{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:33:34Z","timestamp":1791657214897,"version":"4.3.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":1959,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1194\/jlr.d058487","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:01:32Z","timestamp":1428883292000},"page":"1222-1233","source":"Crossref","is-referenced-by-count":71,"title":["A validated LC-MS\/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid"],"prefix":"10.1016","volume":"56","author":[{"given":"Rohini","family":"Sidhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Y.","family":"Farhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Carrillo-Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra","family":"Woolery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ottinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forbes D.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean E.","family":"Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Ory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuntian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.D058487_bib1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00041433-200104000-00003","article-title":"Cholesterol metabolism in the brain","volume":"12","author":"Dietschy","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1194\/jlr.D058487_bib2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","article-title":"Brain cholesterol: long secret life behind a barrier","volume":"24","author":"Bj\u00f6rkhem","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.D058487_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell."},{"key":"10.1194\/jlr.D058487_bib4","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1073\/pnas.96.13.7238","article-title":"cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain","volume":"96","author":"Lund","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.D058487_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2012.01.017","article-title":"Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms","volume":"510","author":"Besga","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D058487_bib6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0022-2275(20)32393-2","article-title":"Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface","volume":"41","author":"Bretillon","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(00)01466-X","article-title":"Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases","volume":"293","author":"Bretillon","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D058487_bib8","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.clineuro.2005.07.010","article-title":"Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis","volume":"108","author":"Karrenbauer","year":"2006","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1194\/jlr.D058487_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neulet.2004.07.031","article-title":"Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients","volume":"368","author":"K\u00f6lsch","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D058487_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neulet.2011.03.025","article-title":"Whole body cholesterol metabolism is impaired in Huntington's disease","volume":"494","author":"Leoni","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D058487_bib11","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1093\/brain\/awn212","article-title":"Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease","volume":"131","author":"Leoni","year":"2008","journal-title":"Brain."},{"key":"10.1194\/jlr.D058487_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(02)00887-X","article-title":"Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis","volume":"331","author":"Leoni","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D058487_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2008.07.047","article-title":"CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk","volume":"1232","author":"Qureischie","year":"2008","journal-title":"Brain Res."},{"key":"10.1194\/jlr.D058487_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2009.06.073","article-title":"Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease","volume":"462","author":"Solomon","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D058487_bib15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3940(03)00667-0","article-title":"Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients","volume":"347","author":"Teunissen","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D058487_bib16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0197-4580(03)00005-8","article-title":"Combination of serum markers related to several mechanisms in Alzheimer's disease","volume":"24","author":"Teunissen","year":"2003","journal-title":"Neurobiol. Aging."},{"key":"10.1194\/jlr.D058487_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2377-11-121","article-title":"Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study","volume":"11","author":"Zuliani","year":"2011","journal-title":"BMC Neurol."},{"key":"10.1194\/jlr.D058487_bib18","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3233\/JAD-2012-121585","article-title":"Brain cholesterol metabolism, oxysterols, and dementia","volume":"33","author":"Hughes","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1194\/jlr.D058487_bib19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bcp.2013.03.015","article-title":"Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid","volume":"86","author":"Leoni","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1194\/jlr.D058487_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/abio.1995.1110","article-title":"Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry","volume":"225","author":"Dzeletovic","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1194\/jlr.D058487_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ab.2010.09.031","article-title":"Gas chromatography-mass spectrometry-based simultaneous quantitative analytical method for urinary oxysterols and bile acids in rats","volume":"408","author":"Kumar","year":"2011","journal-title":"Anal. Biochem."},{"key":"10.1194\/jlr.D058487_bib22","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1373\/clinchem.2012.189605","article-title":"Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors","volume":"58","author":"Matysik","year":"2012","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.D058487_bib23","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1194\/jlr.D300036-JLR200","article-title":"Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry","volume":"45","author":"Burkard","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s11745-006-5010-0","article-title":"HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs","volume":"41","author":"Mazalli","year":"2006","journal-title":"Lipids."},{"key":"10.1194\/jlr.D058487_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ab.2008.05.037","article-title":"Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol","volume":"381","author":"DeBarber","year":"2008","journal-title":"Anal. Biochem."},{"key":"10.1194\/jlr.D058487_bib26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.chroma.2014.08.088","article-title":"Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry","volume":"1364","author":"Ahonen","year":"2014","journal-title":"J. Chromatogr. A."},{"key":"10.1194\/jlr.D058487_bib27","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1194\/jlr.D022285","article-title":"A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma","volume":"53","author":"McDonald","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12868-014-0137-z","article-title":"Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum","volume":"15","author":"Bandaru","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1194\/jlr.D058487_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jasms.2005.10.012","article-title":"Analysis of oxysterols by electrospray tandem mass spectrometry","volume":"17","author":"Griffiths","year":"2006","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1194\/jlr.D058487_bib30","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1021\/pr8001639","article-title":"Discovering oxysterols in plasma: a window on the metabolome","volume":"7","author":"Griffiths","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1194\/jlr.D058487_bib31","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1194\/jlr.M600497-JLR200","article-title":"Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols","volume":"48","author":"Karu","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib32","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1194\/jlr.D028233","article-title":"Analysis of bioactive oxysterols in newborn mouse brain by LC\/MS","volume":"53","author":"Meljon","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib33","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1194\/jlr.D048801","article-title":"Highly automated nano-LC\/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols","volume":"55","author":"Roberg-Larsen","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/rcm.2820","article-title":"Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine","volume":"21","author":"Jiang","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1194\/jlr.D058487_bib35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1194\/jlr.D800040-JLR200","article-title":"Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS\/MS","volume":"50","author":"Honda","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib36","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1007\/s00216-012-6396-6","article-title":"Development of a novel method for quantification of sterols and oxysterols by UPLC-ESI-HRMS: application to a neuroinflammation rat model","volume":"404","author":"Ayciriex","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1194\/jlr.D058487_bib37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1515\/CCLM.2004.034","article-title":"Diagnostic use of cerebral and extracerebral oxysterols","volume":"42","author":"Leoni","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1194\/jlr.D058487_bib38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2174\/1568026613666131127160118","article-title":"Collaborative development of 2-hydroxypropyl-beta-cyclodextrin for the treatment of Niemann-Pick type C1 disease","volume":"14","author":"Ottinger","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1194\/jlr.D058487_bib39","article-title":"US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, and Center for Veterinary Medicine","year":"2001","journal-title":"Guidance for Industry: Bioanalytical Method Validations. Accessed April 7, 2015, at http:\/\/www.fda.gov\/downloads\/Drugs\/Guidances\/ucm070107.pdf."},{"key":"10.1194\/jlr.D058487_bib40","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11095-010-0363-8","article-title":"Assessment of pharmacologic area under the curve when baselines are variable","volume":"28","author":"Scheff","year":"2011","journal-title":"Pharm. Res."},{"key":"10.1194\/jlr.D058487_bib41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/bmc.1373","article-title":"Systematic LC-MS\/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography","volume":"24","author":"Jemal","year":"2010","journal-title":"Biomed. Chromatogr."},{"key":"10.1194\/jlr.D058487_bib42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.4155\/bio.10.1","article-title":"Evaluation of the relationship between a pharmaceutical compound's distribution coefficient, log D and adsorption loss to polypropylene in urine and CSF","volume":"2","author":"Kadar","year":"2010","journal-title":"Bioanalysis."},{"key":"10.1194\/jlr.D058487_bib43","article-title":"Advanced Chemistry Development (ACD\/Labs) software V11.02, \u00a9 1994\u20132014 ACD\/Labs.","author":"Scifinder.","year":"2015","journal-title":"Accessed April 7, 2015 at http:\/\/www.cas.org\/products\/scifinder."},{"key":"10.1194\/jlr.D058487_bib44","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4155\/bio.10.114","article-title":"Challenges in urine bioanalytical assays: overcoming nonspecific binding","volume":"2","author":"Ji","year":"2010","journal-title":"Bioanalysis."},{"key":"10.1194\/jlr.D058487_bib45","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1007\/s11095-007-9291-7","article-title":"Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays","volume":"24","author":"Viswanathan","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1194\/jlr.D058487_bib46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.clinbiochem.2004.12.003","article-title":"Assessing analytical specificity in quantitative analysis using tandem mass spectrometry","volume":"38","author":"Kushnir","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1194\/jlr.D058487_bib47","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/rcm.3959","article-title":"Are liquid chromatography\/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria?","volume":"23","author":"Kaufmann","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1194\/jlr.D058487_bib48","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1373\/clinchem.2009.138602","article-title":"Pitfalls associated with the use of liquid chromatography-tandem mass spectrometry in the clinical laboratory","volume":"56","author":"Vogeser","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.D058487_bib49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1399-0004.2003.00147.x","article-title":"Niemann-Pick disease type C","volume":"64","author":"Vanier","year":"2003","journal-title":"Clin. Genet."},{"key":"10.1194\/jlr.D058487_bib50","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1194\/jlr.M700525-JLR200","article-title":"Genetic variations and treatments that affect the lifespan of the NPC1 mouse","volume":"49","author":"Liu","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib51","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1073\/pnas.0810895106","article-title":"Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-\/- mouse","volume":"106","author":"Liu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.D058487_bib52","doi-asserted-by":"crossref","first-page":"e6951","DOI":"10.1371\/journal.pone.0006951","article-title":"Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression","volume":"4","author":"Davidson","year":"2009","journal-title":"PLoS ONE."},{"key":"10.1194\/jlr.D058487_bib53","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.1093\/hmg\/ddu331","article-title":"Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1)","volume":"23","author":"Tortelli","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.D058487_bib54","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1194\/jlr.D050278","article-title":"Development and validation of sensitive LC-MS\/MS assays for quantification of HP-beta-CD in human plasma and CSF","volume":"55","author":"Jiang","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D058487_bib55","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11095-005-9045-3","article-title":"Fit-for-purpose method development and validation for successful biomarker measurement","volume":"23","author":"Lee","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1194\/jlr.D058487_bib56","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s11095-005-2495-9","article-title":"Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report","volume":"22","author":"Lee","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1194\/jlr.D058487_bib57","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/jssc.200600202","article-title":"Column selectivity for two-dimensional liquid chromatography","volume":"29","author":"Jandera","year":"2006","journal-title":"J. Sep. Sci."},{"key":"10.1194\/jlr.D058487_bib58","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chroma.2007.08.054","article-title":"Fast, comprehensive two-dimensional liquid chromatography","volume":"1168","author":"Stoll","year":"2007","journal-title":"J. Chromatogr. A."},{"key":"10.1194\/jlr.D058487_bib59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.aca.2009.03.041","article-title":"Comprehensive liquid chromatography: fundamental aspects and practical considerations\u2013a review","volume":"641","author":"Fran\u00e7ois","year":"2009","journal-title":"Anal. Chim. Acta."},{"key":"10.1194\/jlr.D058487_bib60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1586\/14789450.1.1.37","article-title":"2D-LC\/MS techniques for the identification of proteins in highly complex mixtures","volume":"1","author":"N\u00e4gele","year":"2004","journal-title":"Expert Rev. Proteomics."},{"key":"10.1194\/jlr.D058487_bib61","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jchromb.2009.02.050","article-title":"Highly efficient peptide separations in proteomics. Part 2: bi- and multidimensional liquid-based separation techniques","volume":"877","author":"Sandra","year":"2009","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1194\/jlr.D058487_bib62","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00216-010-3659-y","article-title":"Recent progress in online, comprehensive two-dimensional high-performance liquid chromatography for non-proteomic applications","volume":"397","author":"Stoll","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1194\/jlr.D058487_bib63","first-page":"39","article-title":"Two-dimensional HPLC in pharmaceutical analysis","volume":"16","author":"Zhang","year":"2013","journal-title":"Am. Pharm. Rev."},{"key":"10.1194\/jlr.D058487_bib64","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00216-010-4327-y","article-title":"Recent advances of chromatography and mass spectrometry in lipidomics","volume":"399","author":"Li","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1194\/jlr.D058487_bib65","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1074\/jbc.M113.526392","article-title":"Plasma signature of neurological disease in the monogenetic disorder Niemann-Pick Type C","volume":"289","author":"Alam","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D058487_bib66","article-title":"Product manual, 24(S)-Hydroxycholesterol ELISA Kit.","author":"Enzo Life Sciences","year":"2015","journal-title":"Accessed April 7, 2015 at http:\/\/static.enzolifesciences.com\/fileadmin\/files\/manual\/ADI-900-210_insert.pdf."},{"key":"10.1194\/jlr.D058487_bib67","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/genetics\/73.2.303","article-title":"Inheritance of plasma cholesterol levels in mice","volume":"73","author":"Weibust","year":"1973","journal-title":"Genetics."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520317326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520317326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.D058487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T16:05:21Z","timestamp":1637424321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520317326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0022227520317326"],"URL":"https:\/\/doi.org\/10.1194\/jlr.d058487","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}