{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:35:34Z","timestamp":1771364134560,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":3324,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1194\/jlr.p013193","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T03:03:46Z","timestamp":1308884626000},"page":"1755-1759","source":"Crossref","is-referenced-by-count":24,"title":["Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease?"],"prefix":"10.1016","volume":"52","author":[{"given":"Pernette R.W.","family":"de Sauvage Nolting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Meeike","family":"Kusters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Hutten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.P.","family":"Kastelein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"for the ExPRESS study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.P013193_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2008.01.001","article-title":"Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin","volume":"198","author":"Schwertner","year":"2008","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.P013193_bib2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/01.ATV.16.2.250","article-title":"Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease","volume":"16","author":"Hopkins","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.P013193_bib3","first-page":"185","article-title":"Relationship between bilirubin, apolipoprotein B, and coronary artery disease","volume":"27","author":"Levinson","year":"1997","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1194\/jlr.P013193_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/clinchem\/40.1.18","article-title":"Association of low serum concentration of bilirubin with increased risk of coronary artery disease","volume":"40","author":"Schwertner","year":"1994","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.P013193_bib5","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/clinchem\/41.10.1504","article-title":"Serum bilirubin and risk of ischemic heart disease in middle-aged British men","volume":"41","author":"Breimer","year":"1995","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.P013193_bib6","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0002-9149(01)01494-1","article-title":"Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study","volume":"87","author":"Djousse","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.1194\/jlr.P013193_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.hjr.0000230097.81202.9f","article-title":"Bilirubin and coronary heart disease risk in the Prospective Epidemiological Study of Myocardial Infarction (PRIME)","volume":"14","author":"Troughton","year":"2007","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1194\/jlr.P013193_bib8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1023\/A:1013794407325","article-title":"Serum bilirubin and 10-year mortality risk in a Belgian population","volume":"12","author":"Temme","year":"2001","journal-title":"Cancer Causes Control."},{"key":"10.1194\/jlr.P013193_bib9","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.ATV.16.8.912","article-title":"Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees","volume":"16","author":"Hunt","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.P013193_bib10","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1177\/15353702-0322805-29","article-title":"Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies","volume":"228","author":"Novotny","year":"2003","journal-title":"Exp. Biol. Med. (Maywood)."},{"key":"10.1194\/jlr.P013193_bib11","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science."},{"key":"10.1194\/jlr.P013193_bib12","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.84.16.5918","article-title":"Antioxidant activity of albumin-bound bilirubin","volume":"84","author":"Stocker","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U SA."},{"key":"10.1194\/jlr.P013193_bib13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0024-3205(94)90140-6","article-title":"Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox","volume":"54","author":"Wu","year":"1994","journal-title":"Life Sci."},{"key":"10.1194\/jlr.P013193_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0304-4165(93)90013-X","article-title":"A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin","volume":"1158","author":"Nakagami","year":"1993","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.P013193_bib15","first-page":"1437","article-title":"[Higher prevalence of familial hypercholesterolemia than expected in adult patients of four family practices in Netherlands]","volume":"144","author":"Lansberg","year":"2000","journal-title":"Ned. Tijdschr. Geneeskd."},{"key":"10.1194\/jlr.P013193_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science."},{"key":"10.1194\/jlr.P013193_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9149(02)02449-9","article-title":"Two-year efficacy and safety of simvastatin 80 mg in familial hypercholesterolemia [the Examination of Probands and Relatives in Statin Studies with Familial Hypercholesterolemia (ExPRESS FH)]","volume":"90","author":"De Sauvage Nolting","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"10.1194\/jlr.P013193_bib18","series-title":"In Lipids and Vascular Disease.","first-page":"65","article-title":"Familial hypercholesterolaemia","author":"Defesche","year":"2000"},{"key":"10.1194\/jlr.P013193_bib19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.P013193_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/clinchem\/29.2.297","article-title":"A candidate reference method for determination of bilirubin in serum. Test for transferability","volume":"29","author":"Perry","year":"1983","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.P013193_bib21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1159\/000091966","article-title":"The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis","volume":"21","author":"Vitek","year":"2006","journal-title":"Cerebrovasc. Dis."},{"key":"10.1194\/jlr.P013193_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.atherosclerosis.2005.05.011","article-title":"Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women","volume":"184","author":"Erdogan","year":"2006","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.P013193_bib23","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0006-2952(95)02395-X","article-title":"Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins","volume":"51","author":"Wu","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1194\/jlr.P013193_bib24","doi-asserted-by":"crossref","first-page":"16712","DOI":"10.1016\/S0021-9258(19)89449-8","article-title":"Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation","volume":"269","author":"Neuzil","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P013193_bib25","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0006-291X(03)01504-3","article-title":"Heme oxygenase-1 induction may explain the antioxidant profile of aspirin","volume":"308","author":"Grosser","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.P013193_bib26","first-page":"243","article-title":"Effects of aspirin (acetylsalicylic acid) and Cataflam (potassium diclofenac) on some biochemical parameters in rats","volume":"27","author":"Ebong","year":"1998","journal-title":"Afr. J. Med. Med. Sci."},{"key":"10.1194\/jlr.P013193_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0021-9150(97)00232-3","article-title":"Association of smoking and low serum bilirubin antioxidant concentrations","volume":"136","author":"Schwertner","year":"1998","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.P013193_bib28","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1258\/acb.2009.008203","article-title":"Seasonal variation in liver function tests: a time-series analysis of outpatient data","volume":"46","author":"Miyake","year":"2009","journal-title":"Ann. Clin. Biochem."},{"key":"10.1194\/jlr.P013193_bib29","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2004.10.123","article-title":"Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1","volume":"325","author":"Grosser","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.P013193_bib30","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.freeradbiomed.2004.09.009","article-title":"The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells","volume":"37","author":"Grosser","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1194\/jlr.P013193_bib31","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.bbrc.2006.03.036","article-title":"Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo","volume":"343","author":"Hsu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.P013193_bib32","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1161\/01.CIR.0000140694.67251.9C","article-title":"Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection","volume":"110","author":"Lee","year":"2004","journal-title":"Circulation."},{"key":"10.1194\/jlr.P013193_bib33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0021-9150(00)00420-2","article-title":"Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study","volume":"154","author":"Hunt","year":"2001","journal-title":"Atherosclerosis."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520408673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520408673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.P013193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T21:58:49Z","timestamp":1637445529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520408673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0022227520408673"],"URL":"https:\/\/doi.org\/10.1194\/jlr.p013193","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}