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Genet."},{"key":"10.1194\/jlr.R075481_bib4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science."},{"key":"10.1194\/jlr.R075481_bib5","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. 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Lett."},{"key":"10.1194\/jlr.R075481_bib97","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1212\/WNL.50.4.961","article-title":"Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy","volume":"50","author":"Greenberg","year":"1998","journal-title":"Neurology."},{"key":"10.1194\/jlr.R075481_bib98","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/NEN.0b013e31829a25b9","article-title":"APOE-epsilon2 and APOE-epsilon4 correlate with increased amyloid accumulation in cerebral vasculature","volume":"72","author":"Nelson","year":"2013","journal-title":"J. Neuropathol. Exp. 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Lipid Res."},{"key":"10.1194\/jlr.R075481_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-2275(20)33334-4","article-title":"Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E","volume":"40","author":"Mahley","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.R075481_bib110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/mcne.1999.0816","article-title":"Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain","volume":"15","author":"Cotman","year":"2000","journal-title":"Mol. Cell. 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Blood Flow Metab."},{"key":"10.1194\/jlr.R075481_bib128","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuron.2015.09.036","article-title":"Lack of widespread BBB disruption in Alzheimer's disease models: focus on therapeutic antibodies","volume":"88","author":"Bien-Ly","year":"2015","journal-title":"Neuron."},{"key":"10.1194\/jlr.R075481_bib129","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nm1058","article-title":"Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides","volume":"10","author":"Koistinaho","year":"2004","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.R075481_bib130","doi-asserted-by":"crossref","first-page":"35722","DOI":"10.1074\/jbc.M701823200","article-title":"Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E","volume":"282","author":"Saavedra","year":"2007","journal-title":"J. Biol. 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