{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:21:01Z","timestamp":1792696861798,"version":"4.5.0"},"reference-count":145,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":1604,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002879","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["126076"],"award-info":[{"award-number":["126076"]}],"id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-13-0003091"],"award-info":[{"award-number":["G-13-0003091"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002790","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\/05006-2015"],"award-info":[{"award-number":["RGPIN\/05006-2015"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1194\/jlr.r060582","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T14:07:00Z","timestamp":1449670020000},"page":"745-757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":282,"title":["Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease?"],"prefix":"10.1016","volume":"57","author":[{"given":"Michael B.","family":"Boffa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlys L.","family":"Koschinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.R060582_bib1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1399-0004.1974.tb00657.x","article-title":"Lp(a) lipoprotein and pre-beta1-lipoprotein in patients with coronary heart disease","volume":"6","author":"Berg","year":"1974","journal-title":"Clin. Genet."},{"key":"10.1194\/jlr.R060582_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1399-0004.1975.tb00338.x","article-title":"Lp(a) lipoprotein\/pre-beta1-lipoprotein in Swedish middle-aged males and in patients with coronary heart disease","volume":"7","author":"Dahl\u00e9n","year":"1975","journal-title":"Clin. Genet."},{"key":"10.1194\/jlr.R060582_bib3","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1073\/pnas.84.10.3224","article-title":"Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen","volume":"84","author":"Eaton","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.R060582_bib4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/330132a0","article-title":"cDNA sequence of human apolipoprotein(a) is homologous to plasminogen","volume":"330","author":"McLean","year":"1987","journal-title":"Nature."},{"key":"10.1194\/jlr.R060582_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/339301a0","article-title":"A potential basis for the thrombotic risks associated with lipoprotein(a)","volume":"339","author":"Miles","year":"1989","journal-title":"Nature."},{"key":"10.1194\/jlr.R060582_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/339303a0","article-title":"Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis","volume":"339","author":"Hajjar","year":"1989","journal-title":"Nature."},{"key":"10.1194\/jlr.R060582_bib7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0014-5793(87)81501-6","article-title":"Molecular cloning and characterization of a full-length cDNA clone for human plasminogen","volume":"213","author":"Forsgren","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1194\/jlr.R060582_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0014-5793(84)80473-1","article-title":"Kringles: modules specialized for protein binding. Homology of the gelatin-binding region of fibronectin with the kringle structures of proteases","volume":"171","author":"Patthy","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1194\/jlr.R060582_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1055\/s-0038-1646368","article-title":"The structures of domains of blood proteins","volume":"66","author":"Tulinsky","year":"1991","journal-title":"Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(85)80046-5","article-title":"Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules","volume":"41","author":"Patthy","year":"1985","journal-title":"Cell."},{"key":"10.1194\/jlr.R060582_bib11","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1021\/bi00127a011","article-title":"Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis","volume":"31","author":"Ichinose","year":"1992","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/hmg\/2.4.361","article-title":"The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms","volume":"2","author":"van der Hoek","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.R060582_bib13","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/hmg\/2.7.933","article-title":"Molecular definition of the extreme size polymorphism in apolipoprotein(a)","volume":"2","author":"Lackner","year":"1993","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.R060582_bib14","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/S0022-2275(20)37461-7","article-title":"Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans","volume":"37","author":"Marcovina","year":"1996","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib15","doi-asserted-by":"crossref","first-page":"10936","DOI":"10.1021\/bi00092a002","article-title":"Amino acids of the recombinant kringle 1 domain of human plasminogen that stabilize its interaction with omega-amino acids","volume":"32","author":"Hoover","year":"1993","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib16","doi-asserted-by":"crossref","first-page":"32405","DOI":"10.1016\/S0021-9258(18)31649-1","article-title":"Amino acid residues of the kringle-4 and kringle-5 domains of human plasminogen that stabilize their interactions with omega-amino acid ligands","volume":"269","author":"McCance","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib17","first-page":"46","article-title":"The kringle domains of human plasminogen","volume":"212","author":"Castellino","year":"1997","journal-title":"Ciba Found. Symp."},{"key":"10.1194\/jlr.R060582_bib18","doi-asserted-by":"crossref","first-page":"13690","DOI":"10.1016\/S0021-9258(18)89800-3","article-title":"The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain","volume":"259","author":"V\u00e1li","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib19","doi-asserted-by":"crossref","first-page":"10589","DOI":"10.1021\/bi00107a030","article-title":"The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4","volume":"30","author":"Wu","year":"1991","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib20","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1021\/bi00244a035","article-title":"Characterization of the binding of plasminogen to fibrin surfaces: the role of carboxy-terminal lysines","volume":"30","author":"Fleury","year":"1991","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib21","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1016\/S0021-9258(17)30384-8","article-title":"The effect of alpha-,omega-amino acids on human plasminogen structure and activation","volume":"253","author":"Violand","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bj3330099","article-title":"Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide","volume":"333","author":"Cockell","year":"1998","journal-title":"Biochem. J."},{"key":"10.1194\/jlr.R060582_bib23","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/01.ATV.13.5.758","article-title":"Comparison of ligand-binding sites of modeled apo[a] kringle-like sequences in human lipoprotein","volume":"13","author":"Guevara","year":"1993","journal-title":"Arterioscler. Thromb."},{"key":"10.1194\/jlr.R060582_bib24","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1110\/ps.01701","article-title":"High-resolution crystal structure of apolipoprotein(a) kringle IV type 7: insights into ligand binding","volume":"10","author":"Ye","year":"2001","journal-title":"Protein Sci."},{"key":"10.1194\/jlr.R060582_bib25","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1021\/bi010964i","article-title":"Comparative analyses of the lysine binding site properties of apolipoprotein(a) kringle IV types 7 and 10","volume":"41","author":"Rahman","year":"2002","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib26","doi-asserted-by":"crossref","first-page":"11591","DOI":"10.1021\/bi971316v","article-title":"Ligand preferences of kringle 2 and homologous domains of human plasminogen: canvassing weak, intermediate, and high-affinity binding sites by 1H-NMR","volume":"36","author":"Marti","year":"1997","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib27","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1074\/jbc.270.11.6227","article-title":"Identification of two functionally distinct lysine-binding sites in kringle 37 and in kringles 32-36 of human apolipoprotein(a)","volume":"270","author":"Ernst","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib28","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1161\/01.ATV.16.12.1559","article-title":"Lipoprotein(a) assembly. Quantitative assessment of the role of apo(a) kringle IV types 2-10 in particle formation","volume":"16","author":"Gabel","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib29","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1074\/jbc.M309414200","article-title":"Quantitative evaluation of the contribution of weak lysine-binding sites present within apolipoprotein(a) kringle IV types 6\u20138 to lipoprotein(a) assembly","volume":"279","author":"Becker","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib30","doi-asserted-by":"crossref","first-page":"15777","DOI":"10.1021\/bi00048a023","article-title":"Analysis of the proteolytic activity of a recombinant form of apolipoprotein(a)","volume":"34","author":"Gabel","year":"1995","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib31","doi-asserted-by":"crossref","first-page":"24004","DOI":"10.1074\/jbc.270.41.24004","article-title":"The recurring evolution of lipoprotein(a). Insights from cloning of hedgehog apolipoprotein(a)","volume":"270","author":"Lawn","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib32","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1016\/S0021-9258(18)83643-2","article-title":"Rhesus monkey apolipoprotein(a). Sequence, evolution, and sites of synthesis","volume":"264","author":"Tomlinson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib33","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1016\/S0021-9258(18)83303-8","article-title":"Apolipoprotein(a) (Apo(a)) glycoprotein isoforms result from size differences in Apo(a) mRNA in baboons","volume":"264","author":"Hixson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0022-2275(20)41215-5","article-title":"Lipoprotein[a] in the chimpanezee: relationship of apo[a] phenotype to elevated plasma Lp[a] levels","volume":"35","author":"Doucet","year":"1994","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib35","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1194\/jlr.M040733","article-title":"Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a)","volume":"54","author":"Leibundgut","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/bi048156p","article-title":"Baboon lipoprotein(a) binds very weakly to lysine-agarose and fibrin despite the presence of a strong lysine-binding site in apolipoprotein(a) kringle IV type 10","volume":"44","author":"Belczewski","year":"2005","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.ATV.11.1.32","article-title":"Lipoprotein(a) in diet-induced atherosclerosis in nonhuman primates","volume":"11","author":"Nachman","year":"1991","journal-title":"Arterioscler. Thromb."},{"key":"10.1194\/jlr.R060582_bib38","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1016\/S0021-9258(19)81051-7","article-title":"Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin","volume":"257","author":"Hoylaerts","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib39","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1021\/bi00417a049","article-title":"Effectors of the activation of human [Glu1]plasminogen by human tissue plasminogen activator","volume":"27","author":"Urano","year":"1988","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/0167-4838(86)90260-8","article-title":"Fibrin and plasminogen structures essential to stimulation of plasmin formation by tissue-type plasminogen activator","volume":"870","author":"Suenson","year":"1986","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.R060582_bib41","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1021\/bi00407a029","article-title":"The course and prerequisites of Lys-plasminogen formation during fibrinolysis","volume":"27","author":"Suenson","year":"1988","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib42","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/272549a0","article-title":"Molecular mechanism of physiological fibrinolysis","volume":"272","author":"Wiman","year":"1978","journal-title":"Nature."},{"key":"10.1194\/jlr.R060582_bib43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1194\/jlr.M036566","article-title":"Inhibition of plasminogen activation by apo(a): role of carboxyl-terminal lysines and identification of inhibitory domains in apo(a)","volume":"55","author":"Romagnuolo","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib44","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/01.ATV.10.2.240","article-title":"Lipoprotein(a), fibrin binding, and plasminogen activation","volume":"10","author":"Loscalzo","year":"1990","journal-title":"Arteriosclerosis."},{"key":"10.1194\/jlr.R060582_bib45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0049-3848(90)90203-O","article-title":"Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator","volume":"57","author":"Edelberg","year":"1990","journal-title":"Thromb. Res."},{"key":"10.1194\/jlr.R060582_bib46","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1021\/bi00015a028","article-title":"Antifibrinolytic effect of recombinant apolipoprotein(a) in vitro is primarily due to attenuation of tPA-mediated Glu-plasminogen activation","volume":"34","author":"Sangrar","year":"1995","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib47","doi-asserted-by":"crossref","first-page":"23260","DOI":"10.1074\/jbc.M302780200","article-title":"Inhibition of plasminogen activation by lipoprotein(a): critical domains in apolipoprotein(a) and mechanism of inhibition on fibrin and degraded fibrin surfaces","volume":"278","author":"Hancock","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib48","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1515\/CCLM.2004.205","article-title":"In vitro inhibition of fibrinolysis by apolipoprotein(a) and lipoprotein(a) is size- and concentration-dependent","volume":"42","author":"Knapp","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1194\/jlr.R060582_bib49","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1111\/j.1538-7836.2008.03183.x","article-title":"Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation","volume":"6","author":"Feric","year":"2008","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib50","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1161\/01.CIR.96.5.1612","article-title":"Apolipoprotein(a) attenuates endogenous fibrinolysis in the rabbit jugular vein thrombosis model in vivo","volume":"96","author":"Biemond","year":"1997","journal-title":"Circulation."},{"key":"10.1194\/jlr.R060582_bib51","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nm0395-256","article-title":"Antifibrinolytic activity of apolipoprotein(a) in vivo: human apolipoprotein(a) transgenic mice are resistant to tissue plasminogen activator-mediated thrombolysis","volume":"1","author":"Palabrica","year":"1995","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.R060582_bib52","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1161\/01.ATV.13.4.548","article-title":"Occlusive arterial thrombosis in cynomolgus monkeys with varying plasma concentrations of lipoprotein(a)","volume":"13","author":"Williams","year":"1993","journal-title":"Arterioscler. Thromb."},{"key":"10.1194\/jlr.R060582_bib53","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1749-6632.2001.tb03514.x","article-title":"Inhibition of fibrinolysis by lipoprotein(a)","volume":"936","author":"Angl\u00e9s-Cano","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1194\/jlr.R060582_bib54","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.ATV.0000021144.87870.C8","article-title":"Lp(a) particles mold fibrin-binding properties of apo(a) in size-dependent manner: a study with different-length recombinant apo(a), native Lp(a), and monoclonal antibody","volume":"22","author":"Kang","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib55","doi-asserted-by":"crossref","first-page":"10353","DOI":"10.1021\/bi962433d","article-title":"The solution phase interaction between apolipoprotein(a) and plasminogen inhibits the binding of plasminogen to a plasmin-modified fibrinogen surface","volume":"36","author":"Sangrar","year":"1997","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib56","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1172\/JCI115855","article-title":"Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations","volume":"90","author":"Boerwinkle","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.R060582_bib57","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1161\/01.CIR.100.11.1154","article-title":"Role of lipoprotein(a) and apolipoprotein(a) phenotype in atherogenesis: prospective results from the Bruneck study","volume":"100","author":"Kronenberg","year":"1999","journal-title":"Circulation."},{"key":"10.1194\/jlr.R060582_bib58","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1001\/jama.2009.801","article-title":"Genetically elevated lipoprotein(a) and increased risk of myocardial infarction","volume":"301","author":"Kamstrup","year":"2009","journal-title":"JAMA."},{"key":"10.1194\/jlr.R060582_bib59","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1194\/jlr.M012526","article-title":"Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study","volume":"52","author":"Lamon-Fava","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib60","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jacc.2014.03.061","article-title":"Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study","volume":"64","author":"Willeit","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.R060582_bib61","doi-asserted-by":"crossref","first-page":"13353","DOI":"10.1021\/bi00041a011","article-title":"Multiple binding with identical linkage: a mechanism that explains the effect of lipoprotein(a) on fibrinolysis","volume":"34","author":"Hervio","year":"1995","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib62","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1365-2362.1996.156288.x","article-title":"The antifibrinolytic effect of lipoprotein(a) in heterozygous subjects is modulated by the relative concentration of each of the apolipoprotein(a) isoforms and their affinity for fibrin","volume":"26","author":"Hervio","year":"1996","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1194\/jlr.R060582_bib63","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1055\/s-0037-1615071","article-title":"Influence of lipoprotein (a) levels and isoforms on fibrinolytic activity\u2013study in families with high lipoprotein (a) levels","volume":"79","author":"Falc\u00f3","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib64","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1161\/01.ATV.17.10.2036","article-title":"Lipoprotein(a) isoforms display differences in affinity for plasminogen-like binding to human mononuclear cells","volume":"17","author":"Kang","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib65","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0022-2275(20)38312-7","article-title":"Binding of apoE-rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist-induced platelet aggregation","volume":"30","author":"Desai","year":"1989","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib66","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1021\/bi00068a021","article-title":"Lipoprotein(a) binds to human platelets and attenuates plasminogen binding and activation","volume":"32","author":"Ezratty","year":"1993","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib67","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/01.ATV.18.9.1393","article-title":"Apolipoprotein(a) enhances platelet responses to the thrombin receptor-activating peptide SFLLRN","volume":"18","author":"Rand","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib68","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1055\/s-0037-1615654","article-title":"Binding of recombinant apolipoprotein(a) to human platelets and effect on platelet aggregation","volume":"85","author":"Mart\u00ednez","year":"2001","journal-title":"Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib69","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/09537109876852","article-title":"Lipoprotein (a) reduces platelet aggregation via apo(a)-mediated decreases in thromboxane A(2)production","volume":"9","author":"Barre","year":"1998","journal-title":"Platelets."},{"key":"10.1194\/jlr.R060582_bib70","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.thromres.2004.01.002","article-title":"Apolipoprotein (a) mediates the lipoprotein (a)-induced biphasic shift in human platelet cyclic AMP","volume":"112","author":"Barre","year":"2003","journal-title":"Thromb. Res."},{"key":"10.1194\/jlr.R060582_bib71","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.thromres.2006.04.013","article-title":"Arginyl-glycyl-aspartyl (RGD) epitope of human apolipoprotein (a) inhibits platelet aggregation by antagonizing the IIb subunit of the fibrinogen (GPIIb\/IIIa) receptor","volume":"119","author":"Barre","year":"2007","journal-title":"Thromb. Res."},{"key":"10.1194\/jlr.R060582_bib72","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cardiores.2004.03.005","article-title":"Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: role of apolipoprotein (a) and endogenous PAF-acetylhydrolase","volume":"63","author":"Tsironis","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1194\/jlr.R060582_bib73","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1182\/blood.V98.10.2980","article-title":"Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis","volume":"98","author":"Caplice","year":"2001","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib74","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood.V71.2.335.335","article-title":"The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action","volume":"71","author":"Broze","year":"1988","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib75","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.clinbiochem.2004.09.011","article-title":"The relationship of TFPI, Lp(a), and oxidized LDL antibody levels in patients with coronary artery disease","volume":"38","author":"Bilgen","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1194\/jlr.R060582_bib76","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1111\/j.1538-7836.2005.01517.x","article-title":"Effects of high plasma lipoprotein (a) levels on tissue factor pathway inhibitor and the protein C pathway","volume":"3","author":"Di Nisio","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib77","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/ejhg.2008.114","article-title":"Genome-wide linkage analysis for identifying quantitative trait loci involved in the regulation of lipoprotein a (Lpa) levels","volume":"16","author":"L\u00f3pez","year":"2008","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1194\/jlr.R060582_bib78","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1538-7836.2005.01365.x","article-title":"Fibrinogen and fibrin structure and functions","volume":"3","author":"Mosesson","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib79","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1182\/blood-2011-03-340422","article-title":"Elevated fibrinogen causes thrombosis","volume":"117","author":"Ari\u00ebns","year":"2011","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib80","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1182\/blood-2010-07-297671","article-title":"Visualization and identification of the structures formed during early stages of fibrin polymerization","volume":"117","author":"Chernysh","year":"2011","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib81","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1161\/ATVBAHA.111.230631","article-title":"Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases","volume":"31","author":"Undas","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib82","doi-asserted-by":"crossref","first-page":"051922","DOI":"10.1103\/PhysRevE.81.051922","article-title":"Toward an understanding of fibrin branching structure","volume":"81","author":"Fogelson","year":"2010","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys."},{"key":"10.1194\/jlr.R060582_bib83","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/ATVBAHA.110.213389","article-title":"Molecular mechanisms affecting fibrin structure and stability","volume":"31","author":"Lord","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib84","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1161\/01.ATV.0000241589.52950.4c","article-title":"Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis","volume":"26","author":"Collet","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib85","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.ATV.20.5.1354","article-title":"Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy","volume":"20","author":"Collet","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib86","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1538-7836.2006.01903.x","article-title":"Lipoprotein(a) as a modifier of fibrin clot permeability and susceptibility to lysis","volume":"4","author":"Undas","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib87","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1111\/j.1538-7836.2007.02637.x","article-title":"Altered fibrin clot structure in patients with advanced coronary artery disease: a role of C-reactive protein, lipoprotein(a) and homocysteine","volume":"5","author":"Undas","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib88","doi-asserted-by":"crossref","first-page":"37154","DOI":"10.1074\/jbc.M305154200","article-title":"Identification and characterization of novel lysine-independent apolipoprotein(a)-binding sites in fibrin(ogen) alphaC-domains","volume":"278","author":"Tsurupa","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib89","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1021\/bi00234a029","article-title":"Apolipoprotein(a): expression and characterization of a recombinant form of the protein in mammalian cells","volume":"30","author":"Koschinsky","year":"1991","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.R060582_bib90","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1182\/blood-2009-11-254029","article-title":"Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin","volume":"115","author":"Mutch","year":"2010","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib91","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1161\/ATVBAHA.107.141291","article-title":"A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease","volume":"27","author":"Luke","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib92","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.atherosclerosis.2008.07.019","article-title":"Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy","volume":"203","author":"Chasman","year":"2009","journal-title":"Atherosclerosis."},{"key":"10.1194\/jlr.R060582_bib93","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.thromres.2014.01.024","article-title":"Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties","volume":"133","author":"Rowland","year":"2014","journal-title":"Thromb. Res."},{"key":"10.1194\/jlr.R060582_bib94","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1111\/j.1538-7836.2005.01540.x","article-title":"Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen","volume":"3","author":"Sha","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib95","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1074\/jbc.M309705200","article-title":"The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells","volume":"279","author":"Pellegrino","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib96","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1161\/01.CIR.102.7.786","article-title":"CC chemokine I-309 is the principal monocyte chemoattractant induced by apolipoprotein(a) in human vascular endothelial cells","volume":"102","author":"Haque","year":"2000","journal-title":"Circulation."},{"key":"10.1194\/jlr.R060582_bib97","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1096\/fasebj.12.15.1765","article-title":"Expression of adhesion molecules by lp(a): a potential novel mechanism for its atherogenicity","volume":"12","author":"Allen","year":"1998","journal-title":"FASEB J."},{"key":"10.1194\/jlr.R060582_bib98","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI116983","article-title":"Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level","volume":"93","author":"Sorensen","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.R060582_bib99","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/0735-1097(95)00321-5","article-title":"Influence of plasma lipoprotein (a) levels on coronary vasomotor response to acetylcholine","volume":"26","author":"Tsurumi","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.R060582_bib100","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0735-1097(97)00237-4","article-title":"Lipoprotein(a) selectively impairs receptor-mediated endothelial vasodilator function of the human coronary circulation","volume":"30","author":"Schachinger","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.R060582_bib101","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/bmm.11.60","article-title":"Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events","volume":"5","author":"Taleb","year":"2011","journal-title":"Biomark. Med."},{"key":"10.1194\/jlr.R060582_bib102","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1194\/jlr.M800174-JLR200","article-title":"A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma","volume":"49","author":"Bergmark","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib103","doi-asserted-by":"crossref","first-page":"52841","DOI":"10.1074\/jbc.M310425200","article-title":"Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a)","volume":"278","author":"Edelstein","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.R060582_bib104","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.bbalip.2010.03.009","article-title":"Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts","volume":"1801","author":"Edelstein","year":"2010","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.R060582_bib105","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.jacc.2011.12.033","article-title":"Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction","volume":"59","author":"Leibundgut","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.R060582_bib106","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1161\/ATVBAHA.108.169292","article-title":"Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area","volume":"28","author":"Klein","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib107","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2261-9-55","article-title":"Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)","volume":"9","author":"Gardener","year":"2009","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1194\/jlr.R060582_bib108","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/01.CIR.88.3.935","article-title":"Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction","volume":"88","author":"Moliterno","year":"1993","journal-title":"Circulation."},{"key":"10.1194\/jlr.R060582_bib109","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1536\/jhj.45.397","article-title":"Relation between serum lipoprotein (a) and residual lesion stenosis of coronary artery after myocardial Infarction without reperfusion therapy","volume":"45","author":"Matsuda","year":"2004","journal-title":"Jpn. Heart J."},{"key":"10.1194\/jlr.R060582_bib110","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/clc.20143","article-title":"Relationship between lipoprotein(a) and spontaneous recanalization of infarct-related arteries in the early phase of acute myocardial infarction","volume":"31","author":"Kim","year":"2008","journal-title":"Clin. Cardiol."},{"key":"10.1194\/jlr.R060582_bib111","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1161\/01.CIR.94.9.2072","article-title":"Serum lipoprotein(a) level is related to thrombin generation and spontaneous intermittent coronary occlusion in patients with acute myocardial infarction","volume":"94","author":"Haider","year":"1996","journal-title":"Circulation."},{"key":"10.1194\/jlr.R060582_bib112","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0140-6736(90)92557-X","article-title":"Lack of association between raised serum Lp(a) concentration and unsuccessful thrombolysis after acute myocardial infarction","volume":"336","author":"Armstrong","year":"1990","journal-title":"Lancet."},{"key":"10.1194\/jlr.R060582_bib113","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/0002-9149(91)90464-V","article-title":"Effects of lipoprotein (a) on success rate of thrombolytic therapy in acute myocardial infarction","volume":"67","author":"von Hodenberg","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"10.1194\/jlr.R060582_bib114","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0002-9149(91)90737-6","article-title":"Coronary recanalization rate after intravenous bolus of alteplase in acute myocardial infarction","volume":"68","author":"Tranchesi","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"10.1194\/jlr.R060582_bib115","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/hrt.71.4.316","article-title":"Serum Lp(a) lipoprotein concentration and outcome of thrombolytic treatment for myocardial infarction","volume":"71","author":"MBewu","year":"1994","journal-title":"Br. Heart J."},{"key":"10.1194\/jlr.R060582_bib116","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0167-5273(94)90265-8","article-title":"Lipoprotein(a) levels in patients with myocardial infarction treated with anistreplase: no prediction of efficacy but inverse correlation with plasminogen activation in non-patency","volume":"45","author":"Br\u00fcgemann","year":"1994","journal-title":"Int. J. Cardiol."},{"key":"10.1194\/jlr.R060582_bib117","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/000331979504600812","article-title":"Does increased lipoprotein (a) impair the effectiveness of thrombolysis with streptokinase?","volume":"46","author":"Tokg\u00f6zo\u011flu","year":"1995","journal-title":"Angiology."},{"key":"10.1194\/jlr.R060582_bib118","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1160\/TH04-02-0097","article-title":"Admission fibrinolytic profile predicts clot lysis resistance in stroke patients treated with tissue plasminogen activator","volume":"91","author":"Ribo","year":"2004","journal-title":"Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib119","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1161\/01.STR.0000137608.73660.4c","article-title":"Admission fibrinolytic profile is associated with symptomatic hemorrhagic transformation in stroke patients treated with tissue plasminogen activator","volume":"35","author":"Ribo","year":"2004","journal-title":"Stroke."},{"key":"10.1194\/jlr.R060582_bib120","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ejim.2007.10.019","article-title":"Venous and arterial thrombosis: different sides of the same coin?","volume":"19","author":"Franchini","year":"2008","journal-title":"Eur. J. Intern. Med."},{"key":"10.1194\/jlr.R060582_bib121","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1182\/blood.V96.10.3364","article-title":"Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism","volume":"96","author":"von Depka","year":"2000","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib122","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.amjmed.2007.01.029","article-title":"Lipoprotein (a) and venous thromboembolism in adults: a meta-analysis","volume":"120","author":"Sofi","year":"2007","journal-title":"Am. J. Med."},{"key":"10.1194\/jlr.R060582_bib123","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1055\/s-0032-1301420","article-title":"The thrombophilic pattern of different clinical manifestations of venous thromboembolism: a survey of 443 cases of venous thromboembolism","volume":"38","author":"Grifoni","year":"2012","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1194\/jlr.R060582_bib124","first-page":"726","article-title":"Lipoprotein(a) concentration is not associated with venous thromboembolism in a case control study","volume":"84","author":"Lippi","year":"1999","journal-title":"Haematologica."},{"key":"10.1194\/jlr.R060582_bib125","first-page":"1068","article-title":"Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism","volume":"87","author":"Libourel","year":"2002","journal-title":"Haematologica."},{"key":"10.1194\/jlr.R060582_bib126","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/archinte.162.10.1182","article-title":"Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology","volume":"162","author":"Tsai","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"10.1194\/jlr.R060582_bib127","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.thromres.2010.06.007","article-title":"Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE","volume":"126","author":"Rodger","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1194\/jlr.R060582_bib128","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1160\/TH12-06-0426","article-title":"Lipid levels do not influence the risk of venous thromboembolism. Results of a population-based cohort study","volume":"108","author":"van Schouwenburg","year":"2012","journal-title":"Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib129","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/ATVBAHA.112.248765","article-title":"Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis","volume":"32","author":"Kamstrup","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib130","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jacc.2012.01.078","article-title":"Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism","volume":"60","author":"Helgadottir","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.R060582_bib131","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jth.12056","article-title":"Lipoprotein(a), polymorphisms in the LPA gene, and incident venous thromboembolism among 21483 women","volume":"11","author":"Danik","year":"2013","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib132","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2796.2012.02592.x","article-title":"Lipoprotein(a): resurrected by genetics","volume":"273","author":"Kronenberg","year":"2013","journal-title":"J. Intern. Med."},{"key":"10.1194\/jlr.R060582_bib133","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/01.CIR.100.7.743","article-title":"Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood","volume":"100","author":"Nowak-G\u00f6ttl","year":"1999","journal-title":"Circulation."},{"key":"10.1194\/jlr.R060582_bib134","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1182\/blood.V94.11.3678","article-title":"Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood","volume":"94","author":"Nowak-G\u00f6ttl","year":"1999","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib135","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/S0140-6736(02)11520-0","article-title":"Prospective assessment of risk factors for recurrent stroke during childhood\u2013a 5-year follow-up study","volume":"360","author":"Str\u00e4ter","year":"2002","journal-title":"Lancet."},{"key":"10.1194\/jlr.R060582_bib136","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1182\/blood.V97.4.858","article-title":"Childhood Thrombophilia Study Group. Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors","volume":"97","author":"Nowak-G\u00f6ttl","year":"2001","journal-title":"Blood."},{"key":"10.1194\/jlr.R060582_bib137","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3324\/haematol.2012.073833","article-title":"Elevated lipoprotein (a), small apolipoprotein (a), and the risk of arterial ischemic stroke in North American children","volume":"98","author":"Goldenberg","year":"2013","journal-title":"Haematologica."},{"key":"10.1194\/jlr.R060582_bib138","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.thromres.2010.11.002","article-title":"Lipoprotein(a) and the risk of thromboembolism in Thai children","volume":"127","author":"Sirachainan","year":"2011","journal-title":"Thromb. Res."},{"key":"10.1194\/jlr.R060582_bib139","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/MOL.0b013e32835111d8","article-title":"Lipoprotein(a): more interesting than ever after 50 years","volume":"23","author":"Dub\u00e9","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1194\/jlr.R060582_bib140","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1194\/jlr.M400467-JLR200","article-title":"High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins","volume":"46","author":"Schneider","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib141","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1194\/jlr.M006742","article-title":"Lipoprotein(a) accelerates atherosclerosis in uremic mice","volume":"51","author":"Pedersen","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R060582_bib142","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1538-7836.2008.03186.x","article-title":"Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model","volume":"7","author":"Kuijpers","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1194\/jlr.R060582_bib143","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/ATVBAHA.114.303315","article-title":"Factor XII regulates the pathological process of thrombus formation on ruptured plaques","volume":"34","author":"Kuijpers","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib144","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/ATVBAHA.114.303209","article-title":"Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques","volume":"34","author":"van Montfoort","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.R060582_bib145","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/ATVBAHA.112.251306","article-title":"Mechanisms of lipoprotein(a) pathogenicity: prothrombotic, proatherosclerotic, or both?","volume":"32","author":"Spence","year":"2012","journal-title":"Arterio\u00adscler. Thromb. Vasc. Biol."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520309792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520309792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.R060582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T15:32:14Z","timestamp":1637422334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520309792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":145,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0022227520309792"],"URL":"https:\/\/doi.org\/10.1194\/jlr.r060582","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease?","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.R060582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}