{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:29:43Z","timestamp":1773430183005,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":3849,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1194\/jlr.m002923","type":"journal-article","created":{"date-parts":[[2009,11,9]],"date-time":"2009-11-09T22:33:53Z","timestamp":1257806033000},"page":"1063-1074","source":"Crossref","is-referenced-by-count":40,"title":["Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge"],"prefix":"10.1016","volume":"51","author":[{"given":"Joo-Youn","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hoon","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher W.","family":"Krausz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Idle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Luecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M002923_bib1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science."},{"key":"10.1194\/jlr.M002923_bib2","first-page":"72","article-title":"Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors","volume":"9","author":"Seol","year":"1995","journal-title":"Mol. Endocrinol."},{"key":"10.1194\/jlr.M002923_bib3","doi-asserted-by":"crossref","first-page":"8190","DOI":"10.1016\/S0021-9258(19)39056-8","article-title":"Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis","volume":"265","author":"Jelinek","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M002923_bib4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/s-2000-9426","article-title":"Hepatic transport of bile salts","volume":"20","author":"Kullak-Ublick","year":"2000","journal-title":"Semin. Liver Dis."},{"key":"10.1194\/jlr.M002923_bib5","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0016-5085(03)01068-0","article-title":"Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice","volume":"125","author":"Wagner","year":"2003","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M002923_bib6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"Sinal","year":"2000","journal-title":"Cell."},{"key":"10.1194\/jlr.M002923_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1021\/mp060010s","article-title":"Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations","volume":"3","author":"Zollner","year":"2006","journal-title":"Mol. Pharm."},{"key":"10.1194\/jlr.M002923_bib8","doi-asserted-by":"crossref","first-page":"G923","DOI":"10.1152\/ajpgi.00490.2005","article-title":"Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha\/beta in the adaptive response to bile acids","volume":"290","author":"Zollner","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1194\/jlr.M002923_bib9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cmet.2007.10.005","article-title":"Metabolomics","volume":"6","author":"Idle","year":"2007","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M002923_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/03602530701497804","article-title":"LC-MS-based metabolomics in drug metabolism","volume":"39","author":"Chen","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1194\/jlr.M002923_bib11","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1210\/me.2007-0150","article-title":"Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation","volume":"21","author":"Zhen","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1194\/jlr.M002923_bib12","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1194\/jlr.M800647-JLR200","article-title":"Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation","volume":"50","author":"Cho","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M002923_bib13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0008-6215(00)00326-8","article-title":"Syntheses of daidzein-7-yl beta-D-glucopyranosiduronic acid and daidzein-4\u2032,7-yl di-beta-D-glucopyranosiduronic acid","volume":"330","author":"Needs","year":"2001","journal-title":"Carbohydr. Res."},{"key":"10.1194\/jlr.M002923_bib14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/0039-128X(90)90048-G","article-title":"Potential bile acid metabolites. 16. Synthesis of stereoisomeric 3 alpha,6,7,12 alpha-tetrahydroxy-5 beta-cholanoic acids","volume":"55","author":"Iida","year":"1990","journal-title":"Steroids."},{"key":"10.1194\/jlr.M002923_bib15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/jo00109a027","article-title":"An efficient synthesis of glycoprotein IIb\/IIIa inhibitor DMP728. A novel synthesis of N\u03b1-methylarginine-containing peptide","volume":"60","author":"Xue","year":"1995","journal-title":"J. Org. Chem."},{"key":"10.1194\/jlr.M002923_bib16","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1055\/s-1995-5101","article-title":"Microwave-induced rapid synthesis of bile-acid conjugates","author":"Dayal","year":"1995","journal-title":"Synlett."},{"key":"10.1194\/jlr.M002923_bib17","doi-asserted-by":"crossref","first-page":"45062","DOI":"10.1074\/jbc.M307145200","article-title":"Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity","volume":"278","author":"Guo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M002923_bib18","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1194\/jlr.M500427-JLR200","article-title":"Fxr(\u2212\/\u2212) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids","volume":"47","author":"Marschall","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M002923_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1081\/DMR-200033475","article-title":"Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity","volume":"36","author":"Hofmann","year":"2004","journal-title":"Drug Metab. Rev."},{"key":"10.1194\/jlr.M002923_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1079\/BJN19830014","article-title":"The origin of urinary aromatic compounds excreted by ruminants. 4. The potential use of urine aromatic acid and phenol outputs as a measure of voluntary food intake","volume":"49","author":"Martin","year":"1983","journal-title":"Br. J. Nutr."},{"key":"10.1194\/jlr.M002923_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/aem.53.1.189-192.1987","article-title":"Isolation from swine feces of a bacterium which decarboxylates p-hydroxyphenylacetic acid to 4-methylphenol (p-cresol)","volume":"53","author":"Ward","year":"1987","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1194\/jlr.M002923_bib22","first-page":"292","article-title":"Clinical applications of urinary organic acids. Part 2. Dysbiosis markers","volume":"13","author":"Lord","year":"2008","journal-title":"Altern. Med. Rev."},{"key":"10.1194\/jlr.M002923_bib23","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1073\/pnas.0812874106","article-title":"Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites","volume":"106","author":"Wikoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M002923_bib24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1053\/jhep.2003.50116","article-title":"Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats","volume":"37","author":"Lorenzo-Zuniga","year":"2003","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M002923_bib25","first-page":"G987","article-title":"Tumor necrosis factor-alpha stimulates adrenal glucocorticoid secretion in cholestatic rats","volume":"270","author":"Swain","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1194\/jlr.M002923_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0016-6480(02)00620-2","article-title":"Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice","volume":"130","author":"Touma","year":"2003","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1194\/jlr.M002923_bib27","doi-asserted-by":"crossref","first-page":"13703","DOI":"10.1016\/S0021-9258(17)43974-3","article-title":"Metabolism of corticosterone in the mouse. Identification of 11 beta, 20 alpha-dihydroxy-3-oxo-4-pregnen-21-oic acid as a major metabolite","volume":"258","author":"Han","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M002923_bib28","doi-asserted-by":"crossref","first-page":"47154","DOI":"10.1074\/jbc.M107000200","article-title":"Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids","volume":"276","author":"Sinal","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M002923_bib29","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1194\/jlr.M200394-JLR200","article-title":"Appearance of atypical 3 alpha,6 beta,7 beta,12 alpha-tetrahydroxy-5 beta-cholan-24-oic acid in spgp knockout mice","volume":"44","author":"Perwaiz","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M002923_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M002923_bib31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbalip.2004.11.003","article-title":"Novel pathways of bile acid metabolism involving CYP3A4","volume":"1687","author":"Bodin","year":"2005","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M002923_bib32","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.051014398","article-title":"An essential role for nuclear receptors SXR\/PXR in detoxification of cholestatic bile acids","volume":"98","author":"Xie","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M002923_bib33","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M002923_bib34","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2353\/ajpath.2006.050404","article-title":"Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice","volume":"168","author":"Fickert","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1194\/jlr.M002923_bib35","doi-asserted-by":"crossref","first-page":"17838","DOI":"10.1074\/jbc.M210634200","article-title":"Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity","volume":"278","author":"Kitada","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M002923_bib36","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1070477","article-title":"Vitamin D receptor as an intestinal bile acid sensor","volume":"296","author":"Makishima","year":"2002","journal-title":"Science."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520410624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520410624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M002923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T17:08:28Z","timestamp":1637428108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520410624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0022227520410624"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m002923","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3521957.3221055","asserted-by":"object"}]},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}