{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:40:31Z","timestamp":1792712431726,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":4135,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1194\/jlr.m800460-jlr200","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T02:41:17Z","timestamp":1231814477000},"page":"787-797","source":"Crossref","is-referenced-by-count":86,"title":["A robust rabbit model of human atherosclerosis and atherothrombosis"],"prefix":"10.1016","volume":"50","author":[{"given":"Alkystis","family":"Phinikaridou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Hallock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M800460-JLR200_bib1","first-page":"I19","article-title":"Anatomic features in victims of sudden coronary death. Coronary artery pathology","volume":"85","author":"Davies","year":"1992","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib2","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199705013361802","article-title":"Coronary risk factors and plaque morphology in men with coronary disease who died suddenly","volume":"336","author":"Burke","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M800460-JLR200_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/(SICI)1096-9896(199701)181:1<93::AID-PATH696>3.0.CO;2-H","article-title":"Association of coronary plaque rupture and atherosclerotic inflammation","volume":"181","author":"Boyle","year":"1997","journal-title":"J. Pathol."},{"key":"10.1194\/jlr.M800460-JLR200_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","article-title":"Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology","volume":"89","author":"van der Wal","year":"1994","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib5","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1161\/CIRCULATIONAHA.105.578955","article-title":"Neovascularization in human atherosclerosis","volume":"113","author":"Moreno","year":"2006","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib6","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1161\/01.CIR.0000017265.52501.37","article-title":"Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability","volume":"105","author":"Moreno","year":"2002","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib7","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1056\/NEJMoa035655","article-title":"Intraplaque hemorrhage and progression of coronary atheroma","volume":"349","author":"Kolodgie","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M800460-JLR200_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9150(99)00371-8","article-title":"Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteases 1, 2 and 9 in the human coronary artery","volume":"150","author":"Pasterkamp","year":"2000","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M800460-JLR200_bib9","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.CIR.93.7.1354","article-title":"Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death","volume":"93","author":"Farb","year":"1996","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0021-9150(90)90178-L","article-title":"Animal models of atherosclerosis","volume":"85","author":"Armstrong","year":"1990","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M800460-JLR200_bib11","series-title":"Atherosclerosis: Experimental Methods and Protocols","author":"Drew","year":"2000"},{"key":"10.1194\/jlr.M800460-JLR200_bib12","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1161\/01.ATV.0000097783.01596.E2","article-title":"Atherosclerotic plaque rupture: local or systemic process?","volume":"23","author":"Lutgens","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M800460-JLR200_bib13","first-page":"1","article-title":"Ueber experimentelle cholesterinsteatose und ihre bedeutung f\u00fcr die entstehung einiger pathologischer prozesse","volume":"24","author":"Anitschkow","year":"1913","journal-title":"Centrbl. Allg. Pathol. Pathol. Anat."},{"key":"10.1194\/jlr.M800460-JLR200_bib14","first-page":"247","article-title":"Acceleration of intimal atherogenesis through prior medial injury","volume":"66","author":"Constantinides","year":"1958","journal-title":"AMA Arch. Pathol."},{"key":"10.1194\/jlr.M800460-JLR200_bib15","first-page":"80","article-title":"Production of advanced cholesterol atherosclerosis in the rabbit","volume":"70","author":"Constantinides","year":"1960","journal-title":"Arch. Pathol."},{"key":"10.1194\/jlr.M800460-JLR200_bib16","first-page":"197","article-title":"Rabbit arterial thrombosis production by systemic procedures","volume":"72","author":"Constantinides","year":"1961","journal-title":"Arch. Pathol."},{"key":"10.1194\/jlr.M800460-JLR200_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0021-9150(74)90061-6","article-title":"Regression of atherosclerosis in rabbits. I. Treatment with low-fat diet, hyperoxia and hypolipidemic agents","volume":"19","author":"Vesselinovitch","year":"1974","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M800460-JLR200_bib18","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/01.CIR.84.2.755","article-title":"Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery","volume":"84","author":"Weidinger","year":"1991","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib19","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.CIR.91.3.776","article-title":"Triggering of plaque disruption and arterial thrombosis in an atherosclerotic rabbit model","volume":"91","author":"Abela","year":"1995","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib20","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1161\/hq0901.094242","article-title":"In vivo magnetic resonance imaging of experimental thrombosis in a rabbit model","volume":"21","author":"Johnstone","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M800460-JLR200_bib21","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/01.CIR.0000134960.31304.87","article-title":"In vivo magnetic resonance imaging of coronary thrombosis using a fibrin-binding molecular magnetic resonance contrast agent","volume":"110","author":"Botnar","year":"2004","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib22","series-title":"Atherosclerosis III","first-page":"319","article-title":"Differences between Human and Animal Atherosclerosis","author":"Wissler","year":"1974"},{"key":"10.1194\/jlr.M800460-JLR200_bib23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1055\/s-0037-1616233","article-title":"Atherosclerosis and thrombosis: lessons from animal models","volume":"86","author":"Badimon","year":"2001","journal-title":"Thromb. Haemost."},{"key":"10.1194\/jlr.M800460-JLR200_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/01.RES.83.7.705","article-title":"Animal model that mimics atherosclerotic plaque rupture","volume":"83","author":"Rekhter","year":"1998","journal-title":"Circ. Res."},{"key":"10.1194\/jlr.M800460-JLR200_bib25","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/207730a0","article-title":"Actions of some coagulant snake venoms on blood platelets","volume":"207","author":"Davey","year":"1965","journal-title":"Nature."},{"key":"10.1194\/jlr.M800460-JLR200_bib26","first-page":"99","article-title":"Ultrastructural injury of arterial endothelium","volume":"88","author":"Constantinides","year":"1969","journal-title":"Arch. Pathol."},{"key":"10.1194\/jlr.M800460-JLR200_bib27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/00005344-198905000-00015","article-title":"Role of serotonin, histamine, and thromboxane A2 in platelet-induced contractions of coronary arteries and aortae from rabbits","volume":"13","author":"Awano","year":"1989","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1194\/jlr.M800460-JLR200_bib28","first-page":"I19","article-title":"Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults","volume":"9","author":"Stary","year":"1989","journal-title":"Arteriosclerosis."},{"key":"10.1194\/jlr.M800460-JLR200_bib29","series-title":"Handbook of Lipid Research: The Physical Chemistry of Lipids. From Alkanes to Phospholipids","author":"Small","year":"1986"},{"key":"10.1194\/jlr.M800460-JLR200_bib30","first-page":"702","article-title":"Identification and detection of in situ cellular and regional differences of lipid composition and class in lipid-rich tissue using hot stage polarizing light microscopy","volume":"51","author":"Waugh","year":"1984","journal-title":"Lab. Invest."},{"key":"10.1194\/jlr.M800460-JLR200_bib31","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.ATV.15.9.1512","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"15","author":"Stary","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M800460-JLR200_bib32","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"92","author":"Stary","year":"1995","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/hc0302.102610","article-title":"Morphological predictors of arterial remodeling in coronary atherosclerosis","volume":"105","author":"Burke","year":"2002","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib34","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0735-1097(95)80017-B","article-title":"Remodeling of de novo atherosclerotic lesions in femoral arteries: impact on mechanism of balloon angioplasty","volume":"26","author":"Pasterkamp","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.M800460-JLR200_bib35","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1161\/01.ATV.17.11.3057","article-title":"The impact of atherosclerotic arterial remodeling on percentage of luminal stenosis varies widely within the arterial system. A postmortem study","volume":"17","author":"Pasterkamp","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.M800460-JLR200_bib36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00019501-200411000-00009","article-title":"Novel insights into coronary lumen preservation during progression of coronary atherosclerosis in coronary atherosclerosis-prone rabbits","volume":"15","author":"Shiomi","year":"2004","journal-title":"Coron. Artery Dis."},{"key":"10.1194\/jlr.M800460-JLR200_bib37","series-title":"Experimental Atherosclerosis","author":"Constantinides","year":"1965"},{"key":"10.1194\/jlr.M800460-JLR200_bib38","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJM197608122950707","article-title":"The pathogenesis of atherosclerosis (first of two parts)","volume":"295","author":"Ross","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M800460-JLR200_bib39","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1056\/NEJM197608192950805","article-title":"The pathogenesis of atherosclerosis (second of two parts)","volume":"295","author":"Ross","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M800460-JLR200_bib40","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1172\/JCI117619","article-title":"Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques","volume":"94","author":"Galis","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M800460-JLR200_bib41","doi-asserted-by":"crossref","first-page":"C13","DOI":"10.1016\/j.jacc.2005.10.065","article-title":"Pathology of the vulnerable plaque","volume":"47","author":"Virmani","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.M800460-JLR200_bib42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11239-006-7861-x","article-title":"Arterial wall cholesterol content is a predictor of development and severity of arterial thrombosis","volume":"22","author":"Ma","year":"2006","journal-title":"J. Thromb. Thrombolysis."},{"key":"10.1194\/jlr.M800460-JLR200_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/sca.4950280101","article-title":"Cholesterol crystals rupture biological membranes and human plaques during acute cardiovascular events\u2013a novel insight into plaque rupture by scanning electron microscopy","volume":"28","author":"Abela","year":"2006","journal-title":"Scanning."},{"key":"10.1194\/jlr.M800460-JLR200_bib44","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0046-8177(95)90148-5","article-title":"Intimal neovascularization in human coronary atherosclerosis: Its origin and pathophysiological significance","volume":"26","author":"Kumamoto","year":"1995","journal-title":"Hum. Pathol."},{"key":"10.1194\/jlr.M800460-JLR200_bib45","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/01.CIR.0000143233.87854.23","article-title":"Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability","volume":"110","author":"Moreno","year":"2004","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib46","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1056\/NEJM198705283162204","article-title":"Compensatory enlargement of human atherosclerotic coronary arteries","volume":"316","author":"Glagov","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M800460-JLR200_bib47","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/hc0802.104327","article-title":"Relationship between coronary artery remodeling and plaque vulnerability","volume":"105","author":"Varnava","year":"2002","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/01.CIR.20.4.511","article-title":"Autopsy studies in atherosclerosis. I. Distribution and severity of atherosclerosis in patients dying without morphologic evidence of atherosclerotic catastrophe","volume":"20","author":"Roberts","year":"1959","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib49","first-page":"558","article-title":"Atherosclerosis of human aorta and its coronary and renal arteries. A consideration of some hemodynamic factors which may be related to the marked differences in atherosclerotic involvement of the coronary and renal arteries","volume":"72","author":"Glagov","year":"1961","journal-title":"Arch. Pathol."},{"key":"10.1194\/jlr.M800460-JLR200_bib50","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1115\/1.2891385","article-title":"Topographical mapping of sites of enhanced HRP permeability in the normal rabbit aorta","volume":"114","author":"Barakat","year":"1992","journal-title":"J. Biomech. Eng."},{"key":"10.1194\/jlr.M800460-JLR200_bib51","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0735-1097(97)00537-8","article-title":"Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys","volume":"31","author":"Williams","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.M800460-JLR200_bib52","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1161\/01.CIR.97.24.2433","article-title":"Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization","volume":"97","author":"Aikawa","year":"1998","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib53","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jacc.2003.08.048","article-title":"The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging","volume":"43","author":"Corti","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.M800460-JLR200_bib54","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/01.CIR.103.7.926","article-title":"Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization","volume":"103","author":"Crisby","year":"2001","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib55","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0140-6736(00)04053-8","article-title":"Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial","volume":"357","author":"Smilde","year":"2001","journal-title":"Lancet."},{"key":"10.1194\/jlr.M800460-JLR200_bib56","doi-asserted-by":"crossref","first-page":"554","DOI":"10.7326\/0003-4819-130-7-199904060-00003","article-title":"The effect of dietary {omega}-3 fatty acids on coronary atherosclerosis: a randomized, double-blind, placebo-controlled trial","volume":"130","author":"von Schacky","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"10.1194\/jlr.M800460-JLR200_bib57","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1161\/01.CIR.0000143627.55926.4C","article-title":"Angiotensin receptor blockade with candesartan attenuates atherosclerosis, plaque disruption, and macrophage accumulation within the plaque in a rabbit model","volume":"110","author":"Johnstone","year":"2004","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib58","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/01.CIR.103.7.934","article-title":"Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression","volume":"103","author":"Burke","year":"2001","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800460-JLR200_bib59","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1161\/CIRCULATIONAHA.108.764779","article-title":"Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration","volume":"118","author":"Qiao","year":"2008","journal-title":"Circulation."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520308312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520308312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M800460-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T15:24:15Z","timestamp":1637421855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520308312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022227520308312"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m800460-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}