{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:53:12Z","timestamp":1761393192441},"reference-count":24,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":5900,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1194\/jlr.m400064-jlr200","type":"journal-article","created":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T22:38:10Z","timestamp":1086734290000},"page":"1341-1346","source":"Crossref","is-referenced-by-count":24,"title":["\u03c9-Hydroxylation of phytanic acid in rat liver microsomes"],"prefix":"10.1016","volume":"45","author":[{"given":"J.C.","family":"Komen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.A.","family":"Wanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M400064-JLR200_bib1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1042\/bst0290250","article-title":"Peroxisomal fatty acid alpha- and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases","volume":"29","author":"Wanders","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1194\/jlr.M400064-JLR200_bib2","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"3303","article-title":"Refsum disease","author":"Wanders","year":"2001"},{"key":"10.1194\/jlr.M400064-JLR200_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0163-7827(03)00016-X","article-title":"The chemical biology of branched-chain lipid metabolism","volume":"42","author":"Mukherji","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"10.1194\/jlr.M400064-JLR200_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.0022-3042.2002.00766.x","article-title":"Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation","volume":"80","author":"Wierzbicki","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.M400064-JLR200_bib5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ng1097-190","article-title":"Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene","volume":"17","author":"Jansen","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M400064-JLR200_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199707103370215","article-title":"Phytanoyl-coenzyme A hydroxylase deficiency\u2014the enzyme defect in Refsum's disease","volume":"337","author":"Jansen","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M400064-JLR200_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/ng1097-185","article-title":"Identification of PAHX, a Refsum disease gene","volume":"17","author":"Mihalik","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M400064-JLR200_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/1389200013338423","article-title":"Cytochrome P450 4A fatty acid omega hydroxylases","volume":"2","author":"Okita","year":"2001","journal-title":"Curr. Drug Metab."},{"key":"10.1194\/jlr.M400064-JLR200_bib9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0306-3623(96)00246-7","article-title":"The cytochrome P450 4 (CYP4) family","volume":"28","author":"Simpson","year":"1997","journal-title":"Gen. Pharmacol."},{"key":"10.1194\/jlr.M400064-JLR200_bib10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/00365516809166493","article-title":"The in vitro omega-oxidation of phytanic acid and other branched chain fatty acids by mammalian liver","volume":"22","author":"Try","year":"1968","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1194\/jlr.M400064-JLR200_bib11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0140-6736(82)90760-7","article-title":"Metabolism of phytanic acid in Refsum's disease","volume":"1","author":"Billimoria","year":"1982","journal-title":"Lancet."},{"key":"10.1194\/jlr.M400064-JLR200_bib12","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0140-6736(82)91780-9","article-title":"3-Methyladipate excretion in Refsum's disease","volume":"319","author":"Brenton","year":"1982","journal-title":"Lancet."},{"key":"10.1194\/jlr.M400064-JLR200_bib13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/clinchem\/29.3.434","article-title":"2,6-Dimethyloctanedioic acid\u2014a metabolite of phytanic acid in Refsum's disease","volume":"29","author":"Greter","year":"1983","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.M400064-JLR200_bib14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1194\/jlr.M300121-JLR200","article-title":"Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease","volume":"44","author":"Wierzbicki","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M400064-JLR200_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/bj0920179","article-title":"Tissue fractionation studies. 17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, D-amino acid oxidase and catalase in rat-liver tissue","volume":"92","author":"Baudhuin","year":"1964","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M400064-JLR200_bib16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1194\/jlr.M400064-JLR200_bib17","series-title":"Organic Acids in Man: The Analytical Chemistry, Biochemistry and Diagnosis of the Organic Acidurias","author":"Chalmers","year":"1982"},{"key":"10.1194\/jlr.M400064-JLR200_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0009-8981(81)90184-4","article-title":"Urinary excretion of gamma-hydroxybutyric acid in a patient with neurological abnormalities. The probability of a new inborn error of metabolism","volume":"111","author":"Jakobs","year":"1981","journal-title":"Clin. Chim. Acta."},{"key":"10.1194\/jlr.M400064-JLR200_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/bms.1200070203","article-title":"Profiles in altered metabolism. II. (Omega-1)-hydroxyacid excretion in a case of episodic hypoglycemia","volume":"7","author":"Mamer","year":"1980","journal-title":"Biomed. Mass Spectrom."},{"key":"10.1194\/jlr.M400064-JLR200_bib20","doi-asserted-by":"crossref","first-page":"13021","DOI":"10.1016\/S0021-9258(18)90650-2","article-title":"Phytanic acid alpha-oxidation in rat liver. Requirement of cytosolic factor","volume":"259","author":"Muralidharan","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M400064-JLR200_bib21","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0022-2275(20)37973-6","article-title":"Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds","volume":"24","author":"Singh","year":"1983","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M400064-JLR200_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.pa.35.040195.000333","article-title":"Structural basis of selective cytochrome P450 inhibition","volume":"35","author":"Halpert","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1194\/jlr.M400064-JLR200_bib23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1124\/dmd.30.3.314","article-title":"Inhibition of cytochromes P450 by antifungal imidazole derivatives","volume":"30","author":"Zhang","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1194\/jlr.M400064-JLR200_bib24","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1096\/fasebj.6.2.1371482","article-title":"Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture","volume":"6","author":"Maurice","year":"1992","journal-title":"FASEB J."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520317909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520317909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M400064-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T16:07:06Z","timestamp":1637424426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520317909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0022227520317909"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m400064-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}