{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:55:37Z","timestamp":1792065337464,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":1620,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1194\/jlr.m067942","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T00:12:41Z","timestamp":1461888761000},"page":"1051-1058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Use of lipidomics to investigate sebum dysfunction in juvenile acne"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6633-0449","authenticated-orcid":false,"given":"Emanuela","family":"Camera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-2315","authenticated-orcid":false,"given":"Matteo","family":"Ludovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-8323","authenticated-orcid":false,"given":"Sara","family":"Tortorella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Linda","family":"Sinagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Capitanio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-9013","authenticated-orcid":false,"given":"Laura","family":"Goracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-6639","authenticated-orcid":false,"given":"Mauro","family":"Picardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M067942_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","article-title":"What is the pathogenesis of acne?","volume":"14","author":"Zouboulis","year":"2005","journal-title":"Exp. Dermatol."},{"key":"10.1194\/jlr.M067942_bib2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/jdv.12298","article-title":"Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions","volume":"28","author":"Zouboulis","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1194\/jlr.M067942_bib3","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jaad.2015.08.015","article-title":"Role of sebaceous glands in inflammatory dermatoses","volume":"73","author":"Shi","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1194\/jlr.M067942_bib4","doi-asserted-by":"crossref","first-page":"858176","DOI":"10.1155\/2010\/858176","article-title":"Lipid mediators in acne","volume":"2010","author":"Ottaviani","year":"2010","journal-title":"Mediators Inflamm."},{"key":"10.1194\/jlr.M067942_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/derm.1.2.8472","article-title":"Sebaceous gland lipids","volume":"1","author":"Picardo","year":"2009","journal-title":"Dermatoendocrinol."},{"key":"10.1194\/jlr.M067942_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1046\/j.1523-1747.2003.12321.x","article-title":"Inflammatory events are involved in acne lesion initiation","volume":"121","author":"Jeremy","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1194\/jlr.M067942_bib7","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/1346-8138.12699","article-title":"Fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris","volume":"41","author":"Akaza","year":"2014","journal-title":"J. Dermatol."},{"key":"10.1194\/jlr.M067942_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1684\/ejd.2011.1357","article-title":"Pathways to inflammation: acne pathophysiology","volume":"21","author":"Taylor","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"10.1194\/jlr.M067942_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2133.1970.tb12431.x","article-title":"Sebum excretion and sebum composition in adolescent men with and without acne vulgaris","volume":"82","author":"Powell","year":"1970","journal-title":"Br. J. Dermatol."},{"key":"10.1194\/jlr.M067942_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2133.1971.tb07186.x","article-title":"The relationship between surface lipid composition and acne vulgaris","volume":"85","author":"Cunliffe","year":"1971","journal-title":"Br. J. Dermatol."},{"key":"10.1194\/jlr.M067942_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/1523-1747.ep12482300","article-title":"Octadeca\u00addienoic acids in the skin surface lipids of acne patients and normal subjects","volume":"66","author":"Morello","year":"1976","journal-title":"J. Invest. Dermatol."},{"key":"10.1194\/jlr.M067942_bib12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/1523-1747.ep12511753","article-title":"Skin surface lipid composition, acne, pubertal development, and urinary excretion of testosterone and 17-ketosteroids in children","volume":"69","author":"Pochi","year":"1977","journal-title":"J. Invest. Dermatol."},{"key":"10.1194\/jlr.M067942_bib13","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/1523-1747.ep12543549","article-title":"Skin surface glycerol levels in acne vulgaris","volume":"70","author":"Rebillo","year":"1978","journal-title":"J. Invest. Dermatol."},{"key":"10.1194\/jlr.M067942_bib14","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/1523-1747.ep12276314","article-title":"Characterization of wax esters, triglycerides, and free fatty acids of follicular casts","volume":"86","author":"Nordstrom","year":"1986","journal-title":"J. Invest. Dermatol."},{"key":"10.1194\/jlr.M067942_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.forsciint.2014.02.020","article-title":"Lipid composition of fingermark residue and donor classification using GC\/MS","volume":"238","author":"Girod","year":"2014","journal-title":"Forensic Sci. Int."},{"key":"10.1194\/jlr.M067942_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1194\/jlr.D008094","article-title":"High-temperature gas chromatography-mass spectrometry for skin surface lipids profiling","volume":"52","author":"Michael-Jubeli","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M067942_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1684\/ejd.2011.1263","article-title":"Chemometric approach for investigating the skin surface lipids (SSLs) composition: influence of geographical localization","volume":"21","author":"Michael-Jubeli","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"10.1194\/jlr.M067942_bib18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.gene.2014.10.039","article-title":"Lipidomics in the study of lipid metabolism: current perspectives in the omic sciences","volume":"554","author":"Rolim","year":"2015","journal-title":"Gene."},{"key":"10.1194\/jlr.M067942_bib19","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1194\/jlr.D700035-JLR200","article-title":"Quantitative evaluation of sebum lipid components with nuclear magnetic resonance","volume":"49","author":"Robosky","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M067942_bib20","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1194\/jlr.D008391","article-title":"Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry","volume":"51","author":"Camera","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M067942_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1468-3083.2010.03685.x","article-title":"Development and evaluation of a Global Acne Severity Scale (GEA Scale) suitable for France and Europe","volume":"25","author":"Dr\u00e9no","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1194\/jlr.M067942_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/qsar.19930120103","article-title":"Generating optimal linear PLS estimations (GOLPE): an advanced chemometric tool for handling 3D-QSAR problems","volume":"12","author":"Baroni","year":"1993","journal-title":"Quantitative Structure-Activity Relationships."},{"key":"10.1194\/jlr.M067942_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-7439(01)00155-1","article-title":"PLS-regression: a basic tool of chemometrics","volume":"58","author":"Wold","year":"2001","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.1194\/jlr.M067942_bib24","unstructured":"Eriksson, L., E. Johansson, N. Kettaneh-Wold, and S. Wold, . 1999. Scaling. In Introduction to Multi- and Megavariate Data Analysis using Projection Methods (PCA & PLS). Umetrics, Sweden. 213\u2013225."},{"key":"10.1194\/jlr.M067942_bib25","doi-asserted-by":"crossref","first-page":"D527","DOI":"10.1093\/nar\/gkl838","article-title":"LMSD: LIPID MAPS structure database","volume":"35","author":"Sud","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.M067942_bib26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1194\/jlr.E400004-JLR200","article-title":"A comprehensive classification system for lipids","volume":"46","author":"Fahy","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M067942_bib27","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1194\/jlr.R800095-JLR200","article-title":"Update of the LIPID MAPS comprehensive classification system for lipids","volume":"50","author":"Fahy","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M067942_bib28","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/bjd.12149","article-title":"Epidemiology of acne vulgaris","volume":"168","author":"Bhate","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1194\/jlr.M067942_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4161\/derm.1.3.8473","article-title":"Sebum analysis of individuals with and without acne","volume":"1","author":"Pappas","year":"2009","journal-title":"Dermatoendocrinol."},{"key":"10.1194\/jlr.M067942_bib30","doi-asserted-by":"crossref","unstructured":"Dreno, B., H. P. Gollnick, S. Kang, D. Thiboutot, V. Bettoli, V. Torres, and J. Leyden, ; Global Alliance to Improve Outcomes in Acne. 2015. Understanding innate immunity and inflammation in acne: implications for management. J. Eur. Acad. Dermatol. Venereol. 29: 3\u201311.","DOI":"10.1111\/jdv.13190"},{"key":"10.1194\/jlr.M067942_bib31","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000328731","article-title":"Comparative analysis of skin surface lipids of the labia majora, inner thigh, and forearm","volume":"24","author":"Warren","year":"2011","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1194\/jlr.M067942_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jdermsci.2007.11.005","article-title":"The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides","volume":"50","author":"Smith","year":"2008","journal-title":"J. Dermatol. Sci."},{"key":"10.1194\/jlr.M067942_bib33","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/1523-1747.ep12456327","article-title":"Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects","volume":"90","author":"Perisho","year":"1988","journal-title":"J. Invest. Dermatol."},{"key":"10.1194\/jlr.M067942_bib34","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nm0410-400","article-title":"Diacylglycerol-mediated insulin resistance","volume":"16","author":"Erion","year":"2010","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.M067942_bib35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.advenzreg.2009.01.005","article-title":"Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling","volume":"49","author":"Grkovich","year":"2009","journal-title":"Adv. Enzyme Regul."},{"key":"10.1194\/jlr.M067942_bib36","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2147\/CCID.S69135","article-title":"Linking diet to acne metabolomics, inflammation, and comedogenesis: an update","volume":"8","author":"Melnik","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520351828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520351828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M067942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T18:52:45Z","timestamp":1637434365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520351828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0022227520351828"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m067942","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of lipidomics to investigate sebum dysfunction in juvenile acne","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.M067942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}