{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:26:28Z","timestamp":1773739588438,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":4135,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1194\/jlr.m800553-jlr200","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T02:36:20Z","timestamp":1229999780000},"page":"938-944","source":"Crossref","is-referenced-by-count":30,"title":["The thyromimetic T-0681 protects from atherosclerosis"],"prefix":"10.1016","volume":"50","author":[{"given":"Ivan","family":"Tancevski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Wehinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egon","family":"Demetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Hoefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Eller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Stanzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Duwensee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Auer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Schgoer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Fievet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans","family":"Stellaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Rudling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Foeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef R.","family":"Patsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ritsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.M800553-JLR200_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/10507250252949405","article-title":"Thyroid disease and lipids","volume":"12","author":"Duntas","year":"2002","journal-title":"Thyroid."},{"key":"10.1194\/jlr.M800553-JLR200_bib2","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/endo-127-3-1144","article-title":"Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats","volume":"127","author":"Staels","year":"1990","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M800553-JLR200_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/bbrc.1998.9174","article-title":"Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene","volume":"249","author":"Bakker","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.M800553-JLR200_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0021-9150(86)90129-2","article-title":"Experimental hypothyroidism modulates the expression of the low density lipoprotein receptor by the liver","volume":"59","author":"Scarabottolo","year":"1986","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M800553-JLR200_bib5","first-page":"1209","article-title":"Thyroid replacement therapy and its influence on postheparin plasma lipases and apolipoprotein-B metabolism in hypothyroidism","volume":"76","author":"Packard","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.M800553-JLR200_bib6","doi-asserted-by":"crossref","first-page":"10297","DOI":"10.1073\/pnas.0504379102","article-title":"Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice","volume":"102","author":"Johansson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M800553-JLR200_bib7","first-page":"1137","article-title":"Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects","volume":"37","author":"Morkin","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1194\/jlr.M800553-JLR200_bib8","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1210\/me.2002-0009","article-title":"Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice","volume":"16","author":"Gullberg","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1194\/jlr.M800553-JLR200_bib9","doi-asserted-by":"crossref","first-page":"10067","DOI":"10.1073\/pnas.1633737100","article-title":"Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability","volume":"100","author":"Grover","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M800553-JLR200_bib10","doi-asserted-by":"crossref","first-page":"15490","DOI":"10.1073\/pnas.0702759104","article-title":"Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index","volume":"104","author":"Erion","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M800553-JLR200_bib11","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1073\/pnas.0705286104","article-title":"The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans","volume":"105","author":"Berkenstam","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M800553-JLR200_bib12","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00204-004-0561-4","article-title":"Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation","volume":"78","author":"Hayashi","year":"2004","journal-title":"Arch. Toxicol."},{"key":"10.1194\/jlr.M800553-JLR200_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1194\/jlr.M300353-JLR200","article-title":"Molecular characterization of rabbit scavenger receptor class B types I and II: portal to central vein gradient of expression in the liver","volume":"45","author":"Ritsch","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800553-JLR200_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00041433-200304000-00009","article-title":"Cholesteryl ester transfer protein: gathering momentum as a genetic marker and as drug target","volume":"14","author":"Ritsch","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1194\/jlr.M800553-JLR200_bib15","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00109-005-0695-8","article-title":"Increased plasma levels of LDL cholesterol in rabbits after adenoviral overexpression of human scavenger receptor class B type I","volume":"83","author":"Tancevski","year":"2005","journal-title":"J. Mol. Med."},{"key":"10.1194\/jlr.M800553-JLR200_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1172\/JCI0215748","article-title":"Increased ABCA1 activity protects against atherosclerosis","volume":"110","author":"Singaraja","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M800553-JLR200_bib17","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1172\/JCI116222","article-title":"Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities","volume":"91","author":"Miesenbock","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.M800553-JLR200_bib18","doi-asserted-by":"crossref","first-page":"29024","DOI":"10.1074\/jbc.M304855200","article-title":"Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia","volume":"278","author":"Jones","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800553-JLR200_bib19","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1096\/fj.05-5368com","article-title":"Aspirin regulates expression and function of scavenger receptor-BI in macrophages: studies in primary human macrophages and in mice","volume":"20","author":"Tancevski","year":"2006","journal-title":"FASEB J."},{"key":"10.1194\/jlr.M800553-JLR200_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cca.2007.11.025","article-title":"Effect of tumor necrosis factor alpha on cholesterol efflux in adipocytes","volume":"389","author":"Zhao","year":"2008","journal-title":"Clin. Chim. Acta."},{"key":"10.1194\/jlr.M800553-JLR200_bib21","series-title":"Bioinformatics Methods and Protocols: Methods in Molecular Biology","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","author":"Rozen","year":"2000"},{"key":"10.1194\/jlr.M800553-JLR200_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/cmt.4.3.219.227","article-title":"Influence of female and male sex steroids on body composition in the rabbit model","volume":"4","author":"Alexandersen","year":"2001","journal-title":"Climacteric."},{"key":"10.1194\/jlr.M800553-JLR200_bib23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1540-8175.2005.40096.x","article-title":"Effects of anesthesia on diastolic function in mice assessed by echocardiography","volume":"22","author":"Schaefer","year":"2005","journal-title":"Echocardiography."},{"key":"10.1194\/jlr.M800553-JLR200_bib24","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/S0022-2275(20)39713-3","article-title":"Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice","volume":"36","author":"Tangirala","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M800553-JLR200_bib25","doi-asserted-by":"crossref","first-page":"21001","DOI":"10.1074\/jbc.271.35.21001","volume":"271","author":"Wang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800553-JLR200_bib26","doi-asserted-by":"crossref","first-page":"16567","DOI":"10.1074\/jbc.M011302200","article-title":"Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I","volume":"276","author":"Han","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M800553-JLR200_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.atherosclerosis.2008.04.018","article-title":"Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-BI expression","volume":"202","author":"Niemeier","year":"2008","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.M800553-JLR200_bib28","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1210\/en.2007-1387","article-title":"Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5\u2032-triphosphate-binding cassette transporter 1 expression","volume":"149","author":"Tancevski","year":"2008","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.M800553-JLR200_bib29","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1161\/CIRCULATIONAHA.107.704254","article-title":"Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport","volume":"116","author":"Tanigawa","year":"2007","journal-title":"Circulation."},{"key":"10.1194\/jlr.M800553-JLR200_bib30","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJM193012252032601","article-title":"Blood cholesterol values in hyperthyroidism and hypothyroidism","volume":"203","author":"Mason","year":"1930","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.M800553-JLR200_bib31","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1001\/jama.1972.03200070084015","article-title":"The coronary drug project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. The coronary drug project research group","volume":"220","author":"The Coronary Drug Project Group","year":"1972","journal-title":"JAMA"},{"key":"10.1194\/jlr.M800553-JLR200_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/thy.2007.0248","article-title":"Metabolic effects of thyroid hormone derivatives","volume":"18","author":"Moreno","year":"2008","journal-title":"Thyroid."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520308464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520308464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M800553-JLR200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T15:24:41Z","timestamp":1637421881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520308464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022227520308464"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m800553-jlr200","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}