{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:16:16Z","timestamp":1768342576179,"version":"3.49.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":2992,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1194\/jlr.m025239","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T02:39:50Z","timestamp":1337827190000},"page":"1493-1501","source":"Crossref","is-referenced-by-count":10,"title":["Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis"],"prefix":"10.1016","volume":"53","author":[{"given":"Chen-Yu","family":"Wang\u738b\u798e\u9685","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald S.","family":"Stapleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn L.","family":"Schueler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Rabaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angie T.","family":"Oler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina M.","family":"Kendziorski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl W.","family":"Broman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S.","family":"Yandell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric E.","family":"Schadt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan D.","family":"Attie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M025239_bib1","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1542\/peds.2006-1212","article-title":"Prevalence of fatty liver in children and adolescents","volume":"118","author":"Schwimmer","year":"2006","journal-title":"Pediatrics."},{"key":"10.1194\/jlr.M025239_bib2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1464-5491.2005.01748.x","article-title":"Recent concepts in non- alcoholic fatty liver disease","volume":"22","author":"Adams","year":"2005","journal-title":"Diabet. Med."},{"key":"10.1194\/jlr.M025239_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","article-title":"The natural history of nonalcoholic fatty liver disease: a population-based cohort study","volume":"129","author":"Adams","year":"2005","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M025239_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cld.2004.04.004","article-title":"The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease","volume":"8","author":"McCullough","year":"2004","journal-title":"Clin. Liver Dis."},{"key":"10.1194\/jlr.M025239_bib6","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M025239_bib7","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/hep.22142","article-title":"Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH","volume":"47","author":"Musso","year":"2008","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M025239_bib8","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M025239_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-230X-8-27","article-title":"Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)","volume":"8","author":"Yoneda","year":"2008","journal-title":"BMC Gastro enterol."},{"key":"10.1194\/jlr.M025239_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7861\/clinmedicine.6-1-19","article-title":"Non-alcoholic fatty liver disease: current concepts and management strategies","volume":"6","author":"Day","year":"2006","journal-title":"Clin. Med."},{"key":"10.1194\/jlr.M025239_bib12","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1534\/genetics.103.024521","article-title":"A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines","volume":"167","author":"Bilger","year":"2004","journal-title":"Genetics."},{"key":"10.1194\/jlr.M025239_bib14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/er.2006-0035","article-title":"The genetic landscape of type 2 diabetes in mice","volume":"28","author":"Clee","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1194\/jlr.M025239_bib17","first-page":"27","article-title":"Genetic analysis of resistance to infections in mice: A\/J meets C57BL\/6J","volume":"321","author":"Marquis","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1194\/jlr.M025239_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.nutr.21.1.193","article-title":"Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system","volume":"21","author":"Reddy","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"10.1194\/jlr.M025239_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.20783","article-title":"Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice","volume":"42","author":"Yu","year":"2005","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M025239_bib22","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1053\/j.gastro.2010.07.057","article-title":"Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease","volume":"139","author":"Chalasani","year":"2010","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M025239_bib23","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1101\/gr.074914.107","article-title":"A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility","volume":"18","author":"Keller","year":"2008","journal-title":"Genome Res."},{"key":"10.1194\/jlr.M025239_bib24","doi-asserted-by":"crossref","first-page":"e1002323","DOI":"10.1371\/journal.pgen.1002323","article-title":"Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion","volume":"7","author":"Bhatnagar","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1194\/jlr.M025239_bib25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2337\/diabetes.52.3.688","article-title":"Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility","volume":"52","author":"Lan","year":"2003","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M025239_bib26","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/bioinformatics\/btg112","article-title":"R\/qtl: QTL mapping in experimental crosses","volume":"19","author":"Broman","year":"2003","journal-title":"Bioinformatics."},{"key":"10.1194\/jlr.M025239_bib27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","article-title":"Empirical threshold values for quantitative trait mapping","volume":"138","author":"Churchill","year":"1994","journal-title":"Genetics."},{"key":"10.1194\/jlr.M025239_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1534\/genetics.106.061549","article-title":"Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus","volume":"174","author":"Manichaikul","year":"2006","journal-title":"Genetics."},{"key":"10.1194\/jlr.M025239_bib29","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1038\/sj.onc.1204009","article-title":"The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination","volume":"19","author":"Benvenuto","year":"2000","journal-title":"Oncogene."},{"key":"10.1194\/jlr.M025239_bib31","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Inoki","year":"2003","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M025239_bib32","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1016\/j.febslet.2005.07.054","article-title":"Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1","volume":"579","author":"Tee","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1194\/jlr.M025239_bib33","doi-asserted-by":"crossref","first-page":"39921","DOI":"10.1074\/jbc.M306553200","article-title":"Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K","volume":"278","author":"Tabancay","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M025239_bib34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1172\/JCI7319","article-title":"Tsc2(+\/\u2212) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background","volume":"104","author":"Onda","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M025239_bib35","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1073\/pnas.0803047105","article-title":"Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner","volume":"105","author":"Rachdi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M025239_bib36","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1210\/en.2010-0048","article-title":"Role of the TSC1\u2013TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation","volume":"151","author":"Bartolome","year":"2010","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M025239_bib37","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1074\/jbc.C500451200","article-title":"TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase","volume":"281","author":"Chong-Kopera","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M025239_bib42","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1089\/gte.2005.9.226","article-title":"Large deletion at the TSC1 locus in a family with tuberous sclerosis complex","volume":"9","author":"Nellist","year":"2005","journal-title":"Genet. Test."},{"key":"10.1194\/jlr.M025239_bib43","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1093\/hmg\/10.25.2899","article-title":"Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin","volume":"10","author":"Hodges","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.M025239_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/ng0992-37","article-title":"Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease","volume":"2","author":"Kandt","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M025239_bib45","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science."},{"key":"10.1194\/jlr.M025239_bib46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","article-title":"The TSC1\u2013TSC2 complex: a molecular switchboard controlling cell growth","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M025239_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng1494","article-title":"Dysregulation of the TSC-mTOR pathway in human disease","volume":"37","author":"Inoki","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M025239_bib48","doi-asserted-by":"crossref","first-page":"e6189","DOI":"10.1371\/journal.pone.0006189","article-title":"Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway","volume":"4","author":"Zhang","year":"2009","journal-title":"PLoS ONE."},{"key":"10.1194\/jlr.M025239_bib49","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molcel.2010.06.022","article-title":"Activation of a metabolic gene regulatory network downstream of mTOR complex 1","volume":"39","author":"Duvel","year":"2010","journal-title":"Mol. Cell."},{"key":"10.1194\/jlr.M025239_bib50","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1073\/pnas.0914798107","article-title":"Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M025239_bib51","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/db09-1602","article-title":"Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage","volume":"59","author":"Chakrabarti","year":"2010","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M025239_bib52","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2011.06.034","article-title":"mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway","volume":"146","author":"Peterson","year":"2011","journal-title":"Cell."},{"key":"10.1194\/jlr.M025239_bib53","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1083\/jcb.200408161","article-title":"Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis","volume":"167","author":"Manning","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1194\/jlr.M025239_bib54","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.molcel.2007.03.003","article-title":"PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase","volume":"25","author":"Sancak","year":"2007","journal-title":"Mol. Cell."},{"key":"10.1194\/jlr.M025239_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2011.06.002","article-title":"Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways","volume":"14","author":"Yecies","year":"2011","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M025239_bib56","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cmet.2011.09.001","article-title":"Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c","volume":"14","author":"Wan","year":"2011","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M025239_bib57","doi-asserted-by":"crossref","first-page":"E980","DOI":"10.1152\/ajpendo.00333.2004","article-title":"Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside","volume":"288","author":"Reiter","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1194\/jlr.M025239_bib58","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bbrc.2008.07.025","article-title":"AMPK represses TOP mRNA translation but not global protein synthesis in liver","volume":"374","author":"Reiter","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.M025239_bib59","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1093\/hmg\/ddp236","article-title":"Diet-induced hepatocellular carcinoma in genetically predisposed mice","volume":"18","author":"Hill-Baskin","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.M025239_bib61","doi-asserted-by":"crossref","unstructured":"Bugianesi, E., 2007. Non-alcoholic steatohepatitis and cancer. Clin. Liver Dis., 11: 191\u2013207. (x\u2013xi.).","DOI":"10.1016\/j.cld.2007.02.006"},{"key":"10.1194\/jlr.M025239_bib62","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1158\/1535-7163.MCT-09-0055","article-title":"Renal and liver tumors in Tsc2(+\/\u2212) mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor","volume":"8","author":"Finlay","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1194\/jlr.M025239_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1503\/cmaj.045232","article-title":"Nonalcoholic fatty liver disease","volume":"172","author":"Adams","year":"2005","journal-title":"Can. Med. Assoc. J."},{"key":"10.1194\/jlr.M025239_bib9","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.3748\/wjg.v13.i31.4242","article-title":"Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease","volume":"13","author":"Sookoian","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1194\/jlr.M025239_bib13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/carcin\/bgn038","article-title":"Widespread hyperplasia induced by transgenic TGFalpha in ApcMin mice is associated with only regional effects on tumorigenesis","volume":"29","author":"Bilger","year":"2008","journal-title":"Carcinogenesis."},{"key":"10.1194\/jlr.M025239_bib15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/ng1796","article-title":"Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus","volume":"38","author":"Clee","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M025239_bib16","doi-asserted-by":"crossref","unstructured":"Kotb, M., Fathey, N., Aziz, R., Rowe, S., Williams, R. W., Lu, L., . 2008. Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections. Novartis Found. Symp. 293: 156\u2013165; discussion 165\u2013157, 181\u2013153.","DOI":"10.1002\/9780470696781.ch12"},{"key":"10.1194\/jlr.M025239_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/75651","article-title":"Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat","volume":"25","author":"Smith","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M025239_bib20","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1371\/journal.pgen.0010023","article-title":"Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice","volume":"1","author":"Tolwani","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1194\/jlr.M025239_bib30","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1194\/jlr.M025239_bib38","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1194\/jlr.M025239_bib39","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4161\/cbt.2.5.446","article-title":"Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis","volume":"2","author":"Kwiatkowski","year":"2003","journal-title":"Cancer Biol. Ther."},{"key":"10.1194\/jlr.M025239_bib40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1469-1809.2003.00012.x","article-title":"Tuberous sclerosis: from tubers to mTOR","volume":"67","author":"Kwiatkowski","year":"2003","journal-title":"Ann. Hum. Genet."},{"key":"10.1194\/jlr.M025239_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.ejhg.5201276","article-title":"Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex","volume":"13","author":"Nellist","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1194\/jlr.M025239_bib60","first-page":"5016","article-title":"Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition?","volume":"61","author":"Yang","year":"2001","journal-title":"Cancer Res."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752041853X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002222752041853X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M025239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T22:49:26Z","timestamp":1637448566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002222752041853X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S002222752041853X"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m025239","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}