{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:18:10Z","timestamp":1787869090058,"version":"build-2784847793"},"reference-count":61,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":1595,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99\/R00 DK077449"],"award-info":[{"award-number":["K99\/R00 DK077449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK099593"],"award-info":[{"award-number":["R01 DK099593"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK47918"],"award-info":[{"award-number":["DK47918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1194\/jlr.m067181","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T04:43:53Z","timestamp":1464842633000},"page":"1219-1230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis"],"prefix":"10.1016","volume":"57","author":[{"given":"Xin","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"VanDommelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyou","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Bishr","family":"Omary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M067181_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3109\/10409238.2011.562481","article-title":"Insulin signaling to hepatic lipid metabolism in health and disease","volume":"46","author":"Leavens","year":"2011","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1194\/jlr.M067181_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0092-8674(01)00239-2","article-title":"New perspectives into the molecular pathogenesis and treatment of type 2 diabetes","volume":"104","author":"Saltiel","year":"2001","journal-title":"Cell."},{"key":"10.1194\/jlr.M067181_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1194\/jlr.M067181_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cmet.2007.11.013","article-title":"Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis","volume":"7","author":"Biddinger","year":"2008","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M067181_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cmet.2009.10.004","article-title":"Akt2 is required for hepatic lipid accumulation in models of insulin resistance","volume":"10","author":"Leavens","year":"2009","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M067181_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molcel.2010.06.022","article-title":"Activation of a metabolic gene regulatory network downstream of mTOR complex 1","volume":"39","author":"D\u00fcvel","year":"2010","journal-title":"Mol. Cell."},{"key":"10.1194\/jlr.M067181_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2008.07.007","article-title":"SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth","volume":"8","author":"Porstmann","year":"2008","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M067181_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI1411","article-title":"Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1\/SREBP1","volume":"101","author":"Kim","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M067181_bib9","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1073\/pnas.95.11.5987","article-title":"Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice","volume":"95","author":"Horton","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/abbs\/gms108","article-title":"SIRT1 and energy metabolism","volume":"45","author":"Li","year":"2013","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)."},{"key":"10.1194\/jlr.M067181_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1748-1716.2009.01970.x","article-title":"AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives","volume":"196","author":"Viollet","year":"2009","journal-title":"Acta Physiol. (Oxf.)."},{"key":"10.1194\/jlr.M067181_bib12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1262-3636(08)74599-3","article-title":"The role of the lipogenic pathway in the development of hepatic steatosis","volume":"34","author":"Postic","year":"2008","journal-title":"Diabetes Metab."},{"issue":"Suppl 2","key":"10.1194\/jlr.M067181_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1463-1326.2010.01275.x","article-title":"Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c","volume":"12","author":"Ferr\u00e9","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1194\/jlr.M067181_bib14","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M067181_bib15","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M067181_bib16","doi-asserted-by":"crossref","first-page":"32379","DOI":"10.1074\/jbc.R000017200","article-title":"Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action","volume":"275","author":"Osborne","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib17","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1073\/pnas.0904246106","article-title":"Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif","volume":"106","author":"Seo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib18","doi-asserted-by":"crossref","first-page":"30028","DOI":"10.1074\/jbc.274.42.30028","article-title":"Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus","volume":"274","author":"Shimomura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1097-2765(05)00010-9","article-title":"Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob\/ob mice","volume":"6","author":"Shimomura","year":"2000","journal-title":"Mol. Cell."},{"key":"10.1194\/jlr.M067181_bib20","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1172\/JCI37007","article-title":"GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice","volume":"119","author":"Kammoun","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M067181_bib21","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1172\/JCI118951","article-title":"Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a","volume":"98","author":"Shimano","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M067181_bib22","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI119248","article-title":"Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells","volume":"99","author":"Shimano","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M067181_bib23","doi-asserted-by":"crossref","first-page":"19353","DOI":"10.1074\/jbc.M201584200","article-title":"Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)\/Lep(ob) mice","volume":"277","author":"Yahagi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib24","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1074\/jbc.M111421200","article-title":"Diminished hepatic response to fasting\/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c","volume":"277","author":"Liang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1073\/pnas.0405067102","article-title":"Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c","volume":"102","author":"Hegarty","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib26","doi-asserted-by":"crossref","first-page":"7518","DOI":"10.1074\/jbc.M805746200","article-title":"Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles","volume":"284","author":"Yellaturu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib27","doi-asserted-by":"crossref","first-page":"31726","DOI":"10.1074\/jbc.M109.050914","article-title":"Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex","volume":"284","author":"Yellaturu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib28","doi-asserted-by":"crossref","first-page":"36431","DOI":"10.1074\/jbc.M105200200","article-title":"Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway","volume":"276","author":"Hirano","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib29","doi-asserted-by":"crossref","first-page":"16809","DOI":"10.1074\/jbc.M212448200","article-title":"Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin\/26 S proteasome pathway","volume":"278","author":"Hirano","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib30","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1128\/MCB.23.7.2587-2599.2003","article-title":"Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors","volume":"23","author":"Giandomenico","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.M067181_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cmet.2005.04.010","article-title":"Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)","volume":"1","author":"Sundqvist","year":"2005","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M067181_bib32","doi-asserted-by":"crossref","first-page":"33959","DOI":"10.1074\/jbc.M110.122978","article-title":"SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism","volume":"285","author":"Ponugoti","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib33","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1101\/gad.1901210","article-title":"Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid\/cholesterol regulator SREBP","volume":"24","author":"Walker","year":"2010","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M067181_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.it.2011.10.002","article-title":"E4BP4: an unexpected player in the immune response","volume":"33","author":"Male","year":"2012","journal-title":"Trends Immunol."},{"key":"10.1194\/jlr.M067181_bib35","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.15190\/d.2014.7","article-title":"New frontiers for the NFIL3 bZIP transcription factor in cancer, metabolism and beyond","volume":"2","author":"Keniry","year":"2014","journal-title":"Discoveries (Craiova)."},{"key":"10.1194\/jlr.M067181_bib36","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gad.873501","article-title":"Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism","volume":"15","author":"Mitsui","year":"2001","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M067181_bib37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ng1504","article-title":"System-level identification of transcriptional circuits underlying mammalian circadian clocks","volume":"37","author":"Ueda","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M067181_bib38","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1210\/en.2012-1820","article-title":"Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells","volume":"154","author":"Carey","year":"2013","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M067181_bib39","doi-asserted-by":"crossref","first-page":"36401","DOI":"10.1074\/jbc.M110.172866","article-title":"Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding","volume":"285","author":"Tong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib40","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1210\/en.2003-1436","article-title":"Parathyroid hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic adenosine 3\u2032,5\u2032-monophosphate signaling in osteoblasts","volume":"145","author":"Ozkurt","year":"2004","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M067181_bib41","doi-asserted-by":"crossref","first-page":"25280","DOI":"10.1074\/jbc.M112.340786","article-title":"USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals","volume":"287","author":"Tong","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib42","doi-asserted-by":"crossref","first-page":"e0130047","DOI":"10.1371\/journal.pone.0130047","article-title":"Palmitate inhibits SIRT1-dependent BMAL1\/CLOCK interaction and disrupts circadian gene oscillations in hepatocytes","volume":"10","author":"Tong","year":"2015","journal-title":"PLoS One."},{"key":"10.1194\/jlr.M067181_bib43","doi-asserted-by":"crossref","first-page":"25925","DOI":"10.1074\/jbc.M114.567628","article-title":"Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling","volume":"289","author":"Zhang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib44","doi-asserted-by":"crossref","first-page":"38128","DOI":"10.1074\/jbc.M111.256677","article-title":"Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid \u03b2-oxidation","volume":"286","author":"Sheng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib45","doi-asserted-by":"crossref","first-page":"12737","DOI":"10.1073\/pnas.96.22.12737","article-title":"Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes","volume":"96","author":"Foretz","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib46","doi-asserted-by":"crossref","first-page":"13656","DOI":"10.1073\/pnas.96.24.13656","article-title":"Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes","volume":"96","author":"Shimomura","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib47","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1073\/pnas.0914798107","article-title":"Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2011.06.002","article-title":"Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways","volume":"14","author":"Yecies","year":"2011","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M067181_bib49","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1053\/j.gastro.2013.01.053","article-title":"Akt and mTORC1 have different roles during liver tumorigenesis in mice","volume":"144","author":"Kenerson","year":"2013","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M067181_bib50","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.18632\/oncotarget.1236","article-title":"The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy","volume":"4","author":"Simioni","year":"2013","journal-title":"Oncotarget."},{"key":"10.1194\/jlr.M067181_bib51","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1073\/pnas.1015959108","article-title":"Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways","volume":"108","author":"Hatori","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib52","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1128\/MCB.15.5.2582","article-title":"Dual DNA binding specificity of ADD1\/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain","volume":"15","author":"Kim","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.M067181_bib53","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.molmet.2014.02.002","article-title":"Integrated physiology and systems biology of PPARalpha","volume":"3","author":"Kersten","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1194\/jlr.M067181_bib54","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/bies.10176","article-title":"E4BP4\/NFIL3, a PAR-related bZIP factor with many roles","volume":"24","author":"Cowell","year":"2002","journal-title":"BioEssays."},{"key":"10.1194\/jlr.M067181_bib55","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1074\/jbc.M112.433482","article-title":"Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein","volume":"288","author":"Tong","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M067181_bib56","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1101\/gad.891301","article-title":"SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation","volume":"15","author":"Matsuda","year":"2001","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M067181_bib57","doi-asserted-by":"crossref","first-page":"11245","DOI":"10.1073\/pnas.0404297101","article-title":"Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver","volume":"101","author":"Chen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M067181_bib58","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1042\/BJ20040162","article-title":"Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements","volume":"385","author":"Cagen","year":"2005","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M067181_bib59","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice","volume":"13","author":"Li","year":"2011","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M067181_bib60","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/hep.27011","article-title":"Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation","volume":"60","author":"Lee","year":"2014","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M067181_bib61","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3109\/00365521.2011.613945","article-title":"Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice","volume":"46","author":"Frederico","year":"2011","journal-title":"Scand. J. Gastroenterol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520351580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520351580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M067181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T18:51:01Z","timestamp":1637434261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520351580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0022227520351580"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m067181","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.M067181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}