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Immunol."},{"key":"10.1194\/jlr.R120001116_bib69","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1046\/j.1365-2567.1999.00845.x","article-title":"Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites","volume":"97","author":"Schuurman","year":"1999","journal-title":"Immunology."},{"key":"10.1194\/jlr.R120001116_bib70","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.0019-2805.2001.01341.x","article-title":"IgG4 breaking the rules","volume":"105","author":"Aalberse","year":"2002","journal-title":"Immunology."},{"key":"10.1194\/jlr.R120001116_bib71","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/CIRCGENETICS.111.960864","article-title":"Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia","volume":"5","author":"Johansen","year":"2012","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1194\/jlr.R120001116_bib72","doi-asserted-by":"crossref","first-page":"626","DOI":"10.7326\/M19-0203","article-title":"The chylomicronemia syndrome is most often multifactorial: a narrative review of causes and treatment","volume":"170","author":"Chait","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1194\/jlr.R120001116_bib73","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fendo.2020.00455","article-title":"Genetics of Hypertriglyceridemia","volume":"11","author":"Dron","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1194\/jlr.R120001116_bib74","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jacl.2018.10.004","article-title":"GPIHBP1 autoantibody syndrome during interferon beta1a treatment","volume":"13","author":"Eguchi","year":"2019","journal-title":"J. Clin. Lipidol."},{"key":"10.1194\/jlr.R120001116_bib75","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jacl.2020.01.012","article-title":"Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies","volume":"14","author":"Ashraf","year":"2020","journal-title":"J. Clin. Lipidol."},{"key":"10.1194\/jlr.R120001116_bib76","doi-asserted-by":"crossref","unstructured":"Lutz, J., M., Dunaj-Kazmierowska, S., Arcan, U., Kassner, K., Miyashita, M., Murakami, M., Ploug, L. G., Fong, S. G., Young, K., Nakajima, . Chylomicronemia from GPIHBP1 autoantibodies successfully treated with rituximab: a case report. Ann. Intern. Med. Epub ahead of print. 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Acta."},{"key":"10.1194\/jlr.R120001116_bib84","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ajh.25301","article-title":"Systematic literature review of treatments used for adult immune thrombocytopenia in the second-line setting","volume":"94","author":"Bylsma","year":"2019","journal-title":"Am. J. Hematol."},{"key":"10.1194\/jlr.R120001116_bib85","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1111\/trf.14841","article-title":"Systematic review of rituximab for autoimmune diseases: a potential alternative to intravenous immune globulin","volume":"58","author":"MacIsaac","year":"2018","journal-title":"Transfusion."},{"key":"10.1194\/jlr.R120001116_bib86","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(19)31778-7","article-title":"Pemphigus","volume":"394","author":"Schmidt","year":"2019","journal-title":"Lancet."},{"key":"10.1194\/jlr.R120001116_bib87","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1056\/NEJM198905113201906","article-title":"Autoimmune hyperchylomicronemia","volume":"320","author":"Kihara","year":"1989","journal-title":"N. Engl. J. 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Thromb."},{"key":"10.1194\/jlr.R120001116_bib94","first-page":"791","article-title":"Characterization of a new case of autoimmune type I hyperlipidemia: long-term remission under immunosuppressive therapy","volume":"82","author":"Pruneta","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.R120001116_bib95","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1210\/jc.2005-0205","article-title":"Combination of circulating antilipoprotein lipase (Anti-LPL) antibody and heterozygous S172 fsX179 mutation of LPL gene leading to chronic hyperchylomicronemia","volume":"90","author":"Pruneta-Deloche","year":"2005","journal-title":"J. Clin. Endocrinol. 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