{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:01:39Z","timestamp":1791302499122,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":3238,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1194\/jlr.m017566","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T06:09:53Z","timestamp":1317103793000},"page":"2136-2147","source":"Crossref","is-referenced-by-count":88,"title":["Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis"],"prefix":"10.1016","volume":"52","author":[{"given":"Weihua","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghou","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar S.","family":"Kapterian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bielby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M017566_bib1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2009.11.005","article-title":"Lipid droplets finally get a little R-E-S-P-E-C-T","volume":"139","author":"Farese","year":"2009","journal-title":"Cell."},{"key":"10.1194\/jlr.M017566_bib2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.cmet.2008.11.001","article-title":"Before they were fat: adipocyte progenitors","volume":"8","author":"Park","year":"2008","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M017566_bib3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","article-title":"Developmental origin of fat: tracking obesity to its source","volume":"131","author":"Gesta","year":"2007","journal-title":"Cell."},{"key":"10.1194\/jlr.M017566_bib4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.med.57.022605.114424","article-title":"Genetic basis of lipodystrophies and management of metabolic complications","volume":"57","author":"Agarwal","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"10.1194\/jlr.M017566_bib5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magr\u00e9","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M017566_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"Agarwal","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M017566_bib7","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2007-1328","article-title":"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy","volume":"93","author":"Kim","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.M017566_bib8","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1172\/JCI38660","article-title":"Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy","volume":"119","author":"Hayashi","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M017566_bib9","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cmet.2008.07.008","article-title":"Deletion of Cavin\/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance","volume":"8","author":"Liu","year":"2008","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M017566_bib10","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.febslet.2006.03.040","article-title":"Membrane topology of the human seipin protein","volume":"580","author":"Lundin","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1194\/jlr.M017566_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ng1313","article-title":"Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome","volume":"36","author":"Windpassinger","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M017566_bib12","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.2337\/db08-0184","article-title":"The human lipodystrophy gene BSCL2\/seipin may be essential for normal adipocyte differentiation","volume":"57","author":"Payne","year":"2008","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M017566_bib13","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1210\/en.2009-0236","article-title":"The human lipodystrophy gene product BSCL2\/seipin plays a key role in adipocyte differentiation","volume":"150","author":"Chen","year":"2009","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M017566_bib14","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/hmg\/ddr205","article-title":"Seipin ablation in mice results in severe generalized lipodystrophy","volume":"20","author":"Cui","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.M017566_bib15","doi-asserted-by":"crossref","first-page":"e1001364","DOI":"10.1371\/journal.pgen.1001364","article-title":"Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation","volume":"7","author":"Tian","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1194\/jlr.M017566_bib16","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.biochi.2009.01.011","article-title":"Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy","volume":"91","author":"Boutet","year":"2009","journal-title":"Biochimie."},{"key":"10.1194\/jlr.M017566_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200711136","article-title":"Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast","volume":"180","author":"Fei","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1194\/jlr.M017566_bib18","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","article-title":"The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology","volume":"104","author":"Szymanski","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M017566_bib19","doi-asserted-by":"crossref","first-page":"10747","DOI":"10.1021\/bi1013003","article-title":"Seipin is a discrete homooligomer","volume":"49","author":"Binns","year":"2010","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.M017566_bib20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tem.2011.02.004","article-title":"Seipin, adipogenesis and lipid droplets","volume":"22","author":"Fei","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1194\/jlr.M017566_bib21","doi-asserted-by":"crossref","first-page":"e1002201","DOI":"10.1371\/journal.pgen.1002201","article-title":"A role for phosphatidic acid in the formation of \u201csupersized\u201d lipid droplets","volume":"7","author":"Fei","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1194\/jlr.M017566_bib22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.nbd.2008.05.004","article-title":"Characterization of seipin\/BSCL2, a protein associated with spastic paraplegia 17","volume":"31","author":"Ito","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1194\/jlr.M017566_bib23","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.molmed.2004.07.009","article-title":"Seipin: a mysterious protein","volume":"10","author":"Agarwal","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1194\/jlr.M017566_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ana.21070","article-title":"Molecular pathogenesis of seipin\/BSCL2-related motor neuron diseases","volume":"61","author":"Ito","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1194\/jlr.M017566_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BJ20090785","article-title":"Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae","volume":"424","author":"Fei","year":"2009","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M017566_bib26","doi-asserted-by":"crossref","first-page":"38870","DOI":"10.1074\/jbc.M106219200","article-title":"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members","volume":"276","author":"Cases","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M017566_bib27","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1073\/pnas.0500206102","article-title":"Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change","volume":"102","author":"Feramisco","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M017566_bib28","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1126\/science.7792603","article-title":"Transcriptional activation by tetracyclines in mammalian cells","volume":"268","author":"Gossen","year":"1995","journal-title":"Science."},{"key":"10.1194\/jlr.M017566_bib29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1194\/jlr.M013003","article-title":"DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes","volume":"52","author":"Harris","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M017566_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bbalip.2006.07.010","article-title":"Metabolism of phosphatidylcholine and its implications for lipid acyl chain composition in Saccharomyces cerevisiae","volume":"1771","author":"de Kroon","year":"2007","journal-title":"Biochim. Biophys. Acta."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520408181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520408181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M017566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T21:56:19Z","timestamp":1637445379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520408181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0022227520408181"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m017566","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}