{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:02:55Z","timestamp":1790974975380,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":4465,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1194\/jlr.m800061-jlr200","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T00:48:36Z","timestamp":1206406116000},"page":"1519-1528","source":"Crossref","is-referenced-by-count":78,"title":["Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis*"],"prefix":"10.1016","volume":"49","author":[{"given":"Peixiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"O'Loughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Brindley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Reue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M800061-JLR200_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/83685","article-title":"Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin","volume":"27","author":"P\u00e9terfy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.M800061-JLR200_bib2","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0022-2275(20)32011-3","article-title":"Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene","volume":"41","author":"K","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800061-JLR200_bib3","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1074\/jbc.M600425200","article-title":"The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme","volume":"281","author":"Han","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800061-JLR200_bib4","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1074\/jbc.M610745200","article-title":"Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns","volume":"282","author":"Donkor","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800061-JLR200_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmet.2004.12.002","article-title":"Lipin, a lipodystrophy and obesity gene","volume":"1","author":"Phan","year":"2005","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M800061-JLR200_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1210\/jc.2007-1535","article-title":"Adipose tissue lipin-1 expression is correlated with PPARalpha gene expression and insulin sensitivity in healthy young men","volume":"93","author":"Donkor","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.M800061-JLR200_bib7","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.metabol.2007.06.019","article-title":"Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus-associated lipodystrophy syndrome","volume":"56","author":"Miranda","year":"2007","journal-title":"Metabolism."},{"key":"10.1194\/jlr.M800061-JLR200_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/hmg\/ddi448","article-title":"Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism","volume":"15","author":"Suviolahti","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.M800061-JLR200_bib9","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.2337\/db05-1688","article-title":"Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation","volume":"55","author":"Yao-Borengasser","year":"2006","journal-title":"Diabetes."},{"key":"10.1194\/jlr.M800061-JLR200_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1194\/jlr.M600272-JLR200","article-title":"A role of lipin in human obesity and insulin resistance: relation to adiopcyte glucose transport and GLUT4 expression","volume":"48","author":"van Harmelen","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800061-JLR200_bib11","first-page":"21","article-title":"Phosphatidate phosphohydrolase activity in the liver","author":"Brindley","year":"1988","journal-title":"In Phosphatidate Phosphohydrolase: Its Role in Glycerolipid Synthesis. CRC Press, Inc., Boca Raton"},{"key":"10.1194\/jlr.M800061-JLR200_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/bj1800195","article-title":"The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol","volume":"180","author":"Brindley","year":"1979","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M800061-JLR200_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1042\/bj2250455","article-title":"Effects of cyclic AMP, glucocorticoids and insulin on the activities of phosphatidate phosphohydrolase, tyrosine aminotransferase and glycerol kinase in isolated rat hepatocytes in relation to the control of triacylglycerol synthesis and gluconeogenesis","volume":"225","author":"Pittner","year":"1985","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M800061-JLR200_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/bj2300525","article-title":"Interactions of insulin, glucagon and dexamethasone in controlling the activity of glycerol phosphate acyltransferase and the activity and subcellular distribution of phosphatidate phosphohydrolase in cultured rat hepatocytes","volume":"230","author":"Pittner","year":"1985","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M800061-JLR200_bib15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cmet.2007.03.010","article-title":"The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression","volume":"5","author":"Waki","year":"2007","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M800061-JLR200_bib16","doi-asserted-by":"crossref","first-page":"29558","DOI":"10.1074\/jbc.M403506200","article-title":"Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro","volume":"279","author":"Phan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800061-JLR200_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cmet.2006.07.001","article-title":"Transcriptional control of adipocyte formation","volume":"4","author":"Farmer","year":"2006","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M800061-JLR200_bib18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrm2066","article-title":"Adipocyte differentiation from the inside out","volume":"7","author":"Rosen","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1194\/jlr.M800061-JLR200_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M800061-JLR200_bib20","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1002\/j.1460-2075.1996.tb00918.x","article-title":"PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene","volume":"15","author":"Schoonjans","year":"1996","journal-title":"EMBO J."},{"key":"10.1194\/jlr.M800061-JLR200_bib21","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1101\/gad.8.10.1224","article-title":"mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer","volume":"8","author":"Tontonoz","year":"1994","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M800061-JLR200_bib22","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1074\/jbc.M503885200","article-title":"Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis","volume":"280","author":"P\u00e9terfy","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800061-JLR200_bib23","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1073\/pnas.022634399","article-title":"Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin","volume":"99","author":"Huffman","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M800061-JLR200_bib24","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1042\/bj2190911","article-title":"Oleic acid promotes the activation and translocation of phosphatidate phosphohydrolase from the cytosol to particulate fractions of isolated rat hepatocytes","volume":"219","author":"Cascales","year":"1988","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M800061-JLR200_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cmet.2006.08.005","article-title":"Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha\/PPARalpha regulatory pathway","volume":"4","author":"Finck","year":"2006","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.M800061-JLR200_bib26","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1073\/pnas.96.4.1279","article-title":"Role of calpain in adipocyte differentiation","volume":"96","author":"Patel","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M800061-JLR200_bib27","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1101\/gad.12.21.3343","article-title":"Structure and specificity of nuclear receptor-coactivator interactions","volume":"12","author":"Darimont","year":"1998","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M800061-JLR200_bib28","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1210\/me.2003-0384","article-title":"Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expression","volume":"18","author":"Herzog","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1194\/jlr.M800061-JLR200_bib29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1074\/jbc.M609537200","article-title":"Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1","volume":"282","author":"Harris","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800061-JLR200_bib30","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1038\/nprot.2006.480","article-title":"5\u2032 end cDNA amplificaiton using classic RACE","volume":"1","author":"Scotto-Lavino","year":"2006","journal-title":"Nat. Protocols."},{"key":"10.1194\/jlr.M800061-JLR200_bib31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1006\/geno.1999.6023","article-title":"Genetic, physical, and transcript map of the fld region on mouse chromosome 12","volume":"62","author":"Peterfy","year":"1999","journal-title":"Genomics."},{"key":"10.1194\/jlr.M800061-JLR200_bib32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/BF03347544","article-title":"Tissue-specific dysregulation of 11beta-hydroxysteroid dehydrogenase type 1 and pathogenesis of the metabolic syndrome","volume":"27","author":"Putignano","year":"2004","journal-title":"J. Endocrinol. Invest."},{"key":"10.1194\/jlr.M800061-JLR200_bib33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1098-3597(06)80039-6","article-title":"Adipose tissue dysfunction in obesity and lipodystrophy","volume":"8","author":"Garg","year":"2006","journal-title":"Clin. Cornerstone."},{"key":"10.1194\/jlr.M800061-JLR200_bib34","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/01.mco.0000232904.82038.db","article-title":"Metabolic consequences of lipodystrophy in mouse models","volume":"9","author":"Reue","year":"2006","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"10.1194\/jlr.M800061-JLR200_bib35","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1194\/jlr.M800013-JLR200","article-title":"Glucocorticoids and cAMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically","volume":"49","author":"Manmontri","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800061-JLR200_bib36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/dnares\/dsi003","article-title":"Genome-wide expression analysis reveals 100 adrenal gland-dependent circadian genes in the mouse liver","volume":"12","author":"Oishi","year":"2005","journal-title":"DNA Res."},{"key":"10.1194\/jlr.M800061-JLR200_bib37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1042\/bj1800441","article-title":"Control of hepatic triacylglycerol synthesis. Diurnal variations in hepatic phosphatidate phosphohydrolase activity and in the concentrations of circulating insulin and corticosterone in rats","volume":"180","author":"Knox","year":"1979","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.M800061-JLR200_bib38","first-page":"73","article-title":"Neuroendocrine regulation and obesity","volume":"16","author":"Brindley","year":"1992","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1194\/jlr.M800061-JLR200_bib39","first-page":"789","article-title":"Phosphatidate phosphohydrolases in liver, heart and adipose tissue of the JCR:LA corpulent rat and the lean genotypes: implications for glycerolipid synthesis and signal transduction","volume":"16","author":"Jamal","year":"1992","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1194\/jlr.M800061-JLR200_bib40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1101\/gad.1263305","article-title":"Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes","volume":"19","author":"Guan","year":"2005","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.M800061-JLR200_bib41","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1124\/mol.104.004895","article-title":"Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway","volume":"67","author":"Ialenti","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1194\/jlr.M800061-JLR200_bib42","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.2337\/db07-0480","article-title":"Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss","volume":"56","author":"Croce","year":"2007","journal-title":"Diabetes."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520347234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520347234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M800061-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T18:32:38Z","timestamp":1637433158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520347234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0022227520347234"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m800061-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}