{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:35:13Z","timestamp":1793900113634,"version":"4.8.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":4551,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1194\/jlr.m800042-jlr200","type":"journal-article","created":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T02:28:29Z","timestamp":1201573709000},"page":"1068-1076","source":"Crossref","is-referenced-by-count":407,"title":["Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet"],"prefix":"10.1016","volume":"49","author":[{"given":"Mary E.","family":"Rinella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin R.","family":"Smolak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayme","family":"Borensztajn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M800042-JLR200_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0168-8278(01)00094-0","article-title":"Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology","volume":"35","author":"Skelly","year":"2001","journal-title":"J. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/hep.510290347","article-title":"Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease","volume":"29","author":"Caldwell","year":"1999","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M800042-JLR200_bib3","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.transproceed.2003.10.059","article-title":"Outcomes of liver transplantation for cryptogenic cirrhosis: a single-center study of 71 patients","volume":"35","author":"Sanjeevi","year":"2003","journal-title":"Transplant. Proc."},{"key":"10.1194\/jlr.M800042-JLR200_bib4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncpgasthep0084","article-title":"Mechanisms of disease. Pathogenesis of nonalcoholic fatty liver disease","volume":"2","author":"Sanyal","year":"2005","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib5","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/gast.2001.23256","article-title":"Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities","volume":"120","author":"Sanyal","year":"2001","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M800042-JLR200_bib6","doi-asserted-by":"crossref","first-page":"32345","DOI":"10.1074\/jbc.M313478200","article-title":"Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease","volume":"279","author":"Samuel","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800042-JLR200_bib7","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M800042-JLR200_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0168-8278(02)00102-2","article-title":"Leptin is essential for the hepatic fibrogenic response to chronic liver injury","volume":"37","author":"Leclercq","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.20965","article-title":"Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells","volume":"42","author":"Aleffi","year":"2005","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M800042-JLR200_bib10","doi-asserted-by":"crossref","first-page":"G264","DOI":"10.1152\/ajpgi.00002.2004","article-title":"Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model","volume":"287","author":"Sahai","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1194\/jlr.M800042-JLR200_bib11","doi-asserted-by":"crossref","first-page":"G1035","DOI":"10.1152\/ajpgi.00199.2004","article-title":"Obese and diabetic db\/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin","volume":"287","author":"Sahai","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1194\/jlr.M800042-JLR200_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jhep.2003.09.020","article-title":"The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance","volume":"40","author":"Rinella","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib13","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/hep.20170","article-title":"Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice","volume":"39","author":"Ip","year":"2004","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M800042-JLR200_bib14","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/hep.21655","article-title":"Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis","volume":"45","author":"Yamaguchi","year":"2007","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M800042-JLR200_bib15","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1016\/S0021-9258(18)69166-5","article-title":"The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes","volume":"263","author":"Yao","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800042-JLR200_bib16","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1139\/o85-108","article-title":"The role of phosphatidylcholine biosynthesis in the secretion of lipoproteins from hepatocytes","volume":"63","author":"Vance","year":"1985","journal-title":"Can. J. Biochem. Cell Biol."},{"key":"10.1194\/jlr.M800042-JLR200_bib17","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1194\/jlr.M600198-JLR200","article-title":"Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1","volume":"47","author":"Rizki","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800042-JLR200_bib18","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s00335-006-0054-2","article-title":"Quantitative trait loci for individual adipose depot weights in C57BL\/6ByJ \u00d7 129P3\/J F2 mice","volume":"17","author":"Reed","year":"2006","journal-title":"Mamm. Genome."},{"key":"10.1194\/jlr.M800042-JLR200_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/bj20040134","article-title":"Intracerebroventricular leptin regulates hepatic cholesterol metabolism","volume":"379","author":"Vanpatten","year":"2004","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M800042-JLR200_bib20","doi-asserted-by":"crossref","first-page":"28662","DOI":"10.1074\/jbc.M403271200","article-title":"The peroxisome proliferator-activated receptor alpha (PPARalpha) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor-deficient mice: effects on plasma lipoproteins and the development of atherosclerotic lesions","volume":"279","author":"Fu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800042-JLR200_bib21","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1053\/j.gastro.2006.02.006","article-title":"Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis","volume":"130","author":"Doege","year":"2006","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M800042-JLR200_bib22","doi-asserted-by":"crossref","first-page":"8625","DOI":"10.1073\/pnas.95.15.8625","article-title":"A family of fatty acid transporters conserved from mycobacterium to man","volume":"95","author":"Hirsch","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M800042-JLR200_bib23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jhep.2003.12.011","article-title":"The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice","volume":"40","author":"Mensenkamp","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib24","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/S0022-2275(20)32437-8","article-title":"Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B","volume":"40","author":"Tietge","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800042-JLR200_bib25","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff","year":"2004","journal-title":"Biophotonics International."},{"key":"10.1194\/jlr.M800042-JLR200_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/hep.20999","article-title":"JNK1 but not JNK2 promotes the development of steatohepatitis in mice","volume":"43","author":"Schattenberg","year":"2006","journal-title":"Hepatology."},{"key":"10.1194\/jlr.M800042-JLR200_bib27","doi-asserted-by":"crossref","first-page":"9887","DOI":"10.1074\/jbc.M410310200","article-title":"Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling","volume":"280","author":"Schattenberg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800042-JLR200_bib28","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jhep.2004.08.010","article-title":"Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice","volume":"41","author":"Leclercq","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/labinvest.3700489","article-title":"Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone","volume":"87","author":"Leclercq","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1194\/jlr.M800042-JLR200_bib30","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1053\/j.gastro.2005.09.004","article-title":"NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis","volume":"129","author":"Dela Pena","year":"2005","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M800042-JLR200_bib31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.gastro.2006.10.014","article-title":"Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis","volume":"132","author":"Ota","year":"2007","journal-title":"Gastroenterology."},{"key":"10.1194\/jlr.M800042-JLR200_bib32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/ncpgasthep0186","article-title":"Mechanisms of disease. Adipocytokines and visceral adipose tissue\u2014emerging role in nonalcoholic fatty liver disease","volume":"2","author":"Schaffler","year":"2005","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib33","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1210\/en.2003-0285","article-title":"Minireview. Adiposity, inflammation, and atherogenesis","volume":"144","author":"Lyon","year":"2003","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M800042-JLR200_bib34","doi-asserted-by":"crossref","first-page":"37735","DOI":"10.1074\/jbc.R100035200","article-title":"Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism","volume":"276","author":"Lu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800042-JLR200_bib35","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1101\/gad.844900","article-title":"Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta","volume":"14","author":"Repa","year":"2000","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M800042-JLR200_bib36","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M800042-JLR200_bib37","doi-asserted-by":"crossref","first-page":"25164","DOI":"10.1074\/jbc.M402781200","article-title":"Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms","volume":"279","author":"Miyazaki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800042-JLR200_bib38","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2337\/db05-0742","article-title":"Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c","volume":"55","author":"Biddinger","year":"2006","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M800042-JLR200_bib39","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0022-2275(20)37412-5","article-title":"Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100","volume":"38","author":"Li","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800042-JLR200_bib40","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0168-8278(89)90148-7","article-title":"Mechanism of hepatic fatty acid uptake","volume":"9","author":"Stremmel","year":"1989","journal-title":"J. Hepatol."},{"key":"10.1194\/jlr.M800042-JLR200_bib41","doi-asserted-by":"crossref","first-page":"36300","DOI":"10.1074\/jbc.274.51.36300","article-title":"The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase","volume":"274","author":"Coe","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800042-JLR200_bib42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0005-2760(95)00003-U","article-title":"Evidence for a hepatocyte membrane fatty acid transport protein using rat liver mRNA expression in Xenopus laevis oocytes","volume":"1256","author":"Fitscher","year":"1995","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M800042-JLR200_bib43","first-page":"776","article-title":"[The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats.]","volume":"13","author":"Feng","year":"2005","journal-title":"Zhonghua Gan Zang Bing Za Zhi."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520425945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520425945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M800042-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T23:22:59Z","timestamp":1637450579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520425945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0022227520425945"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m800042-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}