{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:14:57Z","timestamp":1780499697324,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL35464"],"award-info":[{"award-number":["R01 HL35464"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA167552"],"award-info":[{"award-number":["UM1 CA167552"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1194\/jlr.p093823","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:19:27Z","timestamp":1559175567000},"page":"1457-1464","update-policy":"https:\/\/doi.org\/10.1194\/jlr.f110.005975","source":"Crossref","is-referenced-by-count":30,"title":["Cholesterol efflux capacity, HDL cholesterol, and risk of coronary heart disease: a nested case-control study in men"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-2227","authenticated-orcid":false,"given":"Leah E.","family":"Cahill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric B.","family":"Rimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majken K.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.P093823_bib1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pcad.2015.05.004","article-title":"High-density lipoprotein function measurement in human studies: focus on cholesterol efflux capacity","volume":"58","author":"Rohatgi","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1194\/jlr.P093823_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11892-015-0661-y","article-title":"New and emerging biomarkers in cardiovascular disease","volume":"15","author":"Cahill","year":"2015","journal-title":"Curr. Diab. Rep."},{"issue":"Suppl","key":"10.1194\/jlr.P093823_bib3","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1194\/jlr.R800088-JLR200","article-title":"The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis","volume":"50","author":"Rader","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.P093823_bib4","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1161\/ATVBAHA.112.300133","article-title":"High-density lipoprotein function, dysfunction, and reverse cholesterol transport","volume":"32","author":"Fisher","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.P093823_bib5","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1161\/CIRCULATIONAHA.111.066589","article-title":"Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport","volume":"125","author":"Rosenson","year":"2012","journal-title":"Circulation."},{"key":"10.1194\/jlr.P093823_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1194\/jlr.R039297","article-title":"Cardioprotective functions of HDLs","volume":"55","author":"Rye","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.P093823_bib7","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/jama.2009.1619","article-title":"Major lipids, apolipoproteins, and risk of vascular disease","volume":"302","author":"Emerging Risk Factors Collaborators","year":"2009","journal-title":"JAMA."},{"key":"10.1194\/jlr.P093823_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa1300955","article-title":"Effects of extended-release niacin with laropiprant in high-risk patients","volume":"371","author":"HPS2-THRIVE Collaborative Group","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib9","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMoa1107579","article-title":"Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy","volume":"365","author":"AIM HIGH Investigators","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib10","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1056\/NEJMoa1706444","article-title":"Effects of anacetrapib in patients with atherosclerotic vascular disease","volume":"377","author":"HPS3\/TIMI55\u2013REVEAL Collaborative Group","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib11","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1056\/NEJMoa1609581","article-title":"Evacetrapib and cardiovascular outcomes in high-risk vascular disease","volume":"376","author":"Lincoff","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib12","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(12)60312-2","article-title":"Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study","volume":"380","author":"Voight","year":"2012","journal-title":"Lancet."},{"key":"10.1194\/jlr.P093823_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1001689","article-title":"Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis","volume":"364","author":"Khera","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S2213-8587(15)00126-6","article-title":"Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study","volume":"3","author":"Saleheen","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1194\/jlr.P093823_bib15","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMoa1409065","article-title":"HDL cholesterol efflux capacity and incident cardiovascular events","volume":"371","author":"Rohatgi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib16","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/ATVBAHA.113.301373","article-title":"Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks","volume":"33","author":"Li","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.P093823_bib17","first-page":"1473","article-title":"Cholesterol efflux capacity and atherosclerosis","volume":"364","author":"de Vries","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib18","doi-asserted-by":"crossref","first-page":"e0157507","DOI":"10.1371\/journal.pone.0157507","article-title":"Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients","volume":"11","author":"Poto\u010dnjak","year":"2016","journal-title":"PLoS One."},{"key":"10.1194\/jlr.P093823_bib19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1681\/ASN.2016030262","article-title":"HDL cholesterol efflux does not predict cardiovascular risk in hemodialysis patients","volume":"28","author":"Kopecky","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1194\/jlr.P093823_bib20","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.healun.2016.06.022","article-title":"Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients","volume":"35","author":"Javaheri","year":"2016","journal-title":"J. Heart Lung Transplant."},{"key":"10.1194\/jlr.P093823_bib21","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/oxfordjournals.aje.a116211","article-title":"Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals","volume":"135","author":"Rimm","year":"1992","journal-title":"Am. J. Epidemiol."},{"key":"10.1194\/jlr.P093823_bib22","article-title":"Cardiovascular Survey Methods.","volume":"58","author":"Rose","year":"1982","journal-title":"WHO Monograph"},{"key":"10.1194\/jlr.P093823_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0140-6736(91)90542-W","article-title":"Prospective study of alcohol consumption and risk of coronary disease in men","volume":"338","author":"Rimm","year":"1991","journal-title":"Lancet."},{"key":"10.1194\/jlr.P093823_bib24","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/jnci\/90.17.1292","article-title":"Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women","volume":"90","author":"Hankinson","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1194\/jlr.P093823_bib25","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/clinchem\/48.10.1781","article-title":"Stability of novel plasma markers associated with cardiovascular disease: processing within 36 hours of specimen collection","volume":"48","author":"Pai","year":"2002","journal-title":"Clin. Chem."},{"key":"10.1194\/jlr.P093823_bib26","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/aje\/152.12.1171","article-title":"Leisure-time physical activity, television watching, and plasma biomarkers of obesity and cardiovascular disease risk","volume":"152","author":"Fung","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1194\/jlr.P093823_bib27","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1007\/s00125-004-1526-0","article-title":"Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men","volume":"47","author":"Shai","year":"2004","journal-title":"Diabetologia."},{"key":"10.1194\/jlr.P093823_bib28","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/aje\/kwm348","article-title":"Determination of blood pressure percentiles in normal-weight children: some methodological issues","volume":"167","author":"Rosner","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"10.1194\/jlr.P093823_bib29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s10549-012-2303-2","article-title":"Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, growth hormone, and mammographic density in the Nurses' Health Studies","volume":"136","author":"Rice","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1194\/jlr.P093823_bib30","first-page":"1870","article-title":"HDL cholesterol efflux capacity and cardiovascular events","volume":"372","author":"Ritsch","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.P093823_bib31","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.amjcard.2015.01.015","article-title":"Relation of black race between high density lipoprotein cholesterol content, high density lipoprotein particles and coronary events (from the Dallas Heart Study)","volume":"115","author":"Chandra","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"10.1194\/jlr.P093823_bib32","doi-asserted-by":"crossref","first-page":"27367","DOI":"10.1038\/srep27367","article-title":"Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study","volume":"6","author":"Annema","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1194\/jlr.P093823_bib33","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/CIRCULATIONAHA.116.025678","article-title":"Cholesterol efflux capacity, HDL particle number, and incident cardiovascular events: an analysis from the JUPITER trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)","volume":"135","author":"Khera","year":"2017","journal-title":"Circulation."},{"key":"10.1194\/jlr.P093823_bib34","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1161\/ATVBAHA.117.309201","article-title":"Large-scale analysis of determinants, stability, and heritability of high-density lipoprotein cholesterol efflux capacity","volume":"37","author":"Koekemoer","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.P093823_bib35","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1001\/jama.1986.03380200073024","article-title":"Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study","volume":"256","author":"Castelli","year":"1986","journal-title":"JAMA."},{"key":"10.1194\/jlr.P093823_bib36","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(08)61076-4","article-title":"Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study","volume":"372","author":"McQueen","year":"2008","journal-title":"Lancet."},{"key":"10.1194\/jlr.P093823_bib37","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrendo.2014.155","article-title":"Novel metabolic biomarkers of cardiovascular disease","volume":"10","author":"Jensen","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1194\/jlr.P093823_bib38","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/MOL.0000000000000317","article-title":"Modulating cholesterol efflux capacity to improve cardiovascular disease","volume":"27","author":"Brownell","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1194\/jlr.P093823_bib39","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0140-6736(14)61217-4","article-title":"HDL and cardiovascular disease","volume":"384","author":"Rader","year":"2014","journal-title":"Lancet."},{"key":"10.1194\/jlr.P093823_bib40","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/ATVBAHA.117.307025","article-title":"From high-density lipoprotein cholesterol to measurements of function: prospects for the development of tests for high-density lipoprotein functionality in cardiovascular disease","volume":"38","author":"Sacks","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.P093823_bib41","doi-asserted-by":"crossref","first-page":"98045","DOI":"10.1172\/jci.insight.98045","article-title":"Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk","volume":"3","author":"Morton","year":"2018","journal-title":"JCI Insight."},{"key":"10.1194\/jlr.P093823_bib42","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/CIRCULATIONAHA.117.031276","article-title":"High-density lipoprotein subspecies defined by presence of apolipoprotein C-III and incident coronary heart disease in four cohorts","volume":"137","author":"Jensen","year":"2018","journal-title":"Circulation."},{"key":"10.1194\/jlr.P093823_bib43","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1161\/ATVBAHA.118.311607","article-title":"Distinct proteomic signatures in 16 HDL (high-density lipoprotein) subspecies","volume":"38","author":"Furtado","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520322409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520322409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.P093823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T16:29:14Z","timestamp":1637425754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520322409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0022227520322409"],"URL":"https:\/\/doi.org\/10.1194\/jlr.p093823","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}