{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:37:17Z","timestamp":1790617037449,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":1008,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-13-BSV1-0020-01"],"award-info":[{"award-number":["ANR-13-BSV1-0020-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Association Fran\u00e7aise contre les Myopathies","doi-asserted-by":"publisher","award":["13988"],"award-info":[{"award-number":["13988"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Association Fran\u00e7aise contre les Myopathies","doi-asserted-by":"publisher","award":["15947"],"award-info":[{"award-number":["15947"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Fondation Bettencourt","doi-asserted-by":"publisher","award":["2012"],"award-info":[{"award-number":["2012"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Fondation de l\u2019Avenir","doi-asserted-by":"publisher","award":["09071"],"award-info":[{"award-number":["09071"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Fondation Lejeune","doi-asserted-by":"publisher","award":["2014"],"award-info":[{"award-number":["2014"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Fondation Maladies Rares, Patient associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000147","name":"Canadian Breast Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1194\/jlr.p075440","type":"journal-article","created":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T01:05:15Z","timestamp":1507338315000},"page":"2348-2364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations"],"prefix":"10.1016","volume":"58","author":[{"given":"Michele","family":"Pelosi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Testet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soazig","family":"Le Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Dugail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Mabilleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamina","family":"Hamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Madrange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Odent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd P.W.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Alf\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Brindley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"de Lonlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.P075440_bib1","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1016\/S0021-9258(18)83141-6","article-title":"The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities","volume":"264","author":"Langner","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/9780470985571.ch6","article-title":"The role of lipin 1 in adipogenesis and lipid metabolism","volume":"286","author":"Reue","year":"2007","journal-title":"Novartis Found. Symp."},{"key":"10.1194\/jlr.P075440_bib3","doi-asserted-by":"crossref","first-page":"29558","DOI":"10.1074\/jbc.M403506200","article-title":"Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro","volume":"279","author":"Phan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1358\/dnp.2005.18.1.877165","article-title":"Biphasic expression of lipin suggests dual roles in adipocyte development","volume":"18","author":"Phan","year":"2005","journal-title":"Drug News Perspect."},{"key":"10.1194\/jlr.P075440_bib5","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1073\/pnas.1213493110","article-title":"Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation","volume":"110","author":"Mitra","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.P075440_bib6","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1074\/jbc.M503885200","article-title":"Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis","volume":"280","author":"P\u00e9eterfy","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/83685","article-title":"Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin","volume":"27","author":"P\u00e9terfy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.P075440_bib8","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1074\/jbc.M600425200","article-title":"The Saccharomyces cerevisiae lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme","volume":"281","author":"Han","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib9","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1074\/jbc.M610745200","article-title":"Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns","volume":"282","author":"Donkor","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib10","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bbalip.2012.08.006","article-title":"Phosphatidate phosphatase, a key regulator of lipid homeostasis","volume":"1831","author":"Pascual","year":"2013","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.P075440_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1677\/JOE-09-0359","article-title":"PPAR control: it's SIRTainly as easy as PGC","volume":"204","author":"Sugden","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1194\/jlr.P075440_bib12","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2011.06.034","article-title":"mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway","volume":"146","author":"Peterson","year":"2011","journal-title":"Cell."},{"key":"10.1194\/jlr.P075440_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cmet.2006.08.005","article-title":"Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha\/PPARalpha regulatory pathway","volume":"4","author":"Finck","year":"2006","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.P075440_bib14","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1128\/MCB.00512-12","article-title":"Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue","volume":"32","author":"Nadra","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.P075440_bib15","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1128\/MCB.01671-09","article-title":"Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors","volume":"30","author":"Kim","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.P075440_bib16","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/S0022-2275(20)32476-7","article-title":"The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins","volume":"39","author":"Rehnmark","year":"1998","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.P075440_bib17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.febslet.2007.11.014","article-title":"The lipin protein family: dual roles in lipid biosynthesis and gene expression","volume":"582","author":"Reue","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1194\/jlr.P075440_bib18","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.P075440_bib19","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.4049\/jimmunol.1400238","article-title":"Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages","volume":"193","author":"Meana","year":"2014","journal-title":"J. Immunol."},{"key":"10.1194\/jlr.P075440_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"Agarwal","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.P075440_bib21","doi-asserted-by":"crossref","first-page":"E1195","DOI":"10.1152\/ajpendo.90958.2008","article-title":"Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis","volume":"296","author":"Takeuchi","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1194\/jlr.P075440_bib22","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1101\/gad.1638008","article-title":"Phosphatidic acid mediates demyelination in Lpin1 mutant mice","volume":"22","author":"Nadra","year":"2008","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.P075440_bib23","doi-asserted-by":"crossref","first-page":"26781","DOI":"10.1074\/jbc.M110.197947","article-title":"A hypomorphic mutation in lpin1 induces progressively improving neuropathy and lipodystrophy in the rat","volume":"286","author":"Mul","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1194\/jlr.M019430","article-title":"Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice","volume":"53","author":"Kok","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.P075440_bib25","doi-asserted-by":"crossref","first-page":"34502","DOI":"10.1074\/jbc.M113.488445","article-title":"Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3\u2013L1 cells","volume":"288","author":"Sembongi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ajhg.2008.09.002","article-title":"Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood","volume":"83","author":"Zeharia","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1194\/jlr.P075440_bib27","doi-asserted-by":"crossref","first-page":"E1564","DOI":"10.1002\/humu.21282","article-title":"LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood","volume":"31","author":"Michot","year":"2010","journal-title":"Hum. Mutat."},{"key":"10.1194\/jlr.P075440_bib28","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.bbadis.2013.07.021","article-title":"Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts","volume":"1832","author":"Michot","year":"2013","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.P075440_bib29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cmet.2014.05.003","article-title":"Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle","volume":"20","author":"Zhang","year":"2014","journal-title":"Cell Metab."},{"key":"10.1194\/jlr.P075440_bib30","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00125-016-4018-0","article-title":"Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes","volume":"59","author":"Temprano","year":"2016","journal-title":"Diabetologia."},{"key":"10.1194\/jlr.P075440_bib31","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s10545-012-9461-6","article-title":"Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia","volume":"35","author":"Michot","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1194\/jlr.P075440_bib32","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2337\/db10-0856","article-title":"Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity","volume":"60","author":"Briand","year":"2011","journal-title":"Diabetes."},{"key":"10.1194\/jlr.P075440_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12859-015-0689-7","article-title":"Finite mixture clustering of human tissues with different levels of IGF-1 splice variants mRNA transcripts","volume":"16","author":"Pelosi","year":"2015","journal-title":"BMC Bioinformatics."},{"key":"10.1194\/jlr.P075440_bib34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0005-2760(65)90121-9","article-title":"Preparation and analysis of lipid extracts from milk and other tissues","volume":"98","author":"Galanos","year":"1965","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.P075440_bib35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0006-8993(86)80233-5","article-title":"A quantitative developmental study of neutral lipids during myelinogenesis in the peripheral nervous system of normal and trembler mice","volume":"390","author":"Juguelin","year":"1986","journal-title":"Brain Res."},{"key":"10.1194\/jlr.P075440_bib36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0021-9673(00)95654-1","article-title":"Thin-layer chromatography of phospholipids","volume":"166","author":"Vitiello","year":"1978","journal-title":"J. Chromatogr."},{"key":"10.1194\/jlr.P075440_bib37","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1080\/10826070802188940","article-title":"Separation of phospholipids by HPTLC \u2013 an investigation of important parameters","volume":"31","author":"Handloser","year":"2008","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1194\/jlr.P075440_bib38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/BJ20041491","article-title":"Ypr140wp, \u2018the yeast tafazzin\u2019, displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis","volume":"387","author":"Testet","year":"2005","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.P075440_bib39","doi-asserted-by":"crossref","first-page":"e1004711","DOI":"10.1371\/journal.pgen.1004711","article-title":"A thermolabile aldolase A mutant causes fever-induced recurrent rhabdomyolysis without hemolytic anemia","volume":"10","author":"Mamoune","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1194\/jlr.P075440_bib40","doi-asserted-by":"crossref","first-page":"206026","DOI":"10.1155\/2014\/206026","article-title":"IL-6 impairs myogenic differentiation by downmodulation of p90RSK\/eEF2 and mTOR\/p70S6K axes, without affecting AKT activity","volume":"2014","author":"Pelosi","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1194\/jlr.P075440_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0560.1986.tb00455.x","article-title":"Eosinophilic panniculitis: a clinicopathologic study","volume":"13","author":"Winkelmann","year":"1986","journal-title":"J. Cutan. Pathol."},{"key":"10.1194\/jlr.P075440_bib42","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1016\/S0021-9258(18)99168-4","article-title":"Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets","volume":"266","author":"Greenberg","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib43","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)80542-5","article-title":"A perfect message: RNA surveillance and nonsense-mediated decay","volume":"96","author":"Hentze","year":"1999","journal-title":"Cell."},{"key":"10.1194\/jlr.P075440_bib44","doi-asserted-by":"crossref","first-page":"E2486","DOI":"10.1073\/pnas.1205221109","article-title":"Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum","volume":"109","author":"Dwyer","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.P075440_bib45","doi-asserted-by":"crossref","first-page":"R130","DOI":"10.1186\/gb-2009-10-11-r130","article-title":"BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources","volume":"10","author":"Wu","year":"2009","journal-title":"Genome Biol."},{"key":"10.1194\/jlr.P075440_bib46","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1194\/jlr.D900014-JLR200","article-title":"Enzymatic measurement of phosphatidic acid in cultured cells","volume":"50","author":"Morita","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.P075440_bib47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.P075440_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI1411","article-title":"Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1\/SREBP1","volume":"101","author":"Kim","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.P075440_bib49","doi-asserted-by":"crossref","first-page":"32793","DOI":"10.1074\/jbc.M110.145995","article-title":"Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway","volume":"285","author":"Summermatter","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib50","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.2337\/diabetes.51.12.3586","article-title":"PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy","volume":"51","author":"Hegele","year":"2002","journal-title":"Diabetes."},{"key":"10.1194\/jlr.P075440_bib51","first-page":"408","article-title":"A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy","volume":"87","author":"Agarwal","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.P075440_bib52","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0022-2275(20)32011-3","article-title":"Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene","volume":"41","author":"Reue","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.P075440_bib53","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.73.12.4516","article-title":"Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine","volume":"73","author":"Russell","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.P075440_bib54","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.4049\/jimmunol.179.3.1595","article-title":"Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells","volume":"179","author":"Haniffa","year":"2007","journal-title":"J. Immunol."},{"key":"10.1194\/jlr.P075440_bib55","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3727\/000000005783992043","article-title":"Distinct gene expression profile of human mesenchymal stem cells in comparison to skin fibroblasts employing cDNA microarray analysis of 9600 genes","volume":"12","author":"Brendel","year":"2005","journal-title":"Gene Expr."},{"key":"10.1194\/jlr.P075440_bib56","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/scd.2010.0040","article-title":"Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging","volume":"20","author":"Halfon","year":"2011","journal-title":"Stem Cells Dev."},{"key":"10.1194\/jlr.P075440_bib57","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10875-010-9415-4","article-title":"Human fibroblasts share immunosuppressive properties with bone marrow mesenchymal stem cells","volume":"30","author":"Cappellesso-Fleury","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"10.1194\/jlr.P075440_bib58","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1101\/gad.10.9.1096","article-title":"ADD1\/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism","volume":"10","author":"Kim","year":"1996","journal-title":"Genes Dev."},{"key":"10.1194\/jlr.P075440_bib59","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1210\/jc.2003-030855","article-title":"Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy","volume":"88","author":"Agarwal","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.P075440_bib60","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.2337\/db05-1688","article-title":"Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation","volume":"55","author":"Yao-Borengasser","year":"2006","journal-title":"Diabetes."},{"key":"10.1194\/jlr.P075440_bib61","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magr\u00e9","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.P075440_bib62","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molmet.2012.11.002","article-title":"The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1","volume":"2","author":"Sim","year":"2012","journal-title":"Mol. Metab."},{"key":"10.1194\/jlr.P075440_bib63","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1210\/jc.2007-1535","article-title":"Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men","volume":"93","author":"Donkor","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.P075440_bib64","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.yjmcc.2011.04.009","article-title":"Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor gamma coactivator 1alpha\/estrogen related receptor axis","volume":"51","author":"Mitra","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1194\/jlr.P075440_bib65","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1128\/MCB.01335-10","article-title":"Lipin is a central regulator of adipose tissue development and function in Drosophila melanogaster","volume":"31","author":"Ugrankar","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.P075440_bib66","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1074\/jbc.M111.296681","article-title":"Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor gamma (PPARgamma) gene expression during adipogenesis","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.P075440_bib67","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jpeds.2012.02.033","article-title":"Fatal rhabdomyolysis in 2 children with LPIN1 mutations","volume":"160","author":"Bergounioux","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1194\/jlr.P075440_bib68","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.gene.2005.02.019","article-title":"Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia","volume":"352","author":"Zhou","year":"2005","journal-title":"Gene."},{"key":"10.1194\/jlr.P075440_bib69","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1021\/cr200433m","article-title":"Unlike two peas in a pod: lipid phosphate phosphatases and phosphatidate phosphatases","volume":"112","author":"Kok","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1194\/jlr.P075440_bib70","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1152\/ajpendo.90949.2008","article-title":"Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism","volume":"297","author":"Shi","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520335604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520335604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.P075440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T17:33:48Z","timestamp":1637429628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520335604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0022227520335604"],"URL":"https:\/\/doi.org\/10.1194\/jlr.p075440","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.P075440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}