{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T08:52:05Z","timestamp":1753519925592},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":1604,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1194\/jlr.m058446","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T07:27:58Z","timestamp":1462087678000},"page":"882-893","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["In silico modeling of the dynamics of low density lipoprotein composition via a single plasma sample"],"prefix":"10.1016","volume":"57","author":[{"given":"Martin","family":"Jansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Pfaffelhuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Puetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M058446_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/01.CIR.82.2.495","article-title":"Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk","volume":"82","author":"Austin","year":"1990","journal-title":"Circulation."},{"key":"10.1194\/jlr.M058446_bib2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI103182","article-title":"The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum","volume":"34","author":"Havel","year":"1955","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M058446_bib3","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1001\/jama.1988.03410130125037","article-title":"Low-density lipoprotein subclass patterns and risk of myocardial infarction","volume":"260","author":"Austin","year":"1988","journal-title":"J. Am. Med. Assoc."},{"key":"10.1194\/jlr.M058446_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/eurheartj\/ehu055","article-title":"Low-density lipoprotein particle diameter and mortality: the Ludwigshafen Risk and Cardiovascular Health Study","volume":"36","author":"Grammer","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1194\/jlr.M058446_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0005-2760(83)90283-7","article-title":"Evidence that lecithin:cholesterol acyltransferase acts on both high-density and low-density lipoproteins","volume":"751","author":"Barter","year":"1983","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M058446_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0005-2760(94)90215-1","article-title":"Analysis of the selective uptake of the cholesteryl ester of human intermediate density lipoproteins by HepG2 cells","volume":"1213","author":"Brissette","year":"1994","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M058446_bib7","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/S0022-2275(20)33323-X","article-title":"A. Bensadoun, R. F. Hoyt, Jr., H. B. Brewer, Jr., and S. Santamarina-Fojo, Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice","volume":"39","author":"Amar","year":"1998","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib8","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1042\/bj3180841","article-title":"Selective uptake of cholesteryl esters of low-density lipoproteins is mediated by the lipoprotein-binding site in HepG2 cells and is followed by the hydrolysis of cholesteryl esters","volume":"318","author":"Brissette","year":"1996","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M058446_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0021-9150(95)05606-8","article-title":"Influence of lipoprotein lipase and hepatic lipase on the transformation of VLDL and HDL during lipolysis of VLDL","volume":"118","author":"Murdoch","year":"1995","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M058446_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0005-2760(79)90029-8","article-title":"Lipoprotein substrates of lipoprotein lipase and hepatic triacylglycerol lipase from human post-heparin plasma","volume":"575","author":"Musliner","year":"1979","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M058446_bib11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0022-2275(20)42054-1","article-title":"Selective uptake of cholesteryl esters from low density lipoproteins in vitro and in vivo","volume":"32","author":"Green","year":"1991","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib12","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1172\/JCI114112","article-title":"Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody. Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma","volume":"83","author":"Yen","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M058446_bib13","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.ATV.19.3.718","article-title":"Lipid transfer inhibitor protein defines the participation of lipoproteins in lipid transfer reactions: CETP has no preference for cholesteryl esters in HDL versus LDL","volume":"19","author":"Serdyuk","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M058446_bib14","doi-asserted-by":"crossref","unstructured":"Qiu, X., A. Mistry, M. J. Ammirati, B. A. Chrunyk, R. W. Clark, Y. Cong, J. S. Culp, D. E. Danley, T. B. Freeman, K. F. Geoghegan, . 2007. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat. Struct. Mol. Biol. 14: 106\u2013113.","DOI":"10.1038\/nsmb1197"},{"key":"10.1194\/jlr.M058446_bib15","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1016\/S0021-9258(18)32311-1","article-title":"On the mechanism of transfer of cholesterol between human erythrocytes and plasma","volume":"258","author":"Lange","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M058446_bib16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1194\/jlr.M043067","article-title":"Homeostasis of free cholesterol in the blood: a preliminary evaluation and modeling of its passive transport","volume":"55","author":"Estronca","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0026-0495(98)90064-6","article-title":"SAAM II: Simulation, Analysis, and Modeling Software for tracer and pharmacokinetic studies","volume":"47","author":"Barrett","year":"1998","journal-title":"Metabolism."},{"key":"10.1194\/jlr.M058446_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0022-2275(20)32065-4","article-title":"Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions","volume":"41","author":"Packard","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib19","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1194\/jlr.M300511-JLR200","article-title":"Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans","volume":"45","author":"Schwartz","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/meta.2002.29006","article-title":"A new labeling approach using stable isotopes to study in vivo plasma cholesterol metabolism in humans","volume":"51","author":"Ouguerram","year":"2002","journal-title":"Metabolism."},{"key":"10.1194\/jlr.M058446_bib21","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0022-2275(20)40681-9","article-title":"Endogenously labeled low density lipoprotein triglyceride and apoprotein B kinetics","volume":"19","author":"Malmendier","year":"1978","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s001090000156","article-title":"A pathway model of lipid metabolism to predict the effect of genetic variability on lipid levels","volume":"78","author":"Knoblauch","year":"2000","journal-title":"J. Mol. Med."},{"key":"10.1194\/jlr.M058446_bib23","doi-asserted-by":"crossref","first-page":"e1000079","DOI":"10.1371\/journal.pcbi.1000079","article-title":"Computational lipidology: predicting lipoprotein density profiles in human blood plasma","volume":"4","author":"H\u00fcbner","year":"2008","journal-title":"PLOS Comput. Biol."},{"key":"10.1194\/jlr.M058446_bib24","doi-asserted-by":"crossref","unstructured":"van Schalkwijk, D. B., A. A. de Graaf, B. van Ommen, K. van Bochove, P. C. Rensen, L. M. Havekes, N. C. van de Pas, H. C. Hoefsloot, J. van der Greef, and A. P. Freidig. 2009. Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size. J. Lipid Res. 50: 2398\u20132411.","DOI":"10.1194\/jlr.M800354-JLR200"},{"key":"10.1194\/jlr.M058446_bib25","doi-asserted-by":"crossref","first-page":"e1003509","DOI":"10.1371\/journal.pcbi.1003509","article-title":"An in-silico model of lipoprotein metabolism and kinetics for the evaluation of targets and biomarkers in the reverse cholesterol transport pathway","volume":"10","author":"Lu","year":"2014","journal-title":"PLOS Comput. Biol."},{"key":"10.1194\/jlr.M058446_bib26","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.2337\/diacare.26.9.2588","article-title":"Pioglitazone reduces atherogenic dense LDL particles in nondiabetic patients with arterial hypertension: a double-blind, placebo-controlled study","volume":"26","author":"Winkler","year":"2003","journal-title":"Diabetes Care."},{"key":"10.1194\/jlr.M058446_bib27","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1194\/jlr.M900015-JLR200","article-title":"Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro","volume":"50","author":"Potter","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib28","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0022-2275(20)36957-1","article-title":"Plasma cholesteryl ester transfer protein","volume":"34","author":"Tall","year":"1993","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib29","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0022-2275(20)38295-X","article-title":"Measurement of normative HDL subfraction cholesterol levels by Gaussian summation analysis of gradient gels","volume":"30","author":"Verdery","year":"1989","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1073\/pnas.74.3.837","article-title":"Structure of human serum lipoproteins inferred from compositional analysis","volume":"74","author":"Shen","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M058446_bib31","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1194\/jlr.M300521-JLR200","article-title":"Combined data from LDL composition and size measurement are compatible with a discoid particle shape","volume":"45","author":"Teerlink","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0021-9150(01)00709-2","article-title":"Apolipoprotein B metabolism in humans: studies with stable isotope-labeled amino acid precursors","volume":"162","author":"Marsh","year":"2002","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M058446_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/comjnl\/7.4.308","article-title":"A simplex method for function minimization","volume":"7","author":"Nelder","year":"1965","journal-title":"Comput. J."},{"key":"10.1194\/jlr.M058446_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0009-8981(80)90316-2","article-title":"The determination of lecithin:cholesterol acyl transferase in the clinical laboratory: a modified enzymatic procedure","volume":"106","author":"Dieplinger","year":"1980","journal-title":"Clin. Chim. Acta."},{"key":"10.1194\/jlr.M058446_bib35","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/S0022-2275(20)41093-4","article-title":"Neutral lipid mass transfer among lipoproteins in plasma from normolipidemic subjects is not an equimolar heteroexchange","volume":"36","author":"Liu","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib36","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S1357-2725(99)00046-1","article-title":"Low density lipoprotein uptake: holoparticle and cholesteryl ester selective uptake","volume":"31","author":"Rhainds","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1194\/jlr.M058446_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-2275(20)43114-1","article-title":"The plasma lecithins:cholesterol acyltransferase reaction","volume":"9","author":"Glomset","year":"1968","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M058446_bib38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/01.ATV.13.2.147","article-title":"Effect of hepatic lipase on LDL in normal men and those with coronary artery disease","volume":"13","author":"Zambon","year":"1993","journal-title":"Arterioscler. Thromb."},{"key":"10.1194\/jlr.M058446_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2080001","article-title":"Transfers and exchanges of esterified cholesterol between plasma lipoproteins","volume":"208","author":"Barter","year":"1982","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M058446_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1161\/01.ATV.14.2.199","article-title":"A new in vitro method for the simultaneous evaluation of cholesteryl ester exchange and mass transfer between HDL and apoB-containing lipoprotein subspecies. Identification of preferential cholesteryl ester acceptors in human plasma","volume":"14","author":"Gu\u00e9rin","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"10.1194\/jlr.M058446_bib41","doi-asserted-by":"crossref","unstructured":"Millar, J. S., M. E. Brousseau, M. R. Diffenderfer, P. H. Barrett, F. K. Welty, A. Faruqi, M. L. Wolfe, C. Nartsupha, A. G. Digenio, J. P. Mancuso, . 2006. Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans. Arterioscler. Thromb. Vasc. Biol. 26: 1350\u20131356.","DOI":"10.1161\/01.ATV.0000219695.84644.56"},{"key":"10.1194\/jlr.M058446_bib42","doi-asserted-by":"crossref","unstructured":"Krauss, R. M., K. Wojnooski, J. Orr, J. C. Geaney, C. A. Pinto, Y. Liu, J. A. Wagner, J. M. Luk, A. O. Johnson-Levonas, M. S. Anderson, . 2012. Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib. J. Lipid Res. 53: 540\u2013547.","DOI":"10.1194\/jlr.M018010"},{"key":"10.1194\/jlr.M058446_bib43","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/ajcn\/76.2.345","article-title":"Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat","volume":"76","author":"Callow","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1194\/jlr.M058446_bib44","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science."},{"key":"10.1194\/jlr.M058446_bib45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1194\/jlr.M300295-JLR200","article-title":"Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: role of central obesity and LIPC polymorphisms","volume":"45","author":"Carr","year":"2004","journal-title":"J. Lipid Res."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520309901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520309901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M058446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T15:32:09Z","timestamp":1637422329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520309901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0022227520309901"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m058446","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico modeling of the dynamics of low density lipoprotein composition via a single plasma sample","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.M058446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}