{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:20:50Z","timestamp":1791084050657,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":4959,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1194\/jlr.m600529-jlr200","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T05:52:55Z","timestamp":1169704375000},"page":"944-951","source":"Crossref","is-referenced-by-count":129,"title":["Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7\u03b1-hydroxy-3-oxo-4-cholestenoic acid"],"prefix":"10.1016","volume":"48","author":[{"given":"Steve","family":"Meaney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Heverin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Panzenboeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Axelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Diczfalusy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Pikuleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wahren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Sattler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar","family":"Bj\u00f6rkhem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M600529-JLR200_bib1","first-page":"1375","volume":"45","author":"Dietschy","year":"2004","journal-title":"Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res."},{"key":"10.1194\/jlr.M600529-JLR200_bib2","first-page":"806","volume":"24","author":"Bj\u00f6rkhem","year":"2004","journal-title":"Brain cholesterol: long secret life behind a barrier. Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M600529-JLR200_bib3","first-page":"1047","volume":"46","author":"Heverin","year":"2005","journal-title":"Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. J. Lipid Res."},{"key":"10.1194\/jlr.M600529-JLR200_bib4","first-page":"793","volume":"44","author":"Leoni","year":"2003","journal-title":"Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. J. Lipid Res."},{"key":"10.1194\/jlr.M600529-JLR200_bib5","first-page":"186","volume":"45","author":"Heverin","year":"2004","journal-title":"Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J. Lipid Res."},{"key":"10.1194\/jlr.M600529-JLR200_bib6","author":"Bj\u00f6rkhem","year":"2001","journal-title":"The Metabolic and Molecular Bases of Inherited Disease. 8th edition. McGraw Hill, New York."},{"key":"10.1194\/jlr.M600529-JLR200_bib7","first-page":"629","volume":"29","author":"Axelson","year":"1988","journal-title":"Occurrence of 3\u03b2-hydroxy-5-cholestenoic acid, 3\u03b2,7\u03b1-dihydroxy-5-cholestenoic acid, and 7\u03b1-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood. J. Lipid Res."},{"key":"10.1194\/jlr.M600529-JLR200_bib8","first-page":"175","volume":"322","author":"Zhang","year":"1997","journal-title":"Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. Biochem. J."},{"key":"10.1194\/jlr.M600529-JLR200_bib9","first-page":"229","volume":"1126","author":"Nagata","year":"1992","journal-title":"Identification of 7\u03b1-hydroxy-3-oxo-4-cholestenoic acid in chronic subdural hematoma. Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M600529-JLR200_bib10","first-page":"294","volume":"35","author":"Nagata","year":"1995","journal-title":"Changes in the level of 7\u03b1-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid after subarachnoid hemorrhage. Neurol. Med. Chir. (Tokyo)."},{"key":"10.1194\/jlr.M600529-JLR200_bib11","first-page":"337","volume":"8","author":"Bj\u00f6rkhem","year":"1969","journal-title":"On the mechanism of the enzymatic conversion of cholest-5-ene-3-\u03b2,7-\u03b1-diol into 7-\u03b1-hydroxycholest-4-en-3-one. Eur. J. Biochem."},{"key":"10.1194\/jlr.M600529-JLR200_bib12","first-page":"105","volume":"195","author":"Janabi","year":"1995","journal-title":"Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen. Neurosci. Lett."},{"key":"10.1194\/jlr.M600529-JLR200_bib13","first-page":"715","volume":"47","author":"Balmforth","year":"1986","journal-title":"D-1 dopaminergic and beta-adrenergic stimulation of adenylate cyclase in a clone derived from the human astrocytoma cell line G-CCM. J. Neurochem."},{"key":"10.1194\/jlr.M600529-JLR200_bib14","first-page":"939","volume":"89","author":"Balazs","year":"2004","journal-title":"Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model. J. Neurochem."},{"key":"10.1194\/jlr.M600529-JLR200_bib15","first-page":"41","volume":"98","author":"Jellinck","year":"2006","journal-title":"Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography\/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia. J. Steroid Biochem. Mol. Biol."},{"key":"10.1194\/jlr.M600529-JLR200_bib16","first-page":"713","volume":"83","author":"Steckelbroeck","year":"2002","journal-title":"Characterization of the dehydroepiandrosterone (DHEA) metabolism via oxysterol 7\u03b1-hydroxylase and 17-ketosteroid reductase activity in the human brain. J. Neurochem."},{"key":"10.1194\/jlr.M600529-JLR200_bib17","first-page":"41","volume":"159","author":"Trap","year":"2005","journal-title":"Immunohistochemical detection of the human cytochrome P4507B1: production of a monoclonal antibody after cDNA immunization. J. Neuroimmunol."},{"key":"10.1194\/jlr.M600529-JLR200_bib18","first-page":"333","volume":"1392","author":"Babiker","year":"1998","journal-title":"Transport of side-chain oxidized oxysterols in the human circulation. Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M600529-JLR200_bib19","first-page":"30178","volume":"272","author":"Bjorkhem","year":"1997","journal-title":"Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. J. Biol. Chem."},{"key":"10.1194\/jlr.M600529-JLR200_bib20","first-page":"22980","volume":"278","author":"Lund","year":"2003","journal-title":"Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem."},{"key":"10.1194\/jlr.M600529-JLR200_bib21","first-page":"208","volume":"16","author":"Lund","year":"1996","journal-title":"Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans. Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M600529-JLR200_bib22","first-page":"34674","volume":"279","author":"Brown","year":"2004","journal-title":"Differential expression of cholesterol hydroxylases in Alzheimer's disease. J. Biol. Chem."},{"key":"10.1194\/jlr.M600529-JLR200_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-0404.2006.00684.x","volume":"185","author":"Bjorkhem","year":"2006","journal-title":"Oxysterols and Alzheimer's disease. Acta Neurol. Scand. Suppl."},{"key":"10.1194\/jlr.M600529-JLR200_bib24","first-page":"307","volume":"121","author":"Yau","year":"2003","journal-title":"Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease. Neuroscience."},{"key":"10.1194\/jlr.M600529-JLR200_bib25","first-page":"3","volume":"71","author":"Schumacher","year":"2003","journal-title":"Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Prog. Neurobiol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520434479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520434479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M600529-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T23:52:52Z","timestamp":1637452372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520434479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0022227520434479"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m600529-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}