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Aging."},{"key":"10.1194\/jlr.R075796_bib65","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/JAD-2010-101248","article-title":"Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-beta is an early biomarker for mild cognitive impairment preceding Alzheimer's disease","volume":"24","author":"Sagare","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1194\/jlr.R075796_bib66","doi-asserted-by":"crossref","first-page":"8850","DOI":"10.1073\/pnas.151261398","article-title":"Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease","volume":"98","author":"DeMattos","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.R075796_bib67","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0092-8674(95)90320-8","article-title":"LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation","volume":"82","author":"Kounnas","year":"1995","journal-title":"Cell."},{"key":"10.1194\/jlr.R075796_bib68","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0006-8993(96)00711-1","article-title":"Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)","volume":"740","author":"Knauer","year":"1996","journal-title":"Brain Res."},{"key":"10.1194\/jlr.R075796_bib69","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1074\/jbc.275.10.7410","article-title":"Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). 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Chem."},{"key":"10.1194\/jlr.R075796_bib72","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1046\/j.1471-4159.1997.69051904.x","article-title":"Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein","volume":"69","author":"Narita","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.R075796_bib73","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1046\/j.1471-4159.1999.0731393.x","article-title":"Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons","volume":"73","author":"Qiu","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.R075796_bib74","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1194\/jlr.R075796_bib75","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.1523\/JNEUROSCI.3487-13.2013","article-title":"Neuronal clearance of amyloid-beta by endocytic receptor LRP1","volume":"33","author":"Kanekiyo","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1194\/jlr.R075796_bib76","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1523\/JNEUROSCI.3442-16.2017","article-title":"Astrocytic LRP1 mediates brain A\u03b2 clearance and impacts amyloid deposition","volume":"37","author":"Liu","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1194\/jlr.R075796_bib77","first-page":"157","article-title":"Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathy","volume":"77","author":"Urmoneit","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1194\/jlr.R075796_bib78","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer's amyloid-\u03b21-40 peptide from brain by LDL receptor\u2013related protein-1 at the blood-brain barrier","volume":"106","author":"Shibata","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.R075796_bib79","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1471-4159.2010.06708.x","article-title":"Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-beta peptide(1-40) in mouse: involvement of an LRP-1-independent pathway","volume":"113","author":"Ito","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.R075796_bib80","doi-asserted-by":"crossref","first-page":"2323.e1","DOI":"10.1016\/j.neurobiolaging.2010.05.025","article-title":"LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier","volume":"32","author":"Pflanzner","year":"2011","journal-title":"Neurobiol. Aging."},{"key":"10.1194\/jlr.R075796_bib81","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nbd.2007.12.005","article-title":"LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model","volume":"30","author":"Nazer","year":"2008","journal-title":"Neurobiol. 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Alzheimers Dis."},{"key":"10.1194\/jlr.R075796_bib84","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1172\/JCI81108","article-title":"Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrier","volume":"126","author":"Storck","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.R075796_bib85","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nm1287","article-title":"Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease","volume":"11","author":"Wu","year":"2005","journal-title":"Nat. Med."},{"key":"10.1194\/jlr.R075796_bib86","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neurobiolaging.2016.02.025","article-title":"Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease","volume":"42","author":"Soto","year":"2016","journal-title":"Neurobiol. 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Sci."},{"key":"10.1194\/jlr.R075796_bib107","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.2353\/ajpath.2007.070050","article-title":"Lipoprotein receptor-related protein-1 mediates amyloid-\u03b2-mediated cell death of cerebrovascular cells","volume":"171","author":"Wilhelmus","year":"2007","journal-title":"Am. J. 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Chem."},{"key":"10.1194\/jlr.R075796_bib147","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(01)03367-4","article-title":"Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein","volume":"928","author":"Nathan","year":"2002","journal-title":"Brain Res."},{"key":"10.1194\/jlr.R075796_bib148","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.294.5545.1354","article-title":"CNS synaptogenesis promoted by glia-derived cholesterol","volume":"294","author":"Mauch","year":"2001","journal-title":"Science."},{"key":"10.1194\/jlr.R075796_bib149","doi-asserted-by":"crossref","first-page":"14009","DOI":"10.1074\/jbc.M313828200","article-title":"Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures","volume":"279","author":"Hayashi","year":"2004","journal-title":"J. Biol. 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