{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:33:40Z","timestamp":1791657220153,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":2443,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1194\/jlr.d040790","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T03:35:35Z","timestamp":1384313735000},"page":"155-162","source":"Crossref","is-referenced-by-count":53,"title":["High-temperature GC-MS-based serum cholesterol signatures may reveal sex differences in vasospastic angina"],"prefix":"10.1016","volume":"55","author":[{"given":"Hyun-Hwa","family":"Son","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Yeon","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Seog","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Chul","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.D040790_bib1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature04399","article-title":"Role of cholesterol and lipid organization in disease","volume":"438","author":"Maxfield","year":"2005","journal-title":"Nature."},{"key":"10.1194\/jlr.D040790_bib2","first-page":"219","article-title":"Harper's Illustrated Biochemistry. 29th edition.","author":"Murray","year":"2012","journal-title":"McGraw-Hill Medical, New York."},{"key":"10.1194\/jlr.D040790_bib3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0022-2275(20)34322-4","article-title":"Role of acyl-CoA:cholesterol acyltransferase in cellular cholesterol metabolism","volume":"26","author":"Suckling","year":"1985","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D040790_bib4","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1016\/S0021-9258(18)83541-4","article-title":"Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins","volume":"264","author":"Francone","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D040790_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2006.12.001","article-title":"Adrenal cholesterol utilization","volume":"265\u2013266","author":"Kraemer","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1194\/jlr.D040790_bib6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1124\/dmd.105.008789","article-title":"Cholesterol-metabolizing cytochromes P450","volume":"34","author":"Pikuleva","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1194\/jlr.D040790_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tem.2011.12.002","article-title":"Oxysterols as non-genomic regulators of cholesterol homeostasis","volume":"23","author":"Bielska","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1194\/jlr.D040790_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.plipres.2008.04.002","article-title":"Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised","volume":"47","author":"Gill","year":"2008","journal-title":"Prog. Lipid Res."},{"key":"10.1194\/jlr.D040790_bib9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.35.5.692","article-title":"Cholesteryl ester synthesis in normal and atherosclerotic aortas of rabbits and rhesus monkeys","volume":"35","author":"Brecher","year":"1974","journal-title":"Circ. Res."},{"key":"10.1194\/jlr.D040790_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(98)00196-8","article-title":"Oxysterols and atherosclerosis","volume":"142","author":"Brown","year":"1999","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.D040790_bib11","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nm1641","article-title":"27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen","volume":"13","author":"Umetani","year":"2007","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.D040790_bib12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/01.ATV.19.4.967","article-title":"Increased plasma 7\u03b2-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease","volume":"19","author":"Zied\u00e9n","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.D040790_bib13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1373\/clinchem.2010.158766","article-title":"Proposed serum cholesterol reference measurement procedure by gas chromatography-isotope dilution mass spectrometry","volume":"57","author":"Edwards","year":"2011","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.D040790_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0022-2275(20)37451-4","volume":"38","author":"Cullen","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D040790_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbalip.2005.12.007","article-title":"High throughput quantification of cholesterol and cholesteryl ester by elecrospray ionization tandem mass spectrometry (ESI-MS\/MS)","volume":"1761","author":"Liebisch","year":"2006","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.D040790_bib16","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1194\/jlr.M600497-JLR200","article-title":"Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols","volume":"48","author":"Karu","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D040790_bib17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1194\/jlr.D800040-JLR200","article-title":"Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS\/MS","volume":"50","author":"Honda","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D040790_bib18","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1373\/clinchem.2012.189605","article-title":"Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors","volume":"58","author":"Matysik","year":"2012","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.D040790_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jchromb.2006.05.024","article-title":"Simulaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM)","volume":"842","author":"Ahmida","year":"2006","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1194\/jlr.D040790_bib20","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jpba.2009.05.037","article-title":"A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bioanalysis by means of HybridSPE","volume":"50","author":"Pucci","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1194\/jlr.D040790_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.microc.2004.02.008","article-title":"Two decades of high temperature gas chromatography (1983\u20132003): what's next?","volume":"77","author":"dos Santos Pereira","year":"2004","journal-title":"Microchem. J."},{"key":"10.1194\/jlr.D040790_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF02277508","article-title":"GC-MS characterization and quantification of sterols and cholesterol oxidation products","volume":"35","author":"Pizzoferrato","year":"1993","journal-title":"Chromatographia."},{"key":"10.1194\/jlr.D040790_bib23","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.chroma.2008.12.059","article-title":"Mass spectrometric profiling of saturated fatty acid esters of steroids separated by high-temperature gas chromatography","volume":"1216","author":"Jung","year":"2009","journal-title":"J. Chromatogr. A."},{"key":"10.1194\/jlr.D040790_bib24","article-title":"Cytochrome P450-mediated metabolic alterations in preeclampsia evaluated by quantitative steroid signatures","author":"Moon","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol. In press"},{"key":"10.1194\/jlr.D040790_bib25","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1194\/jlr.D022285","article-title":"A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma","volume":"53","author":"McDonald","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D040790_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-4347(00)82881-9","article-title":"Studies on anabolic steroids","volume":"489","author":"Mass\u00e9","year":"1989","journal-title":"J. Chromatogr."},{"key":"10.1194\/jlr.D040790_bib27","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cca.2010.02.068","article-title":"Database-dependent metabolite profiling focused on steroid and fatty acid derivatives using high-temperature gas chromatography-mass spectrometry","volume":"411","author":"Jung","year":"2010","journal-title":"Clin. Chim. Acta."},{"key":"10.1194\/jlr.D040790_bib28","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1016\/j.jchromb.2010.10.012","article-title":"Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography\/mass spectrometry","volume":"878","author":"Ismaiel","year":"2010","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1194\/jlr.D040790_bib29","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/rcm.3680","volume":"22","author":"Wu","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1194\/jlr.D040790_bib30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jchromb.2007.09.007","article-title":"Monitoring phospholipids for assessment of matrix effects in a liquid chromatography-tandem mass spectrometry method for hydrocodone and pseudoephedrine in human plasma","volume":"859","author":"Ismaiel","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1194\/jlr.D040790_bib31","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s11883-005-0065-6","article-title":"Gender differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular disease","volume":"7","author":"Knopp","year":"2005","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1194\/jlr.D040790_bib32","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/01.CIR.99.9.1165","article-title":"Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland","volume":"99","author":"Jousilahti","year":"1999","journal-title":"Circulation."},{"key":"10.1194\/jlr.D040790_bib33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/01.CIR.93.3.450","article-title":"Smoking, serum lipids, blood pressure, and sex differences in myocardial infarction: a 12-year follow-up of the Finnmark Study","volume":"93","author":"Nj\u00f8lstad","year":"1996","journal-title":"Circulation."},{"key":"10.1194\/jlr.D040790_bib34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/oxfordjournals.aje.a115483","article-title":"High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the lipid research clinics prevalence study","volume":"131","author":"Jacobs","year":"1990","journal-title":"Am. J. Epidemiol."},{"key":"10.1194\/jlr.D040790_bib35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cell.2012.06.054","article-title":"Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses","volume":"151","author":"Spann","year":"2012","journal-title":"Cell."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752031751X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752031751X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.D040790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T16:06:25Z","timestamp":1637424385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002222752031751X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S002222752031751X"],"URL":"https:\/\/doi.org\/10.1194\/jlr.d040790","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}