR200","article-title":"Electronegative LDLs from familial hypercholesterolemic patients are physicochemically heterogeneous but uniformly proapoptotic","volume":"48","author":"Chen","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D002642_bib24","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/01.CIR.0000065220.70220.F7","article-title":"Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription","volume":"107","author":"Chen","year":"2003","journal-title":"Circulation."},{"key":"10.1194\/jlr.D002642_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.clinbiochem.2005.09.014","article-title":"Detection of electronegative low density lipoprotein (LDL-) in plasma and atherosclerotic lesions by monoclonal antibody-based immunoassays","volume":"39","author":"Damasceno","year":"2006","journal-title":"Clin. Biochem."},{"key":"10.1194\/jlr.D002642_bib26","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/01.ATV.16.6.773","article-title":"A cytotoxic electronegative LDL subfraction is present in human plasma","volume":"16","author":"Demuth","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520410314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520410314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.D002642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T22:07:01Z","timestamp":1637446021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520410314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0022227520410314"],"URL":"https:\/\/doi.org\/10.1194\/jlr.d002642","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}