{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:01:48Z","timestamp":1791090108909,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":2991,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1194\/jlr.m026054","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T04:46:56Z","timestamp":1335329216000},"page":"1384-1389","source":"Crossref","is-referenced-by-count":20,"title":["The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin"],"prefix":"10.1016","volume":"53","author":[{"given":"Miao","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S.H.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-Shan","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund K.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M026054_bib1","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1161\/01.ATV.0000178994.21828.a7","article-title":"The farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism","volume":"25","author":"Claudel","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M026054_bib2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.tem.2011.07.002","article-title":"Hepatic FXR: key regulator of whole-body energy metabolism","volume":"22","author":"Teodoro","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1194\/jlr.M026054_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tips.2007.03.002","article-title":"FXR: a promising target for the metabolic syndrome?","volume":"28","author":"Cariou","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1194\/jlr.M026054_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-3-642-14541-4_10","article-title":"Molecular mechanisms of drug transporter regulation","author":"Tirona","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1194\/jlr.M026054_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1517\/17425255.2011.538383","article-title":"The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins","volume":"7","author":"Hu","year":"2011","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1194\/jlr.M026054_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/clpt.2009.197","article-title":"Transporter pharmacogenetics and statin toxicity","volume":"87","author":"Niemi","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1194\/jlr.M026054_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/tpj.2009.54","article-title":"The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy","volume":"10","author":"Romaine","year":"2010","journal-title":"Pharmacogenomics J."},{"key":"10.1194\/jlr.M026054_bib8","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/hep.23876","article-title":"Liver X receptor alpha and farnesoid X receptor are major transcriptional regulators of OATP1B1","volume":"52","author":"Meyer Zu Schwabedissen","year":"2010","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M026054_bib9","doi-asserted-by":"crossref","first-page":"35669","DOI":"10.1074\/jbc.M103792200","article-title":"Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans","volume":"276","author":"Tirona","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M026054_bib10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/ijc.11669","article-title":"Single nucleotide polymorphisms result in impaired membrane localization and reduced ATPase activity in multidrug transporter ABCG2","volume":"109","author":"Mizuarai","year":"2004","journal-title":"Int. J. Cancer."},{"key":"10.1194\/jlr.M026054_bib11","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1074\/jbc.M109326200","article-title":"Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor","volume":"277","author":"Kast","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M026054_bib12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/gast.2001.25503","article-title":"The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp","volume":"121","author":"Denson","year":"2001","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M026054_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00535-006-1784-3","article-title":"Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene","volume":"41","author":"Ohtsuka","year":"2006","journal-title":"J. Gastroenterol."},{"key":"10.1194\/jlr.M026054_bib14","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1210\/me.2007-0025","article-title":"A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression","volume":"21","author":"Marzolini","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1194\/jlr.M026054_bib15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2007.05.015","article-title":"Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy","volume":"133","author":"Van Mil","year":"2007","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M026054_bib16","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1053\/j.gastro.2006.02.034","article-title":"Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics","volume":"130","author":"Ho","year":"2006","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M026054_bib17","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1124\/dmd.105.007534","article-title":"ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein","volume":"34","author":"Huang","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1194\/jlr.M026054_bib18","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1124\/dmd.108.021410","article-title":"Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin","volume":"36","author":"Kitamura","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1194\/jlr.M026054_bib19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/FPC.0b013e32833de489","article-title":"Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients","volume":"20","author":"Hu","year":"2010","journal-title":"Pharmacogenet. Genomics."},{"key":"10.1194\/jlr.M026054_bib20","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/clpt.2009.232","article-title":"ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin","volume":"87","author":"Tomlinson","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1194\/jlr.M026054_bib21","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation."},{"key":"10.1194\/jlr.M026054_bib22","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA."},{"key":"10.1194\/jlr.M026054_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.M026054_bib24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/0091270007299930","article-title":"Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs","volume":"47","author":"Urquhart","year":"2007","journal-title":"J. Clin. Pharmacol."},{"key":"10.1194\/jlr.M026054_bib25","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1056\/NEJMoa0801936","article-title":"SLCO1B1 variants and statin-induced myopathy\u2013a genomewide study","volume":"359","author":"Link","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M026054_bib26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.clpt.2005.06.013","article-title":"Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment","volume":"78","author":"Lee","year":"2005","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1194\/jlr.M026054_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/pr.110.002857","article-title":"Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake","volume":"63","author":"Niemi","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1194\/jlr.M026054_bib28","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/01.fpc.0000215070.52212.0e","article-title":"Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin","volume":"16","author":"Niemi","year":"2006","journal-title":"Pharmacogenet. Genomics."},{"key":"10.1194\/jlr.M026054_bib29","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.tiv.2009.10.009","article-title":"Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes","volume":"24","author":"Jemnitz","year":"2010","journal-title":"Toxicol. In Vitro."},{"key":"10.1194\/jlr.M026054_bib30","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1053\/jhep.2002.31724","article-title":"Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump","volume":"35","author":"Plass","year":"2002","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M026054_bib31","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1124\/dmd.106.010033","article-title":"Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes","volume":"34","author":"Jigorel","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1194\/jlr.M026054_bib32","doi-asserted-by":"crossref","first-page":"19081","DOI":"10.1074\/jbc.M600116200","article-title":"Pregnane X receptor is a target of farnesoid X receptor","volume":"281","author":"Jung","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M026054_bib33","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1074\/jbc.M209525200","article-title":"The farnesoid X-receptor is an essential regulator of cholesterol homeostasis","volume":"278","author":"Lambert","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M026054_bib34","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1194\/jlr.M800619-JLR200","article-title":"Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR\u2212\/\u2212 and apoE\u2212\/\u2212 mice","volume":"50","author":"Hartman","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M026054_bib35","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1073\/pnas.0506982103","article-title":"Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M026054_bib36","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1172\/JCI21025","article-title":"Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c","volume":"113","author":"Watanabe","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M026054_bib37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3109\/00498254.2011.569773","article-title":"The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes","volume":"41","author":"Howe","year":"2011","journal-title":"Xenobiotica."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520345156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520345156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M026054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T18:21:54Z","timestamp":1637432514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520345156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0022227520345156"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m026054","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}