{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:28:46Z","timestamp":1788884926667,"version":"build-2803163510"},"reference-count":76,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":561,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["1008787"],"award-info":[{"award-number":["1008787"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008956","name":"Department of Food Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["482597"],"award-info":[{"award-number":["482597"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES002710"],"award-info":[{"award-number":["R01 ES002710"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES004699"],"award-info":[{"award-number":["P42 ES004699"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1194\/jlr.d084228","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T09:43:45Z","timestamp":1542879825000},"page":"671-682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Brain oxylipin concentrations following hypercapnia\/ischemia: effects of brain dissection and dissection time"],"prefix":"10.1016","volume":"60","author":[{"given":"Marie","family":"Hennebelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam H.","family":"Metherel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P.","family":"Kitson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurika","family":"Otoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Sing Stephen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Bazinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer Y.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.D084228_bib1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1042\/bj0440494","article-title":"Concentration of lipids in the brain of infants and adults","volume":"44","author":"Johnson","year":"1949","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.D084228_bib2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-2275(20)39619-X","article-title":"Lipid composition of the normal human brain: gray matter, white matter, and myelin","volume":"6","author":"O'Brien","year":"1965","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D084228_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11064-009-0087-5","article-title":"Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease","volume":"35","author":"Fraser","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1194\/jlr.D084228_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.plefa.2006.07.010","article-title":"Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology","volume":"75","author":"McNamara","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids."},{"key":"10.1194\/jlr.D084228_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.plefa.2012.07.006","article-title":"Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats","volume":"87","author":"Taha","year":"2012","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids."},{"key":"10.1194\/jlr.D084228_bib6","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1194\/jlr.D084228_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MCO.0000000000000141","article-title":"Omega-3 polyunsaturated fatty acids and brain aging","volume":"18","author":"Denis","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"10.1194\/jlr.D084228_bib8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1179\/1476830511Y.0000000012","article-title":"Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: a review","volume":"14","author":"Karr","year":"2011","journal-title":"Nutr. Neurosci."},{"key":"10.1194\/jlr.D084228_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejphar.2015.05.045","article-title":"N-3 polyunsaturated fatty acids in animal models with neuroinflammation: an update","volume":"785","author":"Tr\u00e9panier","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1194\/jlr.D084228_bib10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3945\/an.114.007732","article-title":"Advances in our understanding of oxylipins derived from dietary PUFAs","volume":"6","author":"Gabbs","year":"2015","journal-title":"Adv. Nutr."},{"key":"10.1194\/jlr.D084228_bib11","doi-asserted-by":"crossref","first-page":"19330","DOI":"10.1074\/jbc.270.33.19330","article-title":"Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E\/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid","volume":"270","author":"Laneuville","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D084228_bib12","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science."},{"key":"10.1194\/jlr.D084228_bib13","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.18632\/oncotarget.2994","article-title":"12\/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models","volume":"6","author":"Chang","year":"2015","journal-title":"Oncotarget."},{"key":"10.1194\/jlr.D084228_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/01.RES.76.3.457","article-title":"Role of lipoxygenase metabolites in ischemic preconditioning","volume":"76","author":"Murphy","year":"1995","journal-title":"Circ. Res."},{"key":"10.1194\/jlr.D084228_bib15","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1194\/jlr.M800199-JLR200","article-title":"Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism","volume":"49","author":"Fer","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D084228_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.abb.2008.01.002","article-title":"Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450","volume":"471","author":"Fer","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1194\/jlr.D084228_bib17","doi-asserted-by":"crossref","first-page":"32720","DOI":"10.1074\/jbc.M110.118406","article-title":"Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids","volume":"285","author":"Arnold","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D084228_bib18","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1074\/jbc.M114.635151","article-title":"15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy omega-3 fatty acids","volume":"290","author":"Wendell","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D084228_bib19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cbi.2014.10.029","article-title":"15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways","volume":"234","author":"Snyder","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1194\/jlr.D084228_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1021\/tx990162c","article-title":"Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase","volume":"13","author":"Greene","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1194\/jlr.D084228_bib21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.prostaglandins.2006.05.004","article-title":"Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)","volume":"82","author":"Inceoglu","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1194\/jlr.D084228_bib22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/cne.903550208","article-title":"Characterization of inducible cyclooxygenase in rat brain","volume":"355","author":"Breder","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1194\/jlr.D084228_bib23","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1161\/01.STR.0000249004.25444.a5","article-title":"Baicalein and 12\/15-lipoxygenase in the ischemic brain","volume":"37","author":"van Leyen","year":"2006","journal-title":"Stroke."},{"key":"10.1194\/jlr.D084228_bib24","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.neurobiolaging.2006.06.007","article-title":"The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old","volume":"28","author":"Chinnici","year":"2007","journal-title":"Neurobiol. Aging."},{"key":"10.1194\/jlr.D084228_bib25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2011.07.058","article-title":"Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain","volume":"194","author":"Sarkar","year":"2011","journal-title":"Neuroscience."},{"key":"10.1194\/jlr.D084228_bib26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1369\/jhc.2008.950659","article-title":"Distribution and expression of soluble epoxide hydrolase in human brain","volume":"56","author":"Sura","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"10.1194\/jlr.D084228_bib27","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1152\/jn.00696.2004","article-title":"Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons","volume":"93","author":"Chen","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1194\/jlr.D084228_bib28","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1523\/JNEUROSCI.2392-05.2005","article-title":"Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor","volume":"25","author":"Sang","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1194\/jlr.D084228_bib29","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1038\/s41598-017-02914-7","article-title":"Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission","volume":"7","author":"Hennebelle","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1194\/jlr.D084228_bib30","first-page":"H1171","article-title":"Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid","volume":"259","author":"Ellis","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1194\/jlr.D084228_bib31","first-page":"H519","article-title":"Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle","volume":"263","author":"Gebremedhin","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1194\/jlr.D084228_bib32","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/01616412.2017.1321710","article-title":"The 15-LO-1\/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains","volume":"39","author":"Chen","year":"2017","journal-title":"Neurol. Res."},{"key":"10.1194\/jlr.D084228_bib33","first-page":"632","article-title":"Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures","volume":"117","author":"Abdu","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.D084228_bib34","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0306-4522(00)00347-X","article-title":"Prostaglandin E(2) enhances axonal transport and neuritogenesis in cultured mouse dorsal root ganglion neurons","volume":"100","author":"Hiruma","year":"2000","journal-title":"Neuroscience."},{"key":"10.1194\/jlr.D084228_bib35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/jnc.12392","article-title":"Unesterified docosahexaenoic acid is protective in neuroinflammation","volume":"127","author":"Orr","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.D084228_bib36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12031-015-0670-y","article-title":"Epoxyeicosanoid signaling provides multi-target protective effects on neurovascular unit in rats after focal ischemia","volume":"58","author":"Liu","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1194\/jlr.D084228_bib37","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1161\/01.STR.0000016332.37292.59","article-title":"Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack","volume":"33","author":"Alkayed","year":"2002","journal-title":"Stroke."},{"key":"10.1194\/jlr.D084228_bib38","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1161\/STROKEAHA.107.508325","article-title":"Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia","volume":"39","author":"Zhang","year":"2008","journal-title":"Stroke."},{"key":"10.1194\/jlr.D084228_bib39","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/nan.12291","article-title":"14,15-Epoxyeicosatrienoic acid promotes production of BDNF from astrocytes and exerts neuroprotective effects during ischemic injury","volume":"42","author":"Yuan","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1194\/jlr.D084228_bib40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1096\/fj.03-0837com","article-title":"A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation","volume":"18","author":"Gilroy","year":"2004","journal-title":"FASEB J."},{"key":"10.1194\/jlr.D084228_bib41","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1023\/A:1022030306359","article-title":"Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation","volume":"22","author":"Deutsch","year":"1997","journal-title":"Neurochem. Res."},{"key":"10.1194\/jlr.D084228_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2760(70)90086-X","article-title":"Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain","volume":"218","author":"Baz\u00e1n","year":"1970","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.D084228_bib43","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1471-4159.1998.70010325.x","article-title":"Selective acceleration of arachidonic acid reincorporation into brain membrane phospholipid following transient ischemia in awake gerbil","volume":"70","author":"Rabin","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.D084228_bib44","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.expneurol.2012.04.007","article-title":"Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke","volume":"236","author":"Bazan","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1194\/jlr.D084228_bib45","doi-asserted-by":"crossref","first-page":"43807","DOI":"10.1074\/jbc.M305841200","article-title":"Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression","volume":"278","author":"Marcheselli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.D084228_bib46","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbrc.2014.06.022","article-title":"14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen\/glucose deprivation-induced apoptosis","volume":"450","author":"Wang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.D084228_bib47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm1362","article-title":"Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity","volume":"12","author":"Kawano","year":"2006","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.D084228_bib48","doi-asserted-by":"crossref","first-page":"17956","DOI":"10.1038\/srep17956","article-title":"Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke","volume":"5","author":"Frankowski","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1194\/jlr.D084228_bib49","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1745-7254.2007.00578.x","article-title":"Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats","volume":"28","author":"Chu","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1194\/jlr.D084228_bib50","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1023\/A:1020916905312","article-title":"Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils","volume":"24","author":"Rao","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1194\/jlr.D084228_bib51","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.cell.2010.11.033","article-title":"Lipidomics: new tools and applications","volume":"143","author":"Wenk","year":"2010","journal-title":"Cell."},{"key":"10.1194\/jlr.D084228_bib52","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1021\/ac901282n","article-title":"Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry","volume":"81","author":"Yang","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1194\/jlr.D084228_bib53","doi-asserted-by":"crossref","first-page":"11721","DOI":"10.1021\/acs.analchem.5b02794","article-title":"Development and validation of a high-throughput ultrahigh-performance liquid chromatography-mass spectrometry approach for screening of oxylipins and their precursors","volume":"87","author":"Wolfer","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1194\/jlr.D084228_bib54","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1194\/jlr.M800200-JLR200","article-title":"Formation of eicosanoids, E2\/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain","volume":"49","author":"Farias","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D084228_bib55","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1194\/jlr.D700030-JLR200","article-title":"An improved LC-MS\/MS procedure for brain prostanoid analysis using brain fixation with head-focused microwave irradiation and liquid-liquid extraction","volume":"49","author":"Golovko","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D084228_bib56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.prostaglandins.2009.07.005","article-title":"Brain fixation for analysis of brain lipid-mediators of signal transduction and brain eicosanoids requires head-focused microwave irradiation: an historical perspective","volume":"91","author":"Murphy","year":"2010","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1194\/jlr.D084228_bib57","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0090-6980(83)90177-6","article-title":"In vivo regional levels of PGE and thromboxane in mouse brain: effect of decapitation, focused microwave fixation, and indomethacin","volume":"26","author":"Anton","year":"1983","journal-title":"Prostaglandins."},{"key":"10.1194\/jlr.D084228_bib58","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neulet.2007.12.031","article-title":"Brain prostaglandin formation is increased by alpha-synuclein gene-ablation during global ischemia","volume":"432","author":"Golovko","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1194\/jlr.D084228_bib59","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11745-016-4144-y","article-title":"Brain 2-arachidonoylglycerol levels are dramatically and rapidly increased under acute ischemia-injury which is prevented by microwave irradiation","volume":"51","author":"Brose","year":"2016","journal-title":"Lipids."},{"key":"10.1194\/jlr.D084228_bib60","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11064-005-2746-5","article-title":"Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain","volume":"30","author":"Bazinet","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1194\/jlr.D084228_bib61","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1126\/science.181.4096.280","article-title":"Cyclic adenosine monphosphate, metabolites, and phosphorylase in neural tissue: a comparison a methods of fixation","volume":"181","author":"Lust","year":"1973","journal-title":"Science."},{"key":"10.1194\/jlr.D084228_bib62","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1126\/science.173.4002.1142","article-title":"Cyclic adenosine monophosphate in brain areas: microwave irradiation as a means of tissue fixation","volume":"173","author":"Schmidt","year":"1971","journal-title":"Science."},{"key":"10.1194\/jlr.D084228_bib63","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1471-4159.1973.tb12135.x","article-title":"The use of microwave heating to inactivate cholinesterase in the rat brain prior to analysis for acetylcholine","volume":"20","author":"Stavinoha","year":"1973","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.D084228_bib64","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1161\/01.RES.87.12.1149","article-title":"Prolonged hypercapnia-evoked cerebral hyperemia via K(+) channel- and prostaglandin E(2)-dependent endothelial nitric oxide synthase induction","volume":"87","author":"Najarian","year":"2000","journal-title":"Circ. Res."},{"key":"10.1194\/jlr.D084228_bib65","doi-asserted-by":"crossref","first-page":"E100","DOI":"10.3390\/ani7120100","article-title":"Efficacy of blunt force trauma, a novel mechanical cervical dislocation device, and a non-penetrating captive bolt device for on-farm euthanasia of pre-weaned kits, growers, and adult commercial meat rabbits","volume":"7","author":"Walsh","year":"2017","journal-title":"Animals (Basel)."},{"key":"10.1194\/jlr.D084228_bib66","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0020-1790(87)90113-2","article-title":"Activation of crude and homogeneous juvenile hormone esterases by organic solvents","volume":"17","author":"Croston","year":"1987","journal-title":"Insect Biochem."},{"key":"10.1194\/jlr.D084228_bib67","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.eplepsyres.2011.12.001","article-title":"Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses","volume":"99","author":"Tr\u00e9panier","year":"2012","journal-title":"Epilepsy Res."},{"key":"10.1194\/jlr.D084228_bib68","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.plefa.2016.05.004","article-title":"Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid","volume":"138","author":"Taha","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids."},{"key":"10.1194\/jlr.D084228_bib69","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0\u2013making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.D084228_bib70","doi-asserted-by":"crossref","first-page":"14.10.1","DOI":"10.1002\/cpbi.11","article-title":"Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis","volume":"55","author":"Xia","year":"2016","journal-title":"Curr. Protoc. Bioinformatics."},{"key":"10.1194\/jlr.D084228_bib71","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/jnc.13934","article-title":"High-resolution lipidomics coupled with rapid fixation reveals novel ischemia-induced signaling in the rat neurolipidome","volume":"140","author":"Tr\u00e9panier","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.D084228_bib72","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF02620887","article-title":"Mechanical damage to murine neuronal-enriched cultures during harvesting: effects on free fatty acids, diglycerides, Na+,K+-ATPase, and lipid peroxidation","volume":"21","author":"Demediuk","year":"1985","journal-title":"In Vitro Cell. Dev. Biol."},{"key":"10.1194\/jlr.D084228_bib73","first-page":"1211","article-title":"Lipid mediators in cerebral spinal fluid of traumatic brain injured patients","volume":"71","author":"Farias","year":"2011","journal-title":"J. Trauma."},{"key":"10.1194\/jlr.D084228_bib74","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1471-4159.1973.tb12115.x","article-title":"Freeze-blowing: a new technique for the study of brain in vivo","volume":"20","author":"Veech","year":"1973","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.D084228_bib75","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1194\/jlr.M006262","article-title":"Extracellular-derived calcium does not initiate in vivo neurotransmission involving docosahexaenoic acid","volume":"51","author":"Ramadan","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.D084228_bib76","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.prostaglandins.2015.06.003","article-title":"Validation of a tandem mass spectrometry method using combined extraction of 37 oxylipins and 14 endocannabinoid-related compounds including prostamides from biological matrices","volume":"121","author":"Gouveia-Figueira","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520326274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520326274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.D084228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T16:48:15Z","timestamp":1637426895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520326274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0022227520326274"],"URL":"https:\/\/doi.org\/10.1194\/jlr.d084228","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain oxylipin concentrations following hypercapnia\/ischemia: effects of brain dissection and dissection time","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.D084228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 Hennebelle et al.","name":"copyright","label":"Copyright"}]}}