{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:31:00Z","timestamp":1790274660141,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":2991,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1194\/jlr.m025445","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T05:35:04Z","timestamp":1334640904000},"page":"1316-1326","source":"Crossref","is-referenced-by-count":54,"title":["Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease"],"prefix":"10.1016","volume":"53","author":[{"given":"Shahzada","family":"Amir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Hartvigsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Gonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Leibundgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchu","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Jensen-Jarolim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswald","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Tsimikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Witztum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M025445_bib1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nm1102-1218","article-title":"Innate and acquired immunity in atherogenesis","volume":"8","author":"Binder","year":"2002","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.M025445_bib2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/CIRCRESAHA.110.223875","article-title":"Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity","volume":"108","author":"Miller","year":"2011","journal-title":"Circ. Res."},{"key":"10.1194\/jlr.M025445_bib3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1073\/pnas.86.4.1372","article-title":"Low density lipoprotein undergoes oxidative modification in vivo","volume":"86","author":"Palinski","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M025445_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.ATV.14.1.32","article-title":"Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL","volume":"14","author":"Yl\u00e4-Herttuala","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"10.1194\/jlr.M025445_bib5","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1172\/JCI114271","article-title":"Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man","volume":"84","author":"Yl\u00e4-Herttuala","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M025445_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1161\/01.ATV.21.1.95","article-title":"Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient mice","volume":"21","author":"Tsimikas","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M025445_bib7","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1161\/01.CIR.103.18.2277","article-title":"Absence of 12\/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice","volume":"103","author":"Cyrus","year":"2001","journal-title":"Circulation."},{"key":"10.1194\/jlr.M025445_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1182\/blood.V97.2.459","article-title":"Circulating autoantibodies to oxidized cardiolipin correlate with isoprostane F(2alpha)-VI levels and the extent of atherosclerosis in ApoE-deficient mice: modulation by vitamin E","volume":"97","author":"Pratic\u00f2","year":"2001","journal-title":"Blood."},{"key":"10.1194\/jlr.M025445_bib9","first-page":"821","article-title":"Antibodies to oxidized low density lipoprotein: epidemiological studies and potential clinical applications in cardiovascular disease","volume":"55","author":"Gounopoulos","year":"2007","journal-title":"Minerva Cardioangiol."},{"key":"10.1194\/jlr.M025445_bib10","doi-asserted-by":"crossref","first-page":"9P","DOI":"10.1016\/j.amjcard.2006.09.015","article-title":"Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease","volume":"98","author":"Tsimikas","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"10.1194\/jlr.M025445_bib11","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1194\/jlr.M015776","article-title":"Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study","volume":"52","author":"Ravandi","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M025445_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clim.2009.04.001","article-title":"Clinical significance of the humoral immune response to modified LDL","volume":"134","author":"Lopes-Virella","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1194\/jlr.M025445_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1194\/jlr.M600361-JLR200","article-title":"Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events","volume":"48","author":"Tsimikas","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M025445_bib14","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1172\/JCI36800","article-title":"Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans","volume":"119","author":"Chou","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M025445_bib15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1073\/pnas.92.3.821","article-title":"Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis","volume":"92","author":"Palinski","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M025445_bib16","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1161\/01.ATV.18.12.1972","article-title":"Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes","volume":"18","author":"Freigang","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M025445_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1172\/JCI200420479","article-title":"IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis","volume":"114","author":"Binder","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M025445_bib18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9150(98)00015-X","article-title":"Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis","volume":"138","author":"George","year":"1998","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M025445_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.ATV.0000067937.93716.DB","article-title":"Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences","volume":"23","author":"Fredrikson","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M025445_bib20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/01.ATV.21.1.108","article-title":"LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis","volume":"21","author":"Zhou","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M025445_bib21","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.jacc.2011.07.017","article-title":"Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression","volume":"58","author":"Tsimikas","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.M025445_bib22","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.freeradbiomed.2010.08.001","article-title":"Malondialdehyde\u2013acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis","volume":"49","author":"Duryee","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1194\/jlr.M025445_bib23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jacc.2007.04.054","article-title":"Promise of immune modulation to inhibit atherogenesis","volume":"50","author":"Binder","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.M025445_bib24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.clim.2009.07.009","article-title":"Experimental immunotherapeutic approaches for atherosclerosis","volume":"134","author":"Amir","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1194\/jlr.M025445_bib25","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1161\/01.ATV.0000233333.07991.4a","article-title":"A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions","volume":"26","author":"Tuominen","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M025445_bib26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1172\/JCI4533","article-title":"Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins","volume":"103","author":"H\u00f6rkk\u00f6","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M025445_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.ATV.10.3.325","article-title":"Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein","volume":"10","author":"Palinski","year":"1990","journal-title":"Arteriosclerosis."},{"key":"10.1194\/jlr.M025445_bib28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/hq0801.093587","article-title":"Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo","volume":"21","author":"Shaw","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M025445_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.atherosclerosis.2006.09.028","article-title":"Identification of atherosclerosis-associated conformational heat shock protein 60 epitopes by phage display and structural alignment","volume":"194","author":"Perschinka","year":"2007","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M025445_bib30","doi-asserted-by":"crossref","first-page":"44385","DOI":"10.1074\/jbc.M304047200","article-title":"Mapping of a conformational epitope shared between E1 and E2 on the serum-derived human hepatitis C virus envelope","volume":"278","author":"Petit","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M025445_bib31","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nm876","article-title":"Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL","volume":"9","author":"Binder","year":"2003","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.M025445_bib32","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1161\/01.CIR.0000130844.01174.55","article-title":"Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein","volume":"109","author":"Tsimikas","year":"2004","journal-title":"Circulation."},{"key":"10.1194\/jlr.M025445_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0022-1759(85)90044-4","article-title":"Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay","volume":"77","author":"Friguet","year":"1985","journal-title":"J. Immunol. Methods."},{"key":"10.1194\/jlr.M025445_bib34","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1194\/jlr.M005769","article-title":"Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet","volume":"51","author":"Faghihnia","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M025445_bib35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0735-1097(02)02769-9","article-title":"Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes","volume":"41","author":"Tsimikas","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.M025445_bib36","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.4049\/jimmunol.168.12.6273","article-title":"Peptide mimotopes of pneumococcal capsular polysaccharide of 6B serotype: a peptide mimotope can bind to two unrelated antibodies","volume":"168","author":"Shin","year":"2002","journal-title":"J. Immunol."},{"key":"10.1194\/jlr.M025445_bib37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.bb.20.060191.002511","article-title":"Defining solution conformations of small linear peptides","volume":"20","author":"Dyson","year":"1991","journal-title":"Annu. Rev. Biophys. Biophys. Chem."},{"key":"10.1194\/jlr.M025445_bib38","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2174\/1389203043379314","article-title":"Design of synthetic peptidic constructs for the vaccine development against viral infections","volume":"5","author":"Haro","year":"2004","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1194\/jlr.M025445_bib39","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1084\/jem.20031763","article-title":"Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory","volume":"200","author":"Chang","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1194\/jlr.M025445_bib40","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1073\/pnas.96.11.6353","article-title":"Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition","volume":"96","author":"Chang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M025445_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/128_2007_18","article-title":"Structural and functional studies of peptide-carbohydrate mimicry","volume":"273","author":"Johnson","year":"2008","journal-title":"Top. Curr. Chem."},{"key":"10.1194\/jlr.M025445_bib42","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1128\/IAI.73.1.325-333.2005","article-title":"A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice","volume":"73","author":"Buchwald","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1194\/jlr.M025445_bib43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0161-5890(02)00116-5","article-title":"Regulating the isotypic and idiotypic profile of an anti-PC antibody response: lessons from peptide mimics","volume":"39","author":"Harris","year":"2002","journal-title":"Mol. Immunol."},{"key":"10.1194\/jlr.M025445_bib44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0167-7799(02)01940-6","article-title":"Peptide mimotopes as surrogate antigens of carbohydrates in vaccine discovery","volume":"20","author":"Monzavi-Karbassi","year":"2002","journal-title":"Trends Biotechnol."},{"key":"10.1194\/jlr.M025445_bib45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12410-010-9060-6","article-title":"Imaging of oxidation-specific epitopes in atherosclerosis and macrophage-rich vulnerable plaques","volume":"4","author":"Briley-Saebo","year":"2011","journal-title":"Curr. Cardiovasc. Imaging. Rep."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520345089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520345089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M025445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T18:21:29Z","timestamp":1637432489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520345089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0022227520345089"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m025445","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}