{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:37:23Z","timestamp":1790789843493,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":1322,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["DK77573"],"award-info":[{"award-number":["DK77573"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010288","name":"Wright State University","doi-asserted-by":"publisher","award":["P116M100027"],"award-info":[{"award-number":["P116M100027"]}],"id":[{"id":"10.13039\/100010288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010288","name":"Additional support was provided, in part, by the U.S. Department of Education Fund for the Improvement of Postsecondary Education","doi-asserted-by":"publisher","award":["P116M100027"],"award-info":[{"award-number":["P116M100027"]}],"id":[{"id":"10.13039\/100010288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM086257"],"award-info":[{"award-number":["GM086257"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL10316"],"award-info":[{"award-number":["HL10316"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1194\/jlr.m072447","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T03:00:35Z","timestamp":1482548435000},"page":"393-402","update-policy":"https:\/\/doi.org\/10.1194\/jlr.f110.005975","source":"Crossref","is-referenced-by-count":23,"title":["Fatty acid binding profile of the liver X receptor \u03b1"],"prefix":"10.1016","volume":"58","author":[{"given":"Shimpi","family":"Bedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genesis Victoria","family":"Hines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery V.","family":"Lozada-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"de Jesus Piva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alagammai","family":"Kaliappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"S.Dean","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Hostetler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M072447_bib1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/383728a0","article-title":"An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha","volume":"383","author":"Janowski","year":"1996","journal-title":"Nature."},{"key":"10.1194\/jlr.M072447_bib2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1074-5521(96)90143-X","article-title":"Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses","volume":"3","author":"Katzenellenbogen","year":"1996","journal-title":"Chem. Biol."},{"key":"10.1194\/jlr.M072447_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gad.11.3.299","article-title":"The phantom ligand effect: allosteric control of transcription by the retinoid X receptor","volume":"11","author":"Schulman","year":"1997","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M072447_bib4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1101\/gad.9.9.1033","article-title":"LXR, a nuclear receptor that defines a distinct retinoid response pathway","volume":"9","author":"Willy","year":"1995","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M072447_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1073\/pnas.96.1.266","article-title":"Structural requirements of ligands for the oxysterol liver X receptors LXR alpha and LXR beta","volume":"96","author":"Janowski","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M072447_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3945\/an.111.001602","article-title":"Mechanisms of gene regulation by fatty acids","volume":"3","author":"Georgiadi","year":"2012","journal-title":"Adv. Nutr."},{"key":"10.1194\/jlr.M072447_bib7","doi-asserted-by":"crossref","first-page":"37735","DOI":"10.1074\/jbc.R100035200","article-title":"Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism","volume":"276","author":"Lu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M072447_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2174\/156802612799436641","article-title":"General molecular biology and architecture of nuclear receptors","volume":"12","author":"Pawlak","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1194\/jlr.M072447_bib9","doi-asserted-by":"crossref","first-page":"e005","DOI":"10.1621\/nrs.07005","article-title":"Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)","volume":"7","author":"Rochette-Egly","year":"2009","journal-title":"Nucl. Recept. Signal."},{"key":"10.1194\/jlr.M072447_bib10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.cellbio.16.1.459","article-title":"The role of orphan nuclear receptors in the regulation of cholesterol homeostasis","volume":"16","author":"Repa","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1194\/jlr.M072447_bib11","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1172\/JCI59817","article-title":"Liver LXR\u03b1 expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice","volume":"122","author":"Zhang","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M072447_bib12","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)81432-4","article-title":"Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha","volume":"93","author":"Peet","year":"1998","journal-title":"Cell."},{"key":"10.1194\/jlr.M072447_bib13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1172\/JCI9794","article-title":"Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta deficient mice","volume":"107","author":"Alberti","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M072447_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/CS20100387","article-title":"Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C","volume":"120","author":"Lima-Cabello","year":"2011","journal-title":"Clin. Sci."},{"key":"10.1194\/jlr.M072447_bib15","first-page":"507","article-title":"SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease","volume":"21","author":"Kohjima","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1194\/jlr.M072447_bib16","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/j.1872-034X.2008.00382.x","article-title":"Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease.","volume":"38","author":"Higuchi","year":"2008","journal-title":"Hepatol. Res."},{"key":"10.1194\/jlr.M072447_bib17","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1073\/pnas.112059299","article-title":"Synthetic LXR ligand inhibits the development of atherosclerosis in mice","volume":"99","author":"Joseph","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M072447_bib18","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.addr.2010.07.002","article-title":"Nuclear receptors as drug targets for metabolic disease","volume":"62","author":"Schulman","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1194\/jlr.M072447_bib19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s00125-015-3827-x","article-title":"LXR\u03b1 improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes","volume":"59","author":"Cannon","year":"2016","journal-title":"Diabetologia."},{"key":"10.1194\/jlr.M072447_bib20","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1074\/jbc.M105711200","article-title":"Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements","volume":"277","author":"Yoshikawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M072447_bib21","doi-asserted-by":"crossref","first-page":"40736","DOI":"10.1074\/jbc.M307973200","article-title":"The role of liver X receptor- \u03b1 in the fatty acid regulation of hepatic gene expression","volume":"278","author":"Pawar","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M072447_bib22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.nutr.25.051804.101917","article-title":"Polyunsaturated fatty acid regulation of genes of lipid metabolism","volume":"25","author":"Sampath","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"10.1194\/jlr.M072447_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.plefa.2010.02.016","article-title":"Regulation of hepatic gene expression by saturated fatty acids","volume":"82","author":"Vallim","year":"2010","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids."},{"key":"10.1194\/jlr.M072447_bib24","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1110\/ps.04951405","article-title":"Ligand-binding regulation of LXR\/RXR and LXR\/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamic simulation","volume":"14","author":"Yue","year":"2005","journal-title":"Protein Sci."},{"key":"10.1194\/jlr.M072447_bib25","doi-asserted-by":"crossref","first-page":"18667","DOI":"10.1074\/jbc.M412062200","article-title":"Peroxisome proliferator-activated receptor alpha interacts with high affinity and is conformationally responsive to endogenous ligands","volume":"280","author":"Hostetler","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M072447_bib26","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1073\/pnas.111138698","article-title":"Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR","volume":"98","author":"Ou","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M072447_bib27","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1021\/bi401679y","article-title":"Ligand-regulated heterodimerization of peroxisome proliferator-activated receptor \u03b1 with liver X receptor \u03b1","volume":"53","author":"Balanarasimha","year":"2014","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.M072447_bib28","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1194\/jlr.M035436","article-title":"Divergence between human and murine peroxisome proliferator-activated receptor alpha ligand specificities","volume":"54","author":"Oswal","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M072447_bib29","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1074\/jbc.M705138200","article-title":"Glucose directly links to lipid metabolism through high affinity interaction with peroxisome proliferator-activated receptor alpha","volume":"283","author":"Hostetler","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M072447_bib30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/abio.2000.4880","article-title":"Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set","volume":"287","author":"Sreerama","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1194\/jlr.M072447_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jmgm.2014.04.006","article-title":"A single amino acid changes humanizes long-chain fatty acid binding and activation of mouse peroxisome proliferator-activated receptor \u03b1","volume":"51","author":"Oswal","year":"2014","journal-title":"J. Mol. Graph. Model."},{"key":"10.1194\/jlr.M072447_bib32","doi-asserted-by":"crossref","first-page":"21466","DOI":"10.1074\/jbc.M110.209973","article-title":"Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1)","volume":"286","author":"Fern\u00e1ndez-Alvarez","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M072447_bib33","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1093\/emboj\/cdg456","article-title":"Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation","volume":"22","author":"Svensson","year":"2003","journal-title":"EMBO J."},{"key":"10.1194\/jlr.M072447_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature05449","article-title":"The nuclear receptor LXR is a glucose sensor","volume":"445","author":"Mitro","year":"2007","journal-title":"Nature."},{"key":"10.1194\/jlr.M072447_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02531094","article-title":"Free fatty acids in cultured cells","volume":"5","author":"Howard","year":"1970","journal-title":"Lipids."},{"key":"10.1194\/jlr.M072447_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbamem.2013.09.005","article-title":"Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors","volume":"1838","author":"Sridharan","year":"2014","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M072447_bib37","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1074\/jbc.M007273200","article-title":"Unsaturated fatty acids down-regulate SREBP isoforms 1 a and 1 c by two mechanisms in HEK-293 cells","volume":"276","author":"Hannah","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M072447_bib38","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1021\/bi060198l","article-title":"Very-long-chain and branches-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha)","volume":"45","author":"Hostetler","year":"2006","journal-title":"Biochemistry."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520314206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520314206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M072447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T15:52:24Z","timestamp":1637423544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520314206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0022227520314206"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m072447","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}