{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:26:36Z","timestamp":1783031196895,"version":"3.54.6"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":1144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["2P01 HL-30568"],"award-info":[{"award-number":["2P01 HL-30568"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1194\/jlr.m076554","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:50:21Z","timestamp":1496883021000},"page":"1636-1647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-\u03b2 and cholesterol 25-hydroxylase in jejunum"],"prefix":"10.1016","volume":"58","author":[{"given":"Pallavi","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Hough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Navab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Fogelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Meriwether","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Bensinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Moller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kym F.","family":"Faull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldons J.","family":"Lusis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Luisa","family":"Iruela-Arispe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina I.","family":"Bostrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Tontonoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa T.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Fogelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M076554_bib1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/hc0302.103711","article-title":"Oral administration of an apo A-I mimetic peptide synthesized from D-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol","volume":"105","author":"Navab","year":"2002","journal-title":"Circulation."},{"key":"10.1194\/jlr.M076554_bib2","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1161\/01.CIR.0000134275.90823.87","article-title":"Oral D-4F causes formation of pre-beta high-density lipoprotein and improves high-density lipoprotein mediated cholesterol efflux and reverse cholesterol transport from macrophages in apolipoprotein E-null mice","volume":"109","author":"Navab","year":"2004","journal-title":"Circulation."},{"key":"10.1194\/jlr.M076554_bib3","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/01.ATV.0000167412.98221.1a","article-title":"D-4F and statins synergize to render HDL anti-inflammatory in mice and monkeys and cause lesion regression in old apolipoprotein E-null mice","volume":"25","author":"Navab","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M076554_bib4","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1194\/jlr.M700138-JLR200","article-title":"Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits","volume":"48","author":"Van Lenten","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib5","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1194\/jlr.P800003-JLR200","article-title":"Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients","volume":"49","author":"Bloedon","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1194\/jlr.M011098","article-title":"Treatment of patients with cardiovascular disease with L-4F an apoA-1 mimetic, did not improve select markers of HDL function","volume":"52","author":"Watson","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib7","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1194\/jlr.M013144","article-title":"Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally","volume":"52","author":"Navab","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1194\/jlr.M023523","article-title":"D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice","volume":"53","author":"Navab","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib9","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1194\/jlr.M067025","article-title":"Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux","volume":"57","author":"Meriwether","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1194\/jlr.M033555","article-title":"A novel approach to oral apoA-I mimetic therapy","volume":"54","author":"Chattopadhyay","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib11","doi-asserted-by":"crossref","first-page":"e0152207","DOI":"10.1371\/journal.pone.0152207","article-title":"Ezetimibe promotes brush border membrane-to-lumen cholesterol efflux in the small intestine","volume":"11","author":"Nakano","year":"2016","journal-title":"PLoS One."},{"key":"10.1194\/jlr.M076554_bib12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cmet.2008.05.001","article-title":"Ezetimibe blocks internalization of the NPC1L1\/cholesterol complex","volume":"7","author":"Chang","year":"2008","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M076554_bib13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cmet.2016.10.001","article-title":"Transintestinal cholesterol transport is active in mice and humans and controls ezetimibe-induced fecal neutral sterol excretion","volume":"24","author":"Jakulj","year":"2016","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M076554_bib14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1194\/jlr.M064352","article-title":"Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD","volume":"57","author":"Chattopadhyay","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib15","doi-asserted-by":"crossref","first-page":"e00154","DOI":"10.1002\/prp2.154","article-title":"Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer","volume":"3","author":"Chattopadhyay","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1194\/jlr.M076554_bib16","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1194\/jlr.M042051","article-title":"Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid","volume":"54","author":"Navab","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib17","unstructured":"Merck\/Schering-Plough Pharmaceuticals. 2007. Zetia (Ezetimibe) tablets. Publication 29480958T REV 14. Accessed Jun 23, 2017, at www.accessdata.fda.gov\/drugsatfda_docs\/label\/2008\/021445s019lbl.pdf."},{"key":"10.1194\/jlr.M076554_bib18","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/hq1201.100260","article-title":"Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in apoE knockout mice","volume":"21","author":"Davis","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M076554_bib19","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.1093131","article-title":"Niemann-pick C1 Like 1 protein is critical for intestinal cholesterol absorption","volume":"303","author":"Altmann","year":"2004","journal-title":"Science."},{"key":"10.1194\/jlr.M076554_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2012.11.005","article-title":"Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol","volume":"38","author":"Liu","year":"2013","journal-title":"Immunity."},{"key":"10.1194\/jlr.M076554_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1194\/jlr.M056614","article-title":"Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis","volume":"56","author":"Navab","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M076554_bib22","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nri3755","article-title":"25-Hydroxycholesterols in innate and adaptive immunity","volume":"14","author":"Cyster","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1194\/jlr.M076554_bib23","doi-asserted-by":"crossref","first-page":"e0136629","DOI":"10.1371\/journal.pone.0136629","article-title":"Type I interferons function as autocrine and paracrine factors to induce autotaxin in response to TLR activation","volume":"10","author":"Song","year":"2015","journal-title":"PLoS One."},{"key":"10.1194\/jlr.M076554_bib24","doi-asserted-by":"crossref","first-page":"e47713","DOI":"10.1371\/journal.pone.0047713","article-title":"High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One."},{"key":"10.1194\/jlr.M076554_bib25","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1053\/j.gastro.2012.01.034","article-title":"A high-fat diet is associated with endotoxemia that originates from the gut","volume":"142","author":"Pendyala","year":"2012","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M076554_bib26","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1271\/bbb.56.1465","article-title":"Stimulation of interferon \u03b2 production of cultured cells by phospholipids in foodstuffs","volume":"56","author":"Tahara","year":"1992","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1194\/jlr.M076554_bib27","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1189\/jlb.0610318","article-title":"Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons","volume":"88","author":"Park","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1194\/jlr.M076554_bib28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tem.2012.10.004","article-title":"Atherosclerosis: lessons from LXR and the intestine","volume":"24","author":"Bonamassa","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1194\/jlr.M076554_bib29","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/MOL.0000000000000334","article-title":"Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease","volume":"27","author":"Hui","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1194\/jlr.M076554_bib30","doi-asserted-by":"crossref","first-page":"42906","DOI":"10.1038\/srep42906","article-title":"Ambient ultrafine particle ingestion alters gut microbiota in association with increased atherogenic lipid metabolites","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1194\/jlr.M076554_bib31","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1038\/srep10512","article-title":"Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice","volume":"5","author":"Zhong","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520337895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520337895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M076554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T17:45:58Z","timestamp":1637430358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520337895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0022227520337895"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m076554","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-\u03b2 and cholesterol 25-hydroxylase in jejunum","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.M076554","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}