{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:26:33Z","timestamp":1790979993472,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":5266,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1194\/jlr.m500553-jlr200","type":"journal-article","created":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T02:18:50Z","timestamp":1138241930000},"page":"745-754","source":"Crossref","is-referenced-by-count":108,"title":["Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity"],"prefix":"10.1016","volume":"47","author":[{"given":"Laurent","family":"Vergnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne P.","family":"Beigneux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Reue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M500553-JLR200_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S1043-2760(03)00078-X","article-title":"Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways","volume":"14","author":"Agarwal","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1194\/jlr.M500553-JLR200_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0163-7827(03)00051-1","article-title":"Enzymes of triacylglycerol synthesis and their regulation","volume":"43","author":"Coleman","year":"2004","journal-title":"Prog. Lipid Res."},{"key":"10.1194\/jlr.M500553-JLR200_bib3","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1128\/MCB.22.23.8204-8214.2002","article-title":"Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition","volume":"22","author":"Hammond","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.M500553-JLR200_bib4","first-page":"87","article-title":"Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat","volume":"25","author":"Smith","year":"2000","journal-title":"Nature."},{"key":"10.1194\/jlr.M500553-JLR200_bib5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI0214672","article-title":"Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1","volume":"109","author":"Chen","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M500553-JLR200_bib6","doi-asserted-by":"crossref","first-page":"E213","DOI":"10.1152\/ajpendo.00248.2002","article-title":"Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1","volume":"284","author":"Chen","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1194\/jlr.M500553-JLR200_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI0213880","article-title":"Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands","volume":"109","author":"Chen","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M500553-JLR200_bib8","doi-asserted-by":"crossref","first-page":"11767","DOI":"10.1074\/jbc.M311000200","article-title":"Lipopenia and skin barrier abnormalities in DGAT2-deficient mice","volume":"279","author":"Stone","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M500553-JLR200_bib9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1194\/jlr.M500556-JLR200","article-title":"Agpat6\u2014a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium","volume":"47","author":"Beigneux","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M500553-JLR200_bib10","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1074\/jbc.273.7.4096","article-title":"Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex","volume":"273","author":"Aguado","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M500553-JLR200_bib11","doi-asserted-by":"crossref","first-page":"20299","DOI":"10.1074\/jbc.272.32.20299","article-title":"Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3","volume":"272","author":"Eberhardt","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M500553-JLR200_bib12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1101\/gr.193702","article-title":"Exploration of novel motifs derived from mouse cDNA sequences","volume":"12","author":"Kawaji","year":"2002","journal-title":"Genome Res."},{"key":"10.1194\/jlr.M500553-JLR200_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s10038-003-0045-z","article-title":"Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family","volume":"48","author":"Li","year":"2003","journal-title":"J. Hum. Genet."},{"key":"10.1194\/jlr.M500553-JLR200_bib14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/10425170500213712","article-title":"Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7","volume":"16","author":"Ye","year":"2005","journal-title":"DNA Seq."},{"key":"10.1194\/jlr.M500553-JLR200_bib15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1042\/BJ20041348","article-title":"Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart","volume":"385","author":"Lu","year":"2005","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M500553-JLR200_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"Agarwal","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M500553-JLR200_bib17","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2337\/diabetes.52.6.1573","article-title":"Prevalence of mutations in AGPAT2 among human lipodystrophies","volume":"52","author":"Magre","year":"2003","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M500553-JLR200_bib18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/nar\/gkg064","article-title":"BayGenomics: a resource of insertional mutations in mouse embryonic stem cells","volume":"31","author":"Stryke","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.M500553-JLR200_bib19","doi-asserted-by":"crossref","first-page":"29558","DOI":"10.1074\/jbc.M403506200","article-title":"Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro","volume":"279","author":"Phan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M500553-JLR200_bib20","doi-asserted-by":"crossref","first-page":"0034.1","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1194\/jlr.M500553-JLR200_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmet.2004.12.002","article-title":"Lipin, a lipodystrophy and obesity gene","volume":"1","author":"Phan","year":"2005","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M500553-JLR200_bib22","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1074\/jbc.M503885200","article-title":"Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis","volume":"280","author":"Peterfy","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M500553-JLR200_bib23","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1074\/jbc.M310512200","article-title":"ATP-citrate lyase deficiency in the mouse","volume":"279","author":"Beigneux","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M500553-JLR200_bib24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M500553-JLR200_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11745-001-0714-8","article-title":"Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids","volume":"36","author":"Watkins","year":"2001","journal-title":"Lipids."},{"key":"10.1194\/jlr.M500553-JLR200_bib26","doi-asserted-by":"crossref","first-page":"D944","DOI":"10.2741\/Leung","article-title":"The structure and functions of human lysophosphatidic acid acyltransferases","volume":"6","author":"Leung","year":"2001","journal-title":"Front. Biosci."},{"key":"10.1194\/jlr.M500553-JLR200_bib27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.ATV.0000151874.81059.ad","article-title":"Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice","volume":"25","author":"Chen","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M500553-JLR200_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1172\/JCI791","article-title":"Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1","volume":"101","author":"Jong","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M500553-JLR200_bib29","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1083\/jcb.200207080","article-title":"Mice with targeted disruption of the fatty acid transport protein 4 (Fatp4, Slc274a) gene show features of lethal restrictive dermopathy","volume":"161","author":"Herrmann","year":"2003","journal-title":"J. Cell Biol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520332703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520332703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M500553-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T17:19:01Z","timestamp":1637428741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520332703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0022227520332703"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m500553-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}